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2012 Vol. 30, No. 5

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Application of microbial transformation in natural products research
LIU Qing-xin, LI Hui-liang, LIU Run-hui
2012, 30(5): 321-325. doi: 10.3969/j.issn.1006-0111.2012.05.001
Abstract(5933) PDF (849KB)(998)
Abstract:
With the continuous development of biotechnology technology, microbial transformation gradually was applied to the study of natural products. The specific effective reactions, mild reaction conditions and high yield of the microbial transformation we...
Progress in pulsatile drug delivery system
LI Ying, LU Yang, DU Shou-ying, MA Yong, XU Pan
2012, 30(5): 326-330,343. doi: 10.3969/j.issn.1006-0111.2012.05.002
Abstract(5636) PDF (360KB)(1255)
Abstract:
Pulsatile drug delivery system developed quickly with the further study of chronobiology and chronopharmacology, which controled drug release and dosage by the method of formulation, and could coordinate the change of physiological rhythm, furthermor...
Preparation and application of solid lipid nano-particles
XIA Ai-xiao, SONG Qian-qian, SUN yuan
2012, 30(5): 331-333,368. doi: 10.3969/j.issn.1006-0111.2012.05.003
Abstract(5314) PDF (279KB)(948)
Abstract:
Objective To review the latest research progress of the solid lipid nano-particle. Methods Domestic and foreign representative literature information of solid lipid nano-particles and its application were analyzed and summarized. Results Many ki...
Antimicrobial activities of naphthoquinone derivatives extracted from plants
MIAO Hao, CAO Ying-ying, SHANG Qing-hua, JIANG Yuan-ying
2012, 30(5): 334-335,360. doi: 10.3969/j.issn.1006-0111.2012.05.004
Abstract(5218) PDF (224KB)(1491)
Abstract:
Naphthoquinones were widely distributed in some traditional medicine plants. Shikonin, juglone, lawsone, plumbagin were naturally occurring naphthoquinones of the traditional medicine plant. The research results indicated that naphthoquinones and nap...
Progress on pharmacokinetics of lopinavir
YAO Ya-min, MU Jun, SUN Ji, MA Fang, LU Hong-zhou, ZHANG Li-jun
2012, 30(5): 336-339. doi: 10.3969/j.issn.1006-0111.2012.05.005
Abstract(4587) PDF (318KB)(1416)
Abstract:
Lopinavir was widely used as a second generation protease inhibitor in AIDS therapy, which was quickly metabolized by CYP3A4. For individual variance might lead to different metabolism, it was important to study the pharmacokinetic parameters of lopi...
Application of fingerprint-efficacy in studies of extraction and purification method of traditional Chinese medicine
LI Xue-jing, FAN Cheng-long, SONG Hong-tao
2012, 30(5): 340-343. doi: 10.3969/j.issn.1006-0111.2012.05.006
Abstract(5241) PDF (265KB)(1250)
Abstract:
To build a effective method to evaluate the safety and efficacy of TMC was a main problem in TMC quality control system.The TMC quality affected the clinical curative effect directely, which was the bottle neck of the TMC modernization according to t...
Synthesis,crystal structures and antifungal activity of novel triazole compounds containing 1,3-dioxolane
REN Xiao-hui, CHEN Xin, LIU Jia, ZHENG Can-hui, REN Xue-qin, WU Bing, WANG Ru-feng, ZHOU You-jun
2012, 30(5): 344-347. doi: 10.3969/j.issn.1006-0111.2012.05.007
Abstract(5527) PDF (445KB)(350)
Abstract:
Objective To synthesize the geometric isomer of (E)-1-((4-(2,4-difluorophenyl)-2-(4-fluorostyryl)-1,3-dioxolan-4-yl)methyl)-1H-1,2,4-triazole, determine their structures by XRD and evaluate their antifungal activities in vitro. Methods The target c...
Optimization of the matrix formulation of Huoxuetongluo cataplasmata by orthogonal design
ZENG Chao
2012, 30(5): 348-350. doi: 10.3969/j.issn.1006-0111.2012.05.008
Abstract(4657) PDF (201KB)(681)
Abstract:
Objective To optimize the matrix formulation of Huoxuetongluo cataplasmata. Methods The optimal preparation was selected by L16 (45) orthogonal design. The adhering potential, fissility, ability to spread out, homogeneity, ability pasting to skin a...
Study on HPLC fingerprint of Semen Sojae Preparatum(SSP)
LIAO Li-na, ZHANG Ming-min, CAO Wei-wei, MAO Jun-qin
2012, 30(5): 351-352,386. doi: 10.3969/j.issn.1006-0111.2012.05.009
Abstract(4385) PDF (382KB)(456)
Abstract:
To establish a HPLC fingerprint method for Semen Sojae Preparatumto quality control. Methods HPLC analysis was performed on a Diamonsil C18 column (250 mm×4.6 mm,5 μm),the mobile phase was used in gradient elution consisted of methanol-water(3% ace...
Analysis of the essential oil from the compound preparation of Fuzhengpingxiao capsule by GC-MS
LV Leia, LI Lingb, TIAN Wen-juna, ZHANG Haia, LI Yue-yuea, ZHANG Guo-qinga, ZHAO Liang
2012, 30(5): 353-356. doi: 10.3969/j.issn.1006-0111.2012.05.010
Abstract(4227) PDF (320KB)(361)
Abstract:
Objective To analyze the chemical components of the essential oil from Fuzhengpingxiao capsule by GC-MS. Methods The essential oil was extracted by steam distillation,the chemical components of the essential oil were detected by GC-MS.Peaks and the...
The effect of Fructus Mume water extract on experimental ulcerative colitis in mice
HE Ai-ming, WANG Yi-hui, LIN Shi-ming
2012, 30(5): 357-360. doi: 10.3969/j.issn.1006-0111.2012.05.011
Abstract(4411) PDF (280KB)(236)
Abstract:
Objective To study the effect of Fructus Mume(FM) on superoxide dismutase(SOD) activity and malondialdehyde(MDA) content in ulcerative colitis in mouse. Methods The mouse model of ulcerative colitis was set up by giving 3% dextran sulfate sodium(D...
Analysis of incidence and influencing factors of systemic inflammatory response syndrome after hepatectomy
GONG Chun-guia, WANG Binb, ZHAN Qib, JIN Rou-nanb, JIANG Yun-xiab, YAN Jian-jun
2012, 30(5): 361-364. doi: 10.3969/j.issn.1006-0111.2012.05.012
Abstract(4198) PDF (263KB)(207)
Abstract:
Objective To analyze the lever and dynamics of systemic inflammatory response syndrome in the patients after hepatectomy, so as to provide some references for the treatment of preventing SIRS and decrease of infection rate. Methods The occurrence ...
The stability of compatibility of carbazochrome sodium sulfonate with four transfusions in common use
ZHANG Hai-hong, LIU Fang
2012, 30(5): 365-368. doi: 10.3969/j.issn.1006-0111.2012.05.013
Abstract(4945) PDF (401KB)(1101)
Abstract:
Objective To study the stability of compatibility of carbazochrome sodium sulfonate with four different transfusions for 6 hours at room temperature. Methods The content and related substances of carbazochrome sodium for sulfonate injection in four...
Preparation and in vitro release of Garcinia glycosides sustained-release tablets
CHEN Ye, WANG Yang, LIU Zhong-chen, LI Wen-jun, DENG Jing-jing, XU Li-feng
2012, 30(5): 369-371,375. doi: 10.3969/j.issn.1006-0111.2012.05.014
Abstract(5081) PDF (571KB)(296)
Abstract:
Objective To prepare Garcinia glycosides sustained-release tables and study their in vitro release characteristics. Methods Garcinia glycosides sustained-release tablets were prepared by hydroxypropylmethyl cellulose (HPMC) as gel matrix material ...
Pharmacokinetics and relative bioavailability of Sparfloxacin in healthy volunteer
SUI Miao, WANG Xiao-bo, XI Rong-gang, SUN Jia-dan
2012, 30(5): 372-375. doi: 10.3969/j.issn.1006-0111.2012.05.015
Abstract(4034) PDF (405KB)(338)
Abstract:
Objective To determine Sparfloxacin concentrations in human plasma and study the pharmacokinetics and relative bioavailability of Sparfloxacin for Suspension. Methods A single dose reference and test was given to 20 healthy volunteers in a randomi...
Determination of tetrahydropalmatine in Lianlian capsule by HPLC
SONG Lei, JI Feng
2012, 30(5): 376-377,383. doi: 10.3969/j.issn.1006-0111.2012.05.016
Abstract(4012) PDF (290KB)(226)
Abstract:
Objective To establish a HPLC method for tetrahydropalmatine in Lianlian capsule. Method The determination method of Lianlian capsule was carried out by HPLC, which quantitative index was represented with tetrahydropalmatine. Result The calibration ...
Determination of two flavones in Polygonum hydropiper Linn
ZHANG Hong-wu, REN Heng-chun, DING Gang, LI Rong-tao, WEI Jian-he, ZOU Zhong-mei
2012, 30(5): 378-379,389. doi: 10.3969/j.issn.1006-0111.2012.05.017
Abstract(4017) PDF (285KB)(260)
Abstract:
To established the HPLC method for simultaneously determination of quercitin and quercitrin in Polygonum hydropiper Linn. Methods A VertiSep GES C18 (250 mm ×4.6 mm,5.0 μm)column was adopted with a mobile phase of acetonitrile-0.1% formic acid wate...
Brief analysis the application of several signal monitoring methods in adverse drug events
DAI Fei, SHU Li-xin, CHU Cang, CHENG Sheng-xin, CHU Wen-gong
2012, 30(5): 380-383. doi: 10.3969/j.issn.1006-0111.2012.05.018
Abstract(4893) PDF (290KB)(1494)
Abstract:
Objective To analyze several adverse drug reaction monitoring methods in home and aboard. Methods Literature analysis and system analysis method were used to illustrate a series of calculation methods in signal extraction of adverse drug reaction. ...
Evaluation and analysis of irrational prescription from 965 outpatients
JIN Jin
2012, 30(5): 384-386. doi: 10.3969/j.issn.1006-0111.2012.05.019
Abstract(4529) PDF (300KB)(314)
Abstract:
Objective To grasp current status of irrational prescriptions in outpatient department of our hospital and to promote clinically rational use of drugs. Method Based on the irrational prescription criteria taken from management of prescriptions and s...
Analysis and countermeasures on the quality issues of the sampling inspection preparation of the Jinan Military Region in 2007~2011
ZHAO Qing-hua, GONG Wei, WANG Ai-wu, ZHANG Zhen-xin
2012, 30(5): 387-389. doi: 10.3969/j.issn.1006-0111.2012.05.020
Abstract(3682) PDF (222KB)(388)
Abstract:
Objective To analyse the quality issues of preparation in Jinan Military Region and improve the quality of preparation in medical institutions. Methods According to the 2007~2011 inspection records and the test results, the main quality problems o...
The practice of spectrum analysis experiment teaching based on comprehensive structure identification
HONG Zhan-yinga, WEN Juna, ZHAO Jing-xiab, ZHAO Wei-quana, LI Lingb, CHAI Yi-fenga, FAN Guo-rong
2012, 30(5): 390-391,398. doi: 10.3969/j.issn.1006-0111.2012.05.021
Abstract(3926) PDF (204KB)(471)
Abstract:
The practice of spectrum analysis experiment teaching based on comprehensive structure identification was to simulate the procedure of elucidating structure by spectroscopy methods, including UV, IR, NMR and MS in new drug research, which could help ...
Exploration and practice of comprehensive and designing experiment of pharmacy based on inter-discipline
JIANG Qing-lin, ZHENG Xiang-hui, WANG Di-juan, ZANG Zhi-he
2012, 30(5): 392-393,400. doi: 10.3969/j.issn.1006-0111.2012.05.022
Abstract(4167) PDF (202KB)(472)
Abstract:
Pharmacy was a comprehensive and inter-disciplinary course. The comprehensive and designing experiment of pharmacy based on inter-discipline was set up in the pharmacy experiments relying on experimental teaching center, which not only improve the st...
The multi-disciplinary experiments of pharmacy:preparation of aspirin tablets
WU Wen-bin, CAI Guo-jun, HONG Wei, YAN Zhong-jun, LU Ying
2012, 30(5): 394-398. doi: 10.3969/j.issn.1006-0111.2012.05.023
Abstract(4911) PDF (310KB)(272)
Abstract:
Objective During internship of pharmacy student, multidisciplinary pharmacy experiment about preparation of Aspirin tablet was performed. Methods Three in group of the pharmacy students completed literature review and experimental design. the aspi...
Organization of pharmacy administration teaching for pre-selected medical noncommissioned officers from the point of practical ability improvement
CHU Cang, FAN Li, LUAN Zhi peng, SHU Li xin, ZHANG Hong wu
2012, 30(5): 399-400. doi: 10.3969/j.issn.1006-0111.2012.05.024
Abstract(4519) PDF (164KB)(196)
Abstract:
The pharmacy administration teaching for the pre-selected medical noncommissioned officers was a new task and there was no experience to follow. Based on the author's own practical experience, systematic conclusion from the curriculum designation, th...