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ZHAO Anpeng, JIN Ting, WANG Rong. Protective effect of areca catechu linn ethanol extract against hypoxia in H9C2 cells[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 294-298. doi: 10.3969/j.issn.1006-0111.2019.04.002
Citation: SUI Miao, WANG Xiao-bo, XI Rong-gang, SUN Jia-dan. Pharmacokinetics and relative bioavailability of Sparfloxacin in healthy volunteer[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(5): 372-375. doi: 10.3969/j.issn.1006-0111.2012.05.015

Pharmacokinetics and relative bioavailability of Sparfloxacin in healthy volunteer

doi: 10.3969/j.issn.1006-0111.2012.05.015
  • Received Date: 2012-02-27
  • Rev Recd Date: 2012-05-02
  • Objective To determine Sparfloxacin concentrations in human plasma and study the pharmacokinetics and relative bioavailability of Sparfloxacin for Suspension. Methods A single dose reference and test was given to 20 healthy volunteers in a randomized 2-way cross-over study. The plasma Sparfloxacin concentrations were determined by HPLC. The pharmacokinetics as well as relative bioavailability was measured. Results The main pharmacokinetic parameters of two formulations, Sparfloxacin in test and reference drug were as follows:tmax were (4.68±0.44)and(4.55±0.51)h;Cmax were(1 560.4±243.9)and(1 584.1±273.9)ng/ml;t1/2 were(20.92±4.85)and (19.81±3.75)h;AUC0-t were (43 325±12 174)and(44 139±11 815)ng·h/ml;AUC0-∞ were(45 452±12 884)and(45 999±12 629)ng·h/ml respectively. Using DASS program, the results of variance and two one-sided t-test statistical analyses for Ln Cmax. Two formulations were bioequivalent. Conclusion The reference and test Sparfloxacin were bioequivalent.
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Pharmacokinetics and relative bioavailability of Sparfloxacin in healthy volunteer

doi: 10.3969/j.issn.1006-0111.2012.05.015

Abstract: Objective To determine Sparfloxacin concentrations in human plasma and study the pharmacokinetics and relative bioavailability of Sparfloxacin for Suspension. Methods A single dose reference and test was given to 20 healthy volunteers in a randomized 2-way cross-over study. The plasma Sparfloxacin concentrations were determined by HPLC. The pharmacokinetics as well as relative bioavailability was measured. Results The main pharmacokinetic parameters of two formulations, Sparfloxacin in test and reference drug were as follows:tmax were (4.68±0.44)and(4.55±0.51)h;Cmax were(1 560.4±243.9)and(1 584.1±273.9)ng/ml;t1/2 were(20.92±4.85)and (19.81±3.75)h;AUC0-t were (43 325±12 174)and(44 139±11 815)ng·h/ml;AUC0-∞ were(45 452±12 884)and(45 999±12 629)ng·h/ml respectively. Using DASS program, the results of variance and two one-sided t-test statistical analyses for Ln Cmax. Two formulations were bioequivalent. Conclusion The reference and test Sparfloxacin were bioequivalent.

ZHAO Anpeng, JIN Ting, WANG Rong. Protective effect of areca catechu linn ethanol extract against hypoxia in H9C2 cells[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 294-298. doi: 10.3969/j.issn.1006-0111.2019.04.002
Citation: SUI Miao, WANG Xiao-bo, XI Rong-gang, SUN Jia-dan. Pharmacokinetics and relative bioavailability of Sparfloxacin in healthy volunteer[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(5): 372-375. doi: 10.3969/j.issn.1006-0111.2012.05.015
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