Progress on the mechanisms of protective effects on endothelial progenitor cells from natural medicines and their active compounds

DONG Ya-fen; SHU Jing-jing; MA Jing; LI Fei; PENG Cheng; JIN Lei; XIE He-hui; ZHANG Chuan

doi:10.3969/j.issn.1006-0111.2013.01.003

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Volume 31 Issue 1

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2013 > 31(1): 11-13,31

DONG Ya-fen, SHU Jing-jing, MA Jing, LI Fei, PENG Cheng, JIN Lei, XIE He-hui, ZHANG Chuan. Progress on the mechanisms of protective effects on endothelial progenitor cells from natural medicines and their active compounds[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 11-13,31. doi: 10.3969/j.issn.1006-0111.2013.01.003

Citation:

DONG Ya-fen, SHU Jing-jing, MA Jing, LI Fei, PENG Cheng, JIN Lei, XIE He-hui, ZHANG Chuan. Progress on the mechanisms of protective effects on endothelial progenitor cells from natural medicines and their active compounds[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 11-13,31. doi: 10.3969/j.issn.1006-0111.2013.01.003

Progress on the mechanisms of protective effects on endothelial progenitor cells from natural medicines and their active compounds

doi: 10.3969/j.issn.1006-0111.2013.01.003

1.
Fujian University of Traditional Chinese Medicine, Fuzhou 350100, China
2.
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2012-02-13
Rev Recd Date: 2012-05-27

Abstract

The integrity and function of the endothelium played a key role in the prevention of cardiovascular diseases (CVDs). The maintenance of normal endothelial function not only depended on pre-existing endothelial cells, but also included the recruitment of endothelial progenitor cells (EPC), and EPC might serve as a therapeutic target of CVDs. Application of natural medicines and their active compounds in the treatment of CVDs, and their effects on EPC had been reported previously. The mechanisms underlying the protection of natural medicines and their active compounds on endothelial progenitor cells were summarized in this paper.
- natural medicine,
- endothelial progenitor cell,
- oxidative stress,
- inflammation

References

[1]	Asahara T, Murohara T, Sullivan A, et a1. Isolation of putative progenitor endothelial cells for angiogenesis[J].Science, 1997, 275(5302): 964.
[2]	Lu L, Zhou JZ, Wang L,et al. Effects of Xuezhikang and pravastatin on circulating endothelial progenitor cells in patients with essential hypertension[J].Chin J Integr Med. 2009, 15(4): 266.
[3]	Gao D, Wu LY, Jiao YH, et al. The effect of Xuefu Zhuyu Decoction on in vitro endothelial progenitor cell tube formation[J].Chin J Integr Med, 2010, 16(1): 50.
[4]	Gao D, Wu LY, Jiao YH, et al. Effects of Xuefu Zhuyu decoction on EPCs function[J].Zhong Yao Cai,2010, 33(7): 1129.
[5]	吴建祥, 梁春, 任雨笙, 等. 麝香保心丸对内皮祖细胞功能及分泌一氧化氮的影响[J].中国中草药结合杂志,2009, 29(6): 511.
[6]	Shi AW, Wang XB, Lu FX. Ginsenoside Rg1 promotes endothelial progenitor cell migration and proliferation[J].Acta Pharmacol Sin,2009, 30(3): 299.
[7]	季亢挺, 张怀勤, 唐疾飞, 等. 丹参对高胆固醇血症患者内皮祖细胞数量及功能的影响[J].中国中药杂志,2007, 32(12): 1214.
[8]	Chan YH, Lam TH, Lau KK, et al. Dietary intake of phytoestrogen is associated with increased circulating endothelial progenitor cells in patients with cardiovascular disease[J].Eur J Cardiovasc Prev Rehabil,2011, 18(3): 360.
[9]	王胜男, 叶攀, 敖杰男. 丹参素对过氧化氢所致人脐静脉内皮细胞损伤的保护作用研究[J].时珍国医国药, 2011, 22(1): 66.
[10]	Zhao GR, Zhang HM, Ye TX, et al. Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B[J].Food and Chemical Toxicology,2008, 46(1): 73.
[11]	吴丽元, 党西强, 何小解, 等. 儿茶素清除超氧阴离子对AngⅡ诱导的内皮祖细胞NO与eNOS表达及凋亡影响[J].中国当代儿科杂志, 2009, 11(6): 476.
[12]	朱军慧, 王兴祥, 陈君柱, 等. 高胆固醇对内皮祖细胞数量和功能的影响[J].中华内科杂志, 2004, 43(4): 261.
[13]	Vasa M, Fichtlscherer S, Aicher A, et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease[J].Circ Res, 2001, 89(1): E1.
[14]	Hamed S, Brenner B, Abassi Z, et al. Hyperglycemia and Oxidized-LDL exert a deleterious effect on Endothelial Progenitor Cell migration in Type 2 Diabetes Mellitus[J].Thrombosis Research, 2010, 126(3): 166.
[15]	Ji KT, Chai JD, Cheng X, et al. Danshen protects endothelial progenitor cells from oxidized low-density lipoprotein induced impairment[J]. Zhejiang Univ-SciB (Biomed & Biotechnol), 2010 , 11(8): 618.
[16]	Ridker PM, Glynn RJ, Henneken CH. C-reactive protein adds to the predictive value of total and HDL cholesterol In determining risk of first myocardial infarction[J].Circulation, 1998, 97(20): 2007.
[17]	崔斌, 黄岚, 宋耀明, 等.冠心病患者高敏C反应蛋白与循环内皮祖细胞的关系及临床意义[J].重庆医学, 2005, 34(9): 1344.
[18]	崔斌, 黄岚, 谭虎. C反应蛋白对内皮祖细胞部分生物学功能的影响及其机制的实验研究[J].中华心血管病杂志, 2008, 36(5): 435.
[19]	南景龙, 李建军. C反应蛋白通过CD32影响人内祖细胞分泌白细胞介素8[J].中华老年心脑血管病杂志, 2009, 11(10): 795.
[20]	Henrich D,Seebach C,Wilhelm K,et al.High dosage of simvastatin reduces T NF-alpha-induced apoptosis of endothelia progenitor cells but fails to prevent apoptosis induced by IL-1beta in vitro[J]. Surg Res, 2007, 142(1): 13.
[21]	薛亮, 范英昌, 李庆雯, 等. 丹酚酸B对离体培养内皮祖细胞VEGF、bEGF、mRNA表达及抗氧化酶活性的影响[J].中国老年学杂志, 2011, 31(2): 236.
[22]	李大勇,陈文娜,谷峰,等.疏肝活血方含药血清对大鼠骨髓源性内皮祖细胞血管新生相关基因表达的影响[J].中国现代中药,2010,12(3):30.
[23]	张喜成,何延政,李跃武,等. 补肾生血胶囊动员骨髓内皮祖细胞促进缺血肢体血管新生的研究[J].江苏中医药,2006,27(3):57.
[24]	George J, Goldstein E, Abashidze S, et al. Circulating endothelial progenitor cells in patients with unstable angina: association with systemic inflammation[J].Eur Heart J, 2004, 25(12): 1003.
[25]	宫建芳, 马华, 申静,等.芪红合剂含药血清对体外培养人外周血内皮祖细胞NO及NOS的影响[J].中西医结合心脑血管病杂志, 2010, 8(3): 312.
[26]	Guo WX, Yang QD, Liu YH, et al. Palmitic and linoleic acids impair endothelial progenitor cells by inhibition of akt/eNOS pathway[J].Archives of Medical Research,2008, 39 (4): 434.
[27]	陈图刚, 李鸣媛, 谭维羚, 等. 灯盏花素对内皮祖细胞数量、功能及iNOS的影响[J].实用中西医结合杂志, 2010, 10(4): 1.
[28]	陈图刚, 谢旭东, 陈红娟. 黄芪对内皮祖细胞数量与功能及其iNOS的影响[J].中药药理与临床, 2007, 23(6): 47.
[29]	顾俊,王长谦,范华骅,等.白藜芦醇对外周血内皮祖细胞功能的影响[J].心脏杂志,2006,18(6):617.
[30]	陈琴,王铭涵,江时森,等. 丹参多酚酸盐修复糖基化终产物引起的晚期EPCs功能障碍及其分子机制[J].中国中西医结合杂志,2010,30(6):630.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Progress on the mechanisms of protective effects on endothelial progenitor cells from natural medicines and their active compounds

1. Fujian University of Traditional Chinese Medicine, Fuzhou 350100, China

2. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2012-02-13

Rev Recd Date: 2012-05-27

Key words:

Abstract: The integrity and function of the endothelium played a key role in the prevention of cardiovascular diseases (CVDs). The maintenance of normal endothelial function not only depended on pre-existing endothelial cells, but also included the recruitment of endothelial progenitor cells (EPC), and EPC might serve as a therapeutic target of CVDs. Application of natural medicines and their active compounds in the treatment of CVDs, and their effects on EPC had been reported previously. The mechanisms underlying the protection of natural medicines and their active compounds on endothelial progenitor cells were summarized in this paper.

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Reference (30)

[1]	Asahara T, Murohara T, Sullivan A, et a1. Isolation of putative progenitor endothelial cells for angiogenesis[J].Science, 1997, 275(5302): 964.
[2]	Lu L, Zhou JZ, Wang L,et al. Effects of Xuezhikang and pravastatin on circulating endothelial progenitor cells in patients with essential hypertension[J].Chin J Integr Med. 2009, 15(4): 266.
[3]	Gao D, Wu LY, Jiao YH, et al. The effect of Xuefu Zhuyu Decoction on in vitro endothelial progenitor cell tube formation[J].Chin J Integr Med, 2010, 16(1): 50.
[4]	Gao D, Wu LY, Jiao YH, et al. Effects of Xuefu Zhuyu decoction on EPCs function[J].Zhong Yao Cai,2010, 33(7): 1129.
[5]	吴建祥, 梁春, 任雨笙, 等. 麝香保心丸对内皮祖细胞功能及分泌一氧化氮的影响[J].中国中草药结合杂志,2009, 29(6): 511.
[6]	Shi AW, Wang XB, Lu FX. Ginsenoside Rg1 promotes endothelial progenitor cell migration and proliferation[J].Acta Pharmacol Sin,2009, 30(3): 299.
[7]	季亢挺, 张怀勤, 唐疾飞, 等. 丹参对高胆固醇血症患者内皮祖细胞数量及功能的影响[J].中国中药杂志,2007, 32(12): 1214.
[8]	Chan YH, Lam TH, Lau KK, et al. Dietary intake of phytoestrogen is associated with increased circulating endothelial progenitor cells in patients with cardiovascular disease[J].Eur J Cardiovasc Prev Rehabil,2011, 18(3): 360.
[9]	王胜男, 叶攀, 敖杰男. 丹参素对过氧化氢所致人脐静脉内皮细胞损伤的保护作用研究[J].时珍国医国药, 2011, 22(1): 66.
[10]	Zhao GR, Zhang HM, Ye TX, et al. Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B[J].Food and Chemical Toxicology,2008, 46(1): 73.
[11]	吴丽元, 党西强, 何小解, 等. 儿茶素清除超氧阴离子对AngⅡ诱导的内皮祖细胞NO与eNOS表达及凋亡影响[J].中国当代儿科杂志, 2009, 11(6): 476.
[12]	朱军慧, 王兴祥, 陈君柱, 等. 高胆固醇对内皮祖细胞数量和功能的影响[J].中华内科杂志, 2004, 43(4): 261.
[13]	Vasa M, Fichtlscherer S, Aicher A, et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease[J].Circ Res, 2001, 89(1): E1.
[14]	Hamed S, Brenner B, Abassi Z, et al. Hyperglycemia and Oxidized-LDL exert a deleterious effect on Endothelial Progenitor Cell migration in Type 2 Diabetes Mellitus[J].Thrombosis Research, 2010, 126(3): 166.
[15]	Ji KT, Chai JD, Cheng X, et al. Danshen protects endothelial progenitor cells from oxidized low-density lipoprotein induced impairment[J]. Zhejiang Univ-SciB (Biomed & Biotechnol), 2010 , 11(8): 618.
[16]	Ridker PM, Glynn RJ, Henneken CH. C-reactive protein adds to the predictive value of total and HDL cholesterol In determining risk of first myocardial infarction[J].Circulation, 1998, 97(20): 2007.
[17]	崔斌, 黄岚, 宋耀明, 等.冠心病患者高敏C反应蛋白与循环内皮祖细胞的关系及临床意义[J].重庆医学, 2005, 34(9): 1344.
[18]	崔斌, 黄岚, 谭虎. C反应蛋白对内皮祖细胞部分生物学功能的影响及其机制的实验研究[J].中华心血管病杂志, 2008, 36(5): 435.
[19]	南景龙, 李建军. C反应蛋白通过CD32影响人内祖细胞分泌白细胞介素8[J].中华老年心脑血管病杂志, 2009, 11(10): 795.
[20]	Henrich D,Seebach C,Wilhelm K,et al.High dosage of simvastatin reduces T NF-alpha-induced apoptosis of endothelia progenitor cells but fails to prevent apoptosis induced by IL-1beta in vitro[J]. Surg Res, 2007, 142(1): 13.
[21]	薛亮, 范英昌, 李庆雯, 等. 丹酚酸B对离体培养内皮祖细胞VEGF、bEGF、mRNA表达及抗氧化酶活性的影响[J].中国老年学杂志, 2011, 31(2): 236.
[22]	李大勇,陈文娜,谷峰,等.疏肝活血方含药血清对大鼠骨髓源性内皮祖细胞血管新生相关基因表达的影响[J].中国现代中药,2010,12(3):30.
[23]	张喜成,何延政,李跃武,等. 补肾生血胶囊动员骨髓内皮祖细胞促进缺血肢体血管新生的研究[J].江苏中医药,2006,27(3):57.
[24]	George J, Goldstein E, Abashidze S, et al. Circulating endothelial progenitor cells in patients with unstable angina: association with systemic inflammation[J].Eur Heart J, 2004, 25(12): 1003.
[25]	宫建芳, 马华, 申静,等.芪红合剂含药血清对体外培养人外周血内皮祖细胞NO及NOS的影响[J].中西医结合心脑血管病杂志, 2010, 8(3): 312.
[26]	Guo WX, Yang QD, Liu YH, et al. Palmitic and linoleic acids impair endothelial progenitor cells by inhibition of akt/eNOS pathway[J].Archives of Medical Research,2008, 39 (4): 434.
[27]	陈图刚, 李鸣媛, 谭维羚, 等. 灯盏花素对内皮祖细胞数量、功能及iNOS的影响[J].实用中西医结合杂志, 2010, 10(4): 1.
[28]	陈图刚, 谢旭东, 陈红娟. 黄芪对内皮祖细胞数量与功能及其iNOS的影响[J].中药药理与临床, 2007, 23(6): 47.
[29]	顾俊,王长谦,范华骅,等.白藜芦醇对外周血内皮祖细胞功能的影响[J].心脏杂志,2006,18(6):617.
[30]	陈琴,王铭涵,江时森,等. 丹参多酚酸盐修复糖基化终产物引起的晚期EPCs功能障碍及其分子机制[J].中国中西医结合杂志,2010,30(6):630.

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Progress on the mechanisms of protective effects on endothelial progenitor cells from natural medicines and their active compounds

doi: 10.3969/j.issn.1006-0111.2013.01.003

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通讯作者: 陈斌, bchen63@163.com

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