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2013 Vol. 31, No. 1

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Application of ten independent component analysis methods in pharmaceutical analysis
SONG Qing, LU Feng
2013, 31(1): 1-4,74. doi: 10.3969/j.issn.1006-0111.2013.01.001
Abstract(3551) PDF (565KB)(205)
Abstract:
The principles and applications of ICA methods were reviewed. Firstly, a summary of the background and development prospects of the ICA were described, the definition, basic principles, and ten algorithms of ICA were briefly introduced,and then the p...
Recent progress on biological activity and synthesis of 2-substituted Benzofuran derivatives
CHEN Huan, LI Ke
2013, 31(1): 5-10,71. doi: 10.3969/j.issn.1006-0111.2013.01.002
Abstract:
Benzofuran derivatives were a series of attracting heterocyclic compounds with a variety of biological activity. Based on the recently published literatures, these derivatives had shown antitumor, antioxidant, calcium influx blockade, angiotensin II ...
Progress on the mechanisms of protective effects on endothelial progenitor cells from natural medicines and their active compounds
DONG Ya-fen, SHU Jing-jing, MA Jing, LI Fei, PENG Cheng, JIN Lei, XIE He-hui, ZHANG Chuan
2013, 31(1): 11-13,31. doi: 10.3969/j.issn.1006-0111.2013.01.003
Abstract(3341) PDF (374KB)(127)
Abstract:
The integrity and function of the endothelium played a key role in the prevention of cardiovascular diseases (CVDs). The maintenance of normal endothelial function not only depended on pre-existing endothelial cells, but also included the recruitment...
Advance in drug therapy of gout
XU Na, CHEN Hai-sheng
2013, 31(1): 14-18. doi: 10.3969/j.issn.1006-0111.2013.01.004
Abstract(4732) PDF (281KB)(743)
Abstract:
With the development of the living standard, the incidence of gout was rising and the trend of patient age with gout getting younger. Developing high-effective and low-adverse anti-gout drugs was a priority of the research agenda. At present, convent...
Progress on the multiple pharmacological activity and mechanism of statins
ZHAO Xin-bin, NI Min, TAO Xia
2013, 31(1): 19-21. doi: 10.3969/j.issn.1006-0111.2013.01.005
Abstract(4748) PDF (268KB)(440)
Abstract:
Statins were a mainstay in the treatment of hyperlipidemia and used in the primary and secondary prevention of coronary artery disease. Recent studies indicated that there were some cholesterol-independent or pleiotropic effects of statins, including...
The clinical features of drug-induced liver injury in elderly
TANG Xian-feng, SUN Jie, LU Ming-zhu
2013, 31(1): 22-23,66. doi: 10.3969/j.issn.1006-0111.2013.01.006
Abstract(3193) PDF (444KB)(171)
Abstract:
Drug-induced hepato-toxicity was an important reason for the liver disease in elderly,which was four times more common than in adults and might include all known liver disorders. Reports related to drug side effects were rare in people >60 years of a...
Elucidation of 10-hydroxy-7-methyl-homocamptothecin by electrospray ion trap mass spectrometry
CUI Xiao-ru, GUAN Xiao-duo, MIAO Zhen-yuan, ZHANG Wan-nian, FAN Guo-rong
2013, 31(1): 24-26,60. doi: 10.3969/j.issn.1006-0111.2013.01.007
Abstract(3867) PDF (824KB)(438)
Abstract:
Objective To analyze the fragments of 10-hydroxy-7-methyl- homocamptothecin (TOP-01) by electrospray ion trap mass spectrometry and deduce the MS/MS fragment pathway of it. Methods Samples were directly injected into the instrument and the fragmen...
Design, synthesis and antifungal activity of novel triazole derivatives
LI Yang-yang, LIU Hua, LIU Hong, ZHANG Yong-qiang, ZHANG Wan-nian, SHENG Chun-quan
2013, 31(1): 27-31. doi: 10.3969/j.issn.1006-0111.2013.01.008
Abstract:
Objective To design the novel triazole derivatives and test their in vitro antifungal activities on the basis of the molecular design model for rational optimization of azole drugs. Methods Ring-open reaction of the oxiranes was used to synthesize ...
Study on clarification process of Bairui oral liquid
YAN Jun, XUAN Wei-dong, BIAN Jun
2013, 31(1): 32-34. doi: 10.3969/j.issn.1006-0111.2013.01.009
Abstract(3623) PDF (408KB)(101)
Abstract:
Objective To establish a optimum clarification process of Bairui oral liquid with new ZTCI+1-Ⅱ natural clarifying agents. Methods The effects on clarification of Bairui oral liquid were evaluated based on the factors such as adding sequence, added...
Extracting method optimization and physical and chemical properties of polysaccharide in Bletilla striata
HAN Dan, WANG Yang-ping, BI Ya-jing, LIU Fu-qiang
2013, 31(1): 35-37. doi: 10.3969/j.issn.1006-0111.2013.01.010
Abstract(4326) PDF (341KB)(451)
Abstract:
Objective To establishing the best extraction technology of polysaccharide in Bletilla striata and researching its physical and chemical properties. Methods Water extraction and buck formulation, cellulose enzyme hydrolysis and ultrasonic extracti...
Proliferation inhibition of total alkaloids from Pinellia Ternata in human lung cancer cells
ZHOU Xi, TANG Ying, SUN Huan, WANG Qing-min, LEI Cheng-xiang
2013, 31(1): 38-41. doi: 10.3969/j.issn.1006-0111.2013.01.011
Abstract(3634) PDF (509KB)(329)
Abstract:
Objective To investigate the proliferation inhibition of total alkaloids from Pinellia ternate (TATP) in human lung cancer line A549. Methods The proliferation inhibition of human lung cancer cell line A549 treated with TATP was measured with meth...
Protective effect of total flavonoids in Herba Siegesbeckiae on cerebral ischemia in rats
LOU Yue-fen, LI Ying, HU Bin
2013, 31(1): 42-44. doi: 10.3969/j.issn.1006-0111.2013.01.012
Abstract:
Objective To study the protective effect and possible mechanism of total flavonoids in Herba Siegesbeckiae on focal cerebral ischemia in rats. Methods Sprague Dawley (SD) rats were randomly divided into 6 groups: sham operation group, model group, ...
Analysis of serum bile acid changes in patient of oral administration of UDCA after hepatocellular carcinoma resection
JIN Rou-nan, LI Le-le, GONG Chun-gui
2013, 31(1): 45-48. doi: 10.3969/j.issn.1006-0111.2013.01.013
Abstract(3166) PDF (419KB)(110)
Abstract:
Objective To analyze the serum bile acid changes in patient of oral administration of UDCA after hepatocellular carcinoma resection and provide reasonable recommendations for clinical staffs. Methods 89 cases with hepatocellular carcinoma after ta...
Effect of combined therapy with piperazine ferulate and benazepdl on urinary albumin excretion rate in patients with early diabetic nephropathy
TU Chuan-fa, WANG Li-jun, JIN Du, YANG Hong-wei, ZHANG You-you, MOU Xiao-yue
2013, 31(1): 49-50,56. doi: 10.3969/j.issn.1006-0111.2013.01.014
Abstract(3191) PDF (450KB)(115)
Abstract:
To explore the effect of combined therapy with piperazine ferulate and benazepdl on urinary albumin excretion rate (UAER) in patients with early diabetic nephropathy (DN). Methods A total of 164 children were included in the study, 82 of whom accep...
The clinical effect of Jiangzhi tablets on hyperlipidemia
WANG Li-jun, LIU Dong, SHEN Lei
2013, 31(1): 51-52,63. doi: 10.3969/j.issn.1006-0111.2013.01.015
Abstract:
Objective To observe the clinical efficacy and safety of Jiangzhi tablet in the treatment of hyperlipoidemia. Methods 117 patients of hyperlipoidemia were randomly divided into 3 groups. Treatment group (39 patients) were treated with Jiangzhi tab...
Study on the solubility and stability of curcumin in PEG-400
TONG Yong-tao, GAO Yong, GAO Bao-an, YUE Li-qun, CHEN Jian-ming
2013, 31(1): 53-56. doi: 10.3969/j.issn.1006-0111.2013.01.016
Abstract(4876) PDF (511KB)(542)
Abstract:
Objective To study the solubility and stability of curcumin in PEG-400 and screen the best suitable stabilizer to improve the autoclave stability. Methods Solubility determination was used to determine the solubility of curcumin in PEG-400.The sta...
Study on quality standard of Xiangping chaqing paiqian granules
DENG Zhao-hui, LIANG Tu-jin, HU Wen-jun
2013, 31(1): 57-60. doi: 10.3969/j.issn.1006-0111.2013.01.017
Abstract(3134) PDF (574KB)(263)
Abstract:
Objective To establish a quality standard for Xiangping chaqing paiqian granules. Methods Chemical methods were used to identify vitamin C in the granules. TLC methods were used to identify green tea extracts and chrysanthemum extracts. Chlorogenic...
Determination of Esomeprazole in dog plasma by LC-MS-MS
YANG Xiao-ying, MA Qi-zhen
2013, 31(1): 61-63. doi: 10.3969/j.issn.1006-0111.2013.01.018
Abstract(3190) PDF (537KB)(533)
Abstract:
Objective To establish a method for determining Esomeprazole in dog plasma by LC-MS-MS. Methods Diazepam was used as the internal standard,the samples were precipitated with acetonitril. Analytical column was Shim-pack XR-ODS (2 mm×100 mm, 5 μm). T...
Determination of doxapram hydrochloride glucose injection by HPLC
XUE Zhi-hong, WANG Sheng-hao, PAN Shi-ru
2013, 31(1): 64-66. doi: 10.3969/j.issn.1006-0111.2013.01.019
Abstract(3452) PDF (552KB)(387)
Abstract:
Objective To establish an HPLC method for determination of doxapram hydrochloride glucose injection. Methods COSMOSIL C18 (150 mm×4.6 mm,5 μm) column was adopted. The mobile phase consisted of 0.82 μg/L CH3COONa (using Glacial acetic acid adjust to...
Analysis and countermeasure of outpatient drug return in our hospital
WANG Xiao-jun
2013, 31(1): 67-68,77. doi: 10.3969/j.issn.1006-0111.2013.01.020
Abstract(3015) PDF (485KB)(257)
Abstract:
Objective To analyze the outpatient drug return in 2011 and promote rational drug use. Methods 1 905 prescriptions of drug return in our hospital between January and December in 2011 were collected. Based on The medical organization drug managemen...
The fault analysis and processing method of automatic oral drug dispensing system
WU Pei-zhi, HU Li-hui, LIU Li-juan, WENG Shao-min
2013, 31(1): 69-71. doi: 10.3969/j.issn.1006-0111.2013.01.021
Abstract:
Objective To provide references for the troubleshooting of automatic oral drug dispensing system in hospital pharmacy. Methods The specific reasons of the fault when using automatic oral drug dispensing system were analyzed, and the processing meth...
Investigation of antiepileptic drugs in 526 children with epilepsy
XU Jin, LI Jiong, HAN Lin
2013, 31(1): 72-74. doi: 10.3969/j.issn.1006-0111.2013.01.022
Abstract:
Objective To understand the use of antiepileptic drugs for children with epilepsy in our hospital and provide reference for clinical medication individualization. Methods The varieties of antiepileptic drugs, the blood drug levels and the situatio...
Cognizance of the subject after the occurrence of the adverse drug reaction
XU Qing-song
2013, 31(1): 75-77. doi: 10.3969/j.issn.1006-0111.2013.01.023
Abstract(3151) PDF (485KB)(103)
Abstract:
In the adverse drug reactions, who should be the one to be responsible for patient suffers, which had been controversial for long time. In the judicial practice, law court often judged hospital to take the responsibility based on the fairness doctrin...