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Volume 31 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(2): 81-85

LIU Yue, ZHAO Liang, LI Yan, ZHU Zhen-yu, CHAI Yi-feng. Advances in metabonomics of hepatocellular carcinoma[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 81-85. doi: 10.3969/j.issn.1006-0111.2013.02.001
Citation: LIU Yue, ZHAO Liang, LI Yan, ZHU Zhen-yu, CHAI Yi-feng. Advances in metabonomics of hepatocellular carcinoma[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 81-85. doi: 10.3969/j.issn.1006-0111.2013.02.001
shu

Advances in metabonomics of hepatocellular carcinoma

doi: 10.3969/j.issn.1006-0111.2013.02.001
  • 1.

    Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China

  • 3.

    Zhengchangzhuang Clinic, Logistics Department of PLA, Beijing 100141, China

  • Received Date: 2012-04-16
  • Rev Recd Date: 2012-09-20
  • Hepatocellular carcinoma (HCC) was one of the most common malignancies with high incidence and mortality which threatened human health. Integrating analytical technology of high throughput and high resolution with bioinformatics, metabonomics could investigate the organism on the level of metabolism, provide a unique insight into searching biomarkers for early diagnosis of HCC and exploring the mechanism of HCC. The advances of metabonomics studies on HCC in the recent years were reviewed in this paper which could provide the reference for further research.
  • [1] Hanahan D, Weinberg R. The hallmarks of cancer[J]. Cell, 2000, 100(1):57.
    [2] World Health Organization. mortality database, WHO statistical information system.available at http://www.who.int/whosis/en/.accessed March 19, 2008.
    [3] Kassahun W, Fangmann J, Harms J, et al. Liver Resection and Transplantation in the Management of Hepatocellular Carcinoma:A Review[J]. Exp Clin Transplant, 2006, 4(2):549.
    [4] El-Serag HB, Rudolph L. Hepatocellular carcinoma:Epidemiology and molecular carcinogenesis[J]. Gastroenterology, 2007, 132(7):2557.
    [5] Anthony P. Hepatocellular carcinoma:an overview[J]. Histopathology,2001, 39(2):109.
    [6] El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States[J]. New Eng J Med, 1999, 340(10):745.
    [7] El-Serag HB, Tran T, Everhart JE. Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma[J]. Gastroenterology, 2004, 126(2):460.
    [8] El-Serag H, Mason A, Key C. Trends in survival of patients with hepatocellular carcinoma between 1977 and 1996 in the United States[J]. Hepatology, 2001, 33(1):62.
    [9] Onodera H, Ukai K, Minami Y. Hepatocellular-Carcinoma Cases with 5-Year Survival and Prognostic Factors Affecting the Survival-Time[J]. Tohoku J Exp Med, 1995, 176(4):203.
    [10] Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast,and prostate cancer[J]. Science, 1997, 275(5308):1943.
    [11] Fields AC, Cotsonis G, Sexton D, et al. Survivin expression in hepatocel lular carcinoma:correlation with proliferation. prognostic parameters,and outcome[J]. Modern Pathology, 2004, 17(11):1378.
    [12] Furui J, Furukawa M, Kanematsu T. The low positive rate of serum alpha-fetoprotein levels in hepatitis C virus antibody-positive patients with hepatocellular carcinoma[J]. Hepatogastroenterology,1995, 42(5):445.
    [13] Nguyen MH, Keeffe EB. Screening for hepatocellular carcinoma[J]. J Clin Gastroenterol, 2002, 35(5 Suppl. 2):S86.
    [14] Peng YC, Chan CS, Chen GH. The effectiveness of serum alpha-fetoprotein level in anti-HCV positive patients for screening hepatocellular carcinoma[J]. Hepatogastroenterology, 1999, 46(30):3208.
    [15] Nicholson J, Lindon J, Holmes E. 'Metabonomics':understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data[J]. Xenobiotica, 1999, 29(11):1181.
    [16] Fiehn O. Metabolomics—the link between genotypes and phenotypes[J]. Plant Mol Biol,2002, 48(1-2):155.
    [17] Zhang F, Jia Z, Gao P, et al. Metabonomics study of urine and plasma in depression and excess fatigue rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry[J]. Mol BioSyst, 2010, 6(5):852.
    [18] Chen Y, Zhang R, Song Y, et al. RRLC-MS/MS-based metabonomics combined with in-depth analysis of metabolic correlation network:finding potential biomarkers for breast cancer[J]. Analyst, 2009, 134(10):2003.
    [19] Zhou J, Xu B, Huang J, et al. 1H NMR-based metabonomic and pattern recognition analysis for detection of oral squamous cell carcinoma[J]. Clinica Chimica Acta, 2009, 401(1-2):8.
    [20] Pasikanti KK, Esuvaranathan K, Ho PC, et al. Noninvasive urinary metabonomic diagnosis of human bladder cancer[J]. J Proteome Res, 2010, 9(6):2988.
    [21] Lindon J, Nicholson J, Holmes E. The handbook of metabonomics and metabolomics[M]. Amsterdam:elsevier BV,2007:201~226.
    [22] Schmidt C. Metabolomics takes its place as latest up-and-coming "omic" science[J]. J Natl Cancer Inst, 2004, 96(10):732.
    [23] Cao H, Huang H, Xu W, et al. Fecal metabolome pro?ling of liver cirrhosis and hepatocellular carcinoma patients by ultra performance liquid chromatography-mass spectrometry[J]. Analytica Chimica Acta, 2011, 691(1-2):68.
    [24] Yin P, Wan D, Zhao C, et al. A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry[J]. Mol BioSyst, 2009, 5(8):868.
    [25] Patterson AD, Maurhofer O, Beyoglu D, et al. Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling[J]. Cancer Res, 2011, 71(21):6590.
    [26] Gao H, Lu Q, Liu X, et al. Application of 1H NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis[J]. Cancer Sci,2009, 100(4):782.
    [27] Chen F, Xue J, Zhou L, et al. Identification of serum biomarkers of hepatocarcinoma through liquid chromatography/mass spectrometry-based metabonomic method[J]. Anal Bioanal Chem, 2011, 401(6):1899.
    [28] Shariff MIF, Ladep NG, Cox IJ, et al. Characterization of urinary biomarkers of hepatocellular carcinoma using magnetic resonance spectroscopy in a Nigerian population[J]. J Proteome Res, 2010, 9(2):1096.
    [29] Shariff MIF, Gomaa AI, Cox IJ, et al. Urinary metabolic biomarkers of hepatocellular carcinoma in an Egyptian population:a validation study[J]. J Proteome Res, 2011, 10(4):1828.
    [30] Xue R, Lin Z, Deng C, et al. A serum metabolomic investigation on hepatocellular carcinoma patients by chemical derivatization followed by gas chromatography/mass spectrometry[J]. Rapid Commun Mass Sp, 2008, 22(19):3061.
    [31] Chen T, Xie G, Wang X, et al. Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma[J]. Mol Cell Proteomics, 2011, 10(7).
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Advances in metabonomics of hepatocellular carcinoma

doi: 10.3969/j.issn.1006-0111.2013.02.001
  • 1. Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 2. Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
  • 3. Zhengchangzhuang Clinic, Logistics Department of PLA, Beijing 100141, China
  • Received Date: 2012-04-16
  • Rev Recd Date: 2012-09-20

Abstract: Hepatocellular carcinoma (HCC) was one of the most common malignancies with high incidence and mortality which threatened human health. Integrating analytical technology of high throughput and high resolution with bioinformatics, metabonomics could investigate the organism on the level of metabolism, provide a unique insight into searching biomarkers for early diagnosis of HCC and exploring the mechanism of HCC. The advances of metabonomics studies on HCC in the recent years were reviewed in this paper which could provide the reference for further research.

LIU Yue, ZHAO Liang, LI Yan, ZHU Zhen-yu, CHAI Yi-feng. Advances in metabonomics of hepatocellular carcinoma[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 81-85. doi: 10.3969/j.issn.1006-0111.2013.02.001
Citation: LIU Yue, ZHAO Liang, LI Yan, ZHU Zhen-yu, CHAI Yi-feng. Advances in metabonomics of hepatocellular carcinoma[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 81-85. doi: 10.3969/j.issn.1006-0111.2013.02.001
shu

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