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2013 Vol. 31, No. 2

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Advances in metabonomics of hepatocellular carcinoma
LIU Yue, ZHAO Liang, LI Yan, ZHU Zhen-yu, CHAI Yi-feng
2013, 31(2): 81-85. doi: 10.3969/j.issn.1006-0111.2013.02.001
Abstract(4135) PDF (379KB)(143)
Abstract:
Hepatocellular carcinoma (HCC) was one of the most common malignancies with high incidence and mortality which threatened human health. Integrating analytical technology of high throughput and high resolution with bioinformatics, metabonomics could i...
Advances in polymeric micelles for drug delivery and tumor targeting
WU Yun-tao, ZHANG Yi-yi
2013, 31(2): 86-89,115. doi: 10.3969/j.issn.1006-0111.2013.02.002
Abstract(3320) PDF (575KB)(500)
Abstract:
Some unique inherent properties of polymeric micelles, including small particle size, high stability, long residence time, and good biocompatibility allowed polymeric micelles to be used as drug carriers. In recent years, increasing reports about the...
The application of solid phase extraction in biological samples
LIU Zi-xiu, ZHOU Yan-ping, YONG Tai-ping, LI Yan-si, DAI Guo-liang, LU Yu
2013, 31(2): 90-93. doi: 10.3969/j.issn.1006-0111.2012.02.003
Abstract:
In biological samples, the concentration and efficacy of drugs had great correlation, especially in the plasma (or serum), the concentration of drugs was directly related to efficacy. There was a wealth of drug metabolites in the urine, which was als...
Progress on Human aldehyde dehydrogenase II and its agonists
TIAN Wei, WANG Tao, ZHENG Can-hui, DONG Guo-qiang, LV jia-guo, ZHU Ju
2013, 31(2): 94-97,112. doi: 10.3969/j.issn.1006-0111.2013.02.004
Abstract(4905) PDF (618KB)(335)
Abstract:
The aldehyde dehydrogenase II (ALDH2) could act as both esterase and dehydrogenase. The improvement of ALDH2 activity might reduce the damage caused by alcohol and ischemia and avoid the occurrence of some certain cancers. The outline of ALDH2 and it...
Modulation of combined-release behaviors from pulsatile release tablet
ZOU Hao, LIU Jun-jie, CHEN Yan, LU Ying, ZHANG Chuan, ZHONG Yan-qiang
2013, 31(2): 98-101,107. doi: 10.3969/j.issn.1006-0111.2013.02.005
Abstract(2631) PDF (624KB)(584)
Abstract:
Objective To design and evaluate a multifunctional and multiple unit oral DDS, which depends on the preparations of pulsatile release mini-tablets. Methods Based on the combinations of pulsatile release tablets, zero-order DDS could be obtained. V...
Design, synthesis and anti-HBV activity of novel 2-prindyl ketone derivatives
ZHANG Ming-Feng, LV Zhi-liang, LI Ke
2013, 31(2): 102-107. doi: 10.3969/j.issn.1006-0111.2013.02.006
Abstract(3354) PDF (634KB)(136)
Abstract:
Objective To design and synthesize the new 2-pyridyl ketone amide derivatives and test the antiviral activity. Methods According to the pharmacophore model, a new class of 2-pyridyl ketone amide derivatives was designed, which were synthesized by ...
Study on brand counterfeit drugs detection methods by Raman spectroscopy
WANG Ke-bing, GAO Qun, LI Hao, LU Feng
2013, 31(2): 108-112. doi: 10.3969/j.issn.1006-0111.2013.02.007
Abstract(3125) PDF (725KB)(566)
Abstract:
Objective To established a two-step discriminant method based on SVM and HQI or PCA, in which cephalexin capsules from several domestic manufacturers were used as tool drugs for counterfeits of brand drugs appear on the market. Method In the first s...
Determination of dopamine hydrochloride in prefilled syringe by HPLC-ECD
HUANG Juan, ZHU Quan-gang, ZHANG Ling-juan, CAO Jie
2013, 31(2): 113-115. doi: 10.3969/j.issn.1006-0111.2013.02.008
Abstract(2844) PDF (403KB)(343)
Abstract:
Objective To establish a HPLC-ECD method for determination of dopamine hydrochloride in prefilled syringe. Methods The determination was performed on a Diamonsil-C18 analytical column (250 mm×4.6 mm,5 μm) with the mobile phase consisting of methan...
Analysis on flavonoid constituents of Pueraria lobata by UHPLC-Q-TOFMS
ZHOU Yong-gang, WU Si, MAO Fei, WU Ting-ting, WU Hai-tang, CHAI Yi-feng
2013, 31(2): 116-119. doi: 10.3969/j.issn.1006-0111.2013.02.009
Abstract(3301) PDF (581KB)(278)
Abstract:
Objective To analyze chemical constituents of Pueraria lobata by ultrahigh pressure liquid chromatography-quadrupole-time of flight mass spectrometry (UHPLC-Q-TOFMS). Methods A ACQUITY UPLC HSS T3 (100 mm×2.1 mm, 1.8 μm) column was used to separate...
Synergistic and protective effects of extracts from Engelhardtia roxburghiana or Rhizoma Wenyujin Concisum on acute myocardial ischemia in Rats
TANG Qing-nian, WU Qian, TIAN Shu-juan, MAO Jun-qin
2013, 31(2): 120-123. doi: 10.3969/j.issn.1006-0111.2013.02.010
Abstract:
Objective To study the optimal combined use of extracts from Engelhardtia roxburghiana with Rhizoma Wenyujin Concisum on acute myocardial ischemia in rats. Methods Six combined treatment groups were designed according to the weighted modification ...
The exploration of infection situation and drug resistance of Non-gonococcal urethritis
LIU Yan-fen, LIU Rui, SONG Bang-lin
2013, 31(2): 124-125. doi: 10.3969/j.issn.1006-0111.2013.02.011
Abstract(2913) PDF (390KB)(178)
Abstract:
Objective To explore the infection situation and drug resistance of the non-gonococcal urethritis. Methods The samples from the patients during 2009-01/2011-03 in our hospital were sellected, and the specimens had been dealt with immediately, with...
Clinical efficacy of Jiangtang Mixture on diabetic peripheral Neuropathy
HUANG Qiu-ming, ZHAO Tao
2013, 31(2): 126-128,142. doi: 10.3969/j.issn.1006-0111.2013.02.012
Abstract(2832) PDF (558KB)(110)
Abstract:
Objective To evaluate the efficacy and explore the mechanism of Jiangtang Mixture in treatment of diabetic peripheral neuropathy (DPN). Methods 60 cases of DPN patients were randomly divided into treatment group and control group with 30 cases in ...
Comparison of two different methods for preparation inclusion compound of β-cyclodextrin with Peppermint Oil
DENG Jing-jing, XU Juan, WU Ye, CHEN Jun-shi, YANG Feng
2013, 31(2): 129-130,147. doi: 10.3969/j.issn.1006-0111.2013.02.013
Abstract(3431) PDF (489KB)(125)
Abstract:
Objective To compare the methods of saturated water solution and ultrasonic for preparation inclusion compound of β-cyclodextrin with peppermint oil. Methods After extraction of peppermint oil, the inclusion compound of β-cyclodextrin with pepperm...
The quality analysis on the dioxogen
YUAN Lin, LIU Xiao-yu, QIU Hai-qiang
2013, 31(2): 131-133. doi: 10.3969/j.issn.1006-0111.2013.02.014
Abstract(2819) PDF (514KB)(187)
Abstract:
Objective To evaluate the quality of dioxogen in the market of Jiangsu province. Methods The general quality of all samples was detected by methods of Chp 2005(VolumeⅡ) and Chp 2010(VolumeⅡ). Results Based on the standards, all of 99 samples were...
Determination of ursolic acid and oleanolic acid in Salvia chinensis Benth by HPLC
SHI Hong
2013, 31(2): 134-136. doi: 10.3969/j.issn.1006-0111.2013.02.015
Abstract(3342) PDF (486KB)(223)
Abstract:
Objective To establish a method for determination of ursolie acid and oleanolic acid contents in Salvia chinensis Benth. Methods HPLC-DAD was used;the column was Agilent HC18 (4.6 mm×250 mm,5μm);mobile phase was A:0.1%(v/v)formic acid solution,B:m...
The fingerprint analysis on Chuanshentong injection by HPLC
ZHAO Jing, CAO Hong, XING Jun-bo
2013, 31(2): 137-139. doi: 10.3969/j.issn.1006-0111.2013.02.016
Abstract(2972) PDF (528KB)(289)
Abstract:
Objective To establish the fingerprint analysis for quality evaluation index of of Chuanshentong injection. Methods The fingerprints were established by HPLC. The mobile phase was acetonitrile-0.1% aqueous Formic acid solution in a gradient elution...
Determination of hydroxysaffor yellow A in Yihe decoction by HPLC
SHA Ri-na, HE Chun-long, WANG Huan-yun
2013, 31(2): 140-142. doi: 10.3969/j.issn.1006-0111.2013.02.017
Abstract:
Objective To establish a RP-HPLC method for the determination of hydroxysaffor yellows A in Yihe decoction. Methods The separation was performed on a Yilite C18 column(250 mm×4.6 mm, 5 μm). The mobile phase was methanol-0.5% acetic acid(20:80) wit...
Cost-effectiveness analysis of three kinds of drugs for osteoporosis
LI Yu-qing
2013, 31(2): 143-144,150. doi: 10.3969/j.issn.1006-0111.2013.02.018
Abstract(3230) PDF (497KB)(100)
Abstract:
Objective To investigate economic effects of three kinds of drugs in treatment of osteoporosis. Methods 135 cases were divided into three groups, A group with alendronate sodium and vitamin D3 tablets 70 mg/2 800 IU, once a week, early morning,B gr...
Role of clinical thinking by clinical pharmacists in clinical practice
ZHENG Zhong-jian, SUI Yu-xia, HUANG Xu-hui, SUN Hong, ZHUANG Jie
2013, 31(2): 145-147. doi: 10.3969/j.issn.1006-0111.2013.02.019
Abstract:
Objective To discuss the role of clinical thinking by clinical pharmacists in clinical practice. Methods With the aid of clinical thinking,a series of clinical practice including medical history collection, drugs use education treatment schemes,ana...
Introduction and application of accurate drug preparation system for outpatient pharmacy
LIU Rui, HAN Jin, LIU Jun, XIE Jin, ZHU Shan-wei, WANG Shu-ling
2013, 31(2): 148-150. doi: 10.3969/j.issn.1006-0111.2013.02.020
Abstract(2970) PDF (478KB)(335)
Abstract:
Objective To reduce medical disputes in outpatient pharmacy for drug procurement mistake, improve the work efficiency, and offer the reference for the performance analysis in outpatient pharmacy. Methods The accurate drug preparation system for ou...
Thoughts on cultivation of Postgraduate in specialty of Social & Administrative Pharmacy
CHEN Jing, SHU Li-xin, GU Wen-hua, LI Jie-wei
2013, 31(2): 151-153,160. doi: 10.3969/j.issn.1006-0111.2013.02.021
Abstract(3168) PDF (616KB)(177)
Abstract:
Social & Administrative Pharmacy was an emerging inter-disciplinary,the postgraduate education of which was growing vigorously in recent years. The situation of the domestic and foreign-disciplinary postgraduate cultivation was compared in this paper...
Practice of construction and management in training system of innovative experiment in pharmacy undergraduate
WANG Xiao-yan, ZHANG Ling, FAN Li, SHA Kun, DAI Wei-quan, SUN Qin-yan
2013, 31(2): 154-157. doi: 10.3969/j.issn.1006-0111.2013.02.022
Abstract:
With innovation education as the goal, general education as the core, the status of undergraduate innovative experiment training in China and in American were summarized in this study, the organization structure, management mechanism, project selecti...
Observation of higher education of pharmacy in the Southern California University of of USA
WANG Pei, MIAO Chao-yu
2013, 31(2): 158-160. doi: 10.3969/j.issn.1006-0111.2013.02.023
Abstract(2710) PDF (506KB)(774)
Abstract:
Objective To discuss the current mode of pharmaceutical high education by visiting School of Pharmacy in Southern California University. Methods The pharmacy education system in the School of pharmacy in Southern California University was introduc...