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Volume 31 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(2): 120-123

TANG Qing-nian, WU Qian, TIAN Shu-juan, MAO Jun-qin. Synergistic and protective effects of extracts from Engelhardtia roxburghiana or Rhizoma Wenyujin Concisum on acute myocardial ischemia in Rats[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 120-123. doi: 10.3969/j.issn.1006-0111.2013.02.010
Citation: TANG Qing-nian, WU Qian, TIAN Shu-juan, MAO Jun-qin. Synergistic and protective effects of extracts from Engelhardtia roxburghiana or Rhizoma Wenyujin Concisum on acute myocardial ischemia in Rats[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 120-123. doi: 10.3969/j.issn.1006-0111.2013.02.010
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Synergistic and protective effects of extracts from Engelhardtia roxburghiana or Rhizoma Wenyujin Concisum on acute myocardial ischemia in Rats

doi: 10.3969/j.issn.1006-0111.2013.02.010
  • 1.

    The 181st Hospital of PLA, GuiLin 530000, China

  • 2.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 3.

    The 85th Hospital of PLA, Shanghai 200052, China

  • Received Date: 2012-06-26
  • Rev Recd Date: 2013-01-11
  • Objective To study the optimal combined use of extracts from Engelhardtia roxburghiana with Rhizoma Wenyujin Concisum on acute myocardial ischemia in rats. Methods Six combined treatment groups were designed according to the weighted modification method, acute myocardial ischemia rats were induced by coronary artery ligation. The size of myocardial infarction and the levels of LDH and CK in serum were measured to evaluating acute myocardium ischemia injury. The nonlinear mixed effect model (N0NMEM) was used to quantitatively assess the effects of combined use of drugs. Results Extracts from Engelhardtia roxburghiana or Rhizoma Wenyujin Concisum could protect myocardial cells, significantly reduce serum CK and LDH in acute myocardial ischemia rats. N0NMEM analysis showed that there were obvious synergistic effects of the combination of Engelhardtia roxburghiana exctract with Rhizoma Wenyujin Concisum exctract on myocardial ischemia. Conclusion Extracts from Engelhardtia roxburghiana or from Rhizoma Wenyujin Concisum had synergistic and protective effects on acute myocardial ischemia in rats.
  • [1] 潘照斌,李柴朝,廖月娥,等. 黄杞叶总黄酮对大鼠实验性脑缺血保护作用的研究[J]. 中国实验方剂学杂志,2011,17(5):223.
    [2] 胡东南,蒋才武,黄健军.黄杞叶挥发油化学成分的GC-MS分析[J]. 中国实验方剂学杂志,2011,17(21):49.
    [3] 姚国贤,韩 刚,喇万英,等. 姜黄及片姜黄中姜黄素在大鼠体内药动学过程的比较[J]. 中药材,2011,34(1):88.
    [4] Zheng QS, Sun RY. Quantitative analysis of drug compatibility by weighed modification method[J]. Acta Pharmacol Sin, 1999,20(11):1043.
    [5] 黄继汉,张 密,王 民,等.权重配方模型的非线性混合效应分析:一个药物相互作用研究实例[J]. 中国临床药理学与治疗学,2011,16(10):1121.
    [6] 葛迎利,宋海燕,张 莉,等. 基于权重配方法的降脂颗粒治疗非酒精性脂肪性肝病组分配伍优化研究[J]. 中西医结合肝病杂志,2011,21(6):363.
    [7] 杨 勇.益心康泰胶囊对冠状动脉结扎所致心肌缺血大鼠模型的保护作用[J]. 中外医学研究,2012,10(6):13.
    [8] 陆文铨,张国强,陈大贵,等. 丹参素对大鼠急性心肌缺血的保护作用[J]. 药学实践杂志,2010, 28(4):279
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Synergistic and protective effects of extracts from Engelhardtia roxburghiana or Rhizoma Wenyujin Concisum on acute myocardial ischemia in Rats

doi: 10.3969/j.issn.1006-0111.2013.02.010
  • 1. The 181st Hospital of PLA, GuiLin 530000, China
  • 2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 3. The 85th Hospital of PLA, Shanghai 200052, China
  • Received Date: 2012-06-26
  • Rev Recd Date: 2013-01-11

Abstract: Objective To study the optimal combined use of extracts from Engelhardtia roxburghiana with Rhizoma Wenyujin Concisum on acute myocardial ischemia in rats. Methods Six combined treatment groups were designed according to the weighted modification method, acute myocardial ischemia rats were induced by coronary artery ligation. The size of myocardial infarction and the levels of LDH and CK in serum were measured to evaluating acute myocardium ischemia injury. The nonlinear mixed effect model (N0NMEM) was used to quantitatively assess the effects of combined use of drugs. Results Extracts from Engelhardtia roxburghiana or Rhizoma Wenyujin Concisum could protect myocardial cells, significantly reduce serum CK and LDH in acute myocardial ischemia rats. N0NMEM analysis showed that there were obvious synergistic effects of the combination of Engelhardtia roxburghiana exctract with Rhizoma Wenyujin Concisum exctract on myocardial ischemia. Conclusion Extracts from Engelhardtia roxburghiana or from Rhizoma Wenyujin Concisum had synergistic and protective effects on acute myocardial ischemia in rats.

TANG Qing-nian, WU Qian, TIAN Shu-juan, MAO Jun-qin. Synergistic and protective effects of extracts from Engelhardtia roxburghiana or Rhizoma Wenyujin Concisum on acute myocardial ischemia in Rats[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 120-123. doi: 10.3969/j.issn.1006-0111.2013.02.010
Citation: TANG Qing-nian, WU Qian, TIAN Shu-juan, MAO Jun-qin. Synergistic and protective effects of extracts from Engelhardtia roxburghiana or Rhizoma Wenyujin Concisum on acute myocardial ischemia in Rats[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 120-123. doi: 10.3969/j.issn.1006-0111.2013.02.010
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