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ZHANG Guangyu, DU Jing, LIU Mengzhen, ZHU Danni, YAN Hui, LIU Chong. Protective effect and mechanisms of neostigmine in combination with anisodamine against pulmonary oxygen toxicity[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(10): 433-438, 444. doi: 10.12206/j.issn.2097-2024.202310049
Citation:
HUANG Qiu-ming, ZHAO Tao. Clinical efficacy of Jiangtang Mixture on diabetic peripheral Neuropathy[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 126-128,142. doi: 10.3969/j.issn.1006-0111.2013.02.012
Clinical efficacy of Jiangtang Mixture on diabetic peripheral Neuropathy
School of Medicine, Wuhan University, Wuhan 430071, China;Xiaogan Centre Hospital, Xiaogan 432000, China
2.
Xiaogan Centre Hospital, Xiaogan 432000, China
Received Date: 2012-09-18
Rev Recd Date:
2012-11-06
Abstract
Objective To evaluate the efficacy and explore the mechanism of Jiangtang Mixture in treatment of diabetic peripheral neuropathy (DPN). Methods 60 cases of DPN patients were randomly divided into treatment group and control group with 30 cases in each group. Two groups were all treated with a diet control, routine hypoglycemic therapy, the control group was treated with Methylcobalamin Tablet 0.5 mg, po, tid. While the treatment group was treated with Jiangtang Mixture 50 ml, po, tid, on the basis of the control group. The course of treatment was 4 weeks in each group. Before and after treatment, clinical signs and symptoms were observed and determined, including fasting plasma glucose (FPG), the 2 hours postprandial blood glucose (PPG2h), glycated hemoglobin (HbA1C), plasma viscosity (PV), endothelin (ET), nitric oxide (NO), and nerve conduction velocity (NCV). Results The total effective rate of the treatment group (86.67%) was significantly higher than that of the control group (63.33%)(P<0.05). There were significant differences in levels of the indexes, such as NCV、FPG、PPG2h、HbA1C、PV、ET and NO in the treatment group before and after treatment (P<0.05), but only in the four indexes, such as NCV、PV、ET and NO, the treatment group compared with the control group showed significantly differences after treatment (P<0.05). Adverse reactions of Jiangtang Mixture did not find in the observation period. Conclusion Jiangtang Mixture combined with Mecobalamine to treat DPN was safe and effective. The mechanism could be related to protect vascular endothelial cell, improve blood rheology, expand the peripheral microvascular, nourish the nerve with blood and oxygen supply, prevent or reverse impaired peripheral nerve fibers of DPN.
Mather KJ, Lteif A, Steinberg HO, et al. Interactions between endothelin and nitric oxide in the regulation of vascular tone in obesity and diabetes[J]. Diabetes,2004,53(8):2060.
Abstract: Objective To evaluate the efficacy and explore the mechanism of Jiangtang Mixture in treatment of diabetic peripheral neuropathy (DPN). Methods 60 cases of DPN patients were randomly divided into treatment group and control group with 30 cases in each group. Two groups were all treated with a diet control, routine hypoglycemic therapy, the control group was treated with Methylcobalamin Tablet 0.5 mg, po, tid. While the treatment group was treated with Jiangtang Mixture 50 ml, po, tid, on the basis of the control group. The course of treatment was 4 weeks in each group. Before and after treatment, clinical signs and symptoms were observed and determined, including fasting plasma glucose (FPG), the 2 hours postprandial blood glucose (PPG2h), glycated hemoglobin (HbA1C), plasma viscosity (PV), endothelin (ET), nitric oxide (NO), and nerve conduction velocity (NCV). Results The total effective rate of the treatment group (86.67%) was significantly higher than that of the control group (63.33%)(P<0.05). There were significant differences in levels of the indexes, such as NCV、FPG、PPG2h、HbA1C、PV、ET and NO in the treatment group before and after treatment (P<0.05), but only in the four indexes, such as NCV、PV、ET and NO, the treatment group compared with the control group showed significantly differences after treatment (P<0.05). Adverse reactions of Jiangtang Mixture did not find in the observation period. Conclusion Jiangtang Mixture combined with Mecobalamine to treat DPN was safe and effective. The mechanism could be related to protect vascular endothelial cell, improve blood rheology, expand the peripheral microvascular, nourish the nerve with blood and oxygen supply, prevent or reverse impaired peripheral nerve fibers of DPN.
ZHANG Guangyu, DU Jing, LIU Mengzhen, ZHU Danni, YAN Hui, LIU Chong. Protective effect and mechanisms of neostigmine in combination with anisodamine against pulmonary oxygen toxicity[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(10): 433-438, 444. doi: 10.12206/j.issn.2097-2024.202310049
Citation:
HUANG Qiu-ming, ZHAO Tao. Clinical efficacy of Jiangtang Mixture on diabetic peripheral Neuropathy[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 126-128,142. doi: 10.3969/j.issn.1006-0111.2013.02.012
Mather KJ, Lteif A, Steinberg HO, et al. Interactions between endothelin and nitric oxide in the regulation of vascular tone in obesity and diabetes[J]. Diabetes,2004,53(8):2060.
ZHANG Guangyu, DU Jing, LIU Mengzhen, ZHU Danni, YAN Hui, LIU Chong. Protective effect and mechanisms of neostigmine in combination with anisodamine against pulmonary oxygen toxicity[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(10): 433-438, 444. doi: 10.12206/j.issn.2097-2024.202310049
ZHANG Guangyu, DU Jing, LIU Mengzhen, ZHU Danni, YAN Hui, LIU Chong. Protective effect and mechanisms of neostigmine in combination with anisodamine against pulmonary oxygen toxicity[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(10): 433-438, 444. doi: 10.12206/j.issn.2097-2024.202310049
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