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Volume 31 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(2): 137-139

ZHAO Jing, CAO Hong, XING Jun-bo. The fingerprint analysis on Chuanshentong injection by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 137-139. doi: 10.3969/j.issn.1006-0111.2013.02.016
Citation: ZHAO Jing, CAO Hong, XING Jun-bo. The fingerprint analysis on Chuanshentong injection by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 137-139. doi: 10.3969/j.issn.1006-0111.2013.02.016
shu

The fingerprint analysis on Chuanshentong injection by HPLC

doi: 10.3969/j.issn.1006-0111.2013.02.016
  • 1.

    Department of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    Institute for Drug and Instrument Control Health Department, General Logistic Department of PLA, Beijing 100071, China

  • Received Date: 2012-07-03
  • Rev Recd Date: 2012-10-09
  • Objective To establish the fingerprint analysis for quality evaluation index of of Chuanshentong injection. Methods The fingerprints were established by HPLC. The mobile phase was acetonitrile-0.1% aqueous Formic acid solution in a gradient elution mode. The column temperature was maintained at 35℃. The flow rate was 1.0 ml /min,and detection wavelength was set at 281 nm. Results 11 common peaks were obtained in the fingerprint of 11 batches of Chuanshentong injection with the help of peaks match with Similarity Evaluation System for Chromatographic Fingerprint of TCM(Version 2004A). The similarity among 11 batches of Chuanshentong Injection was calculated more than 0.970.Principal components analyses was carried out to study the common HPLC fingerprint. Conclusion The method was simple,accurate and sensitive which could be used to evaluate the quality of Chuanshentong injection.
  • [1] 王 鹏,陆 涛,彭云飞,等. 川参通定位注射治疗慢性前列腺炎[J]. 实用医药杂志,2004,21(12):1113.
    [2] 国家药品管理监督局. 中药注射剂指纹图谱研究的技术要求(暂行)的通知[J].中成药,2000,22(10):671.
    [3] 许怀勇.中药指纹图谱在药品质量控制中的应用[J].医药导报,2009,29(2):218.
    [4] 中国药典2010版.一部[S].2010:38,71,124,144.
    [5] 唐旭利,刘 静,李国强,等. 丹参药材水溶性成分HPLC化学指纹图谱研究[J].中成药,2008,30(3):313.
    [6] 罗娟敏,肖 雪,梁琼麟,等. 丹红注射液指纹图谱研究[J]. 中成药,2011,33(8):1277.
    [7] 吴燕燕,尚明英,蔡少青. 当归的化学成分指纹图谱[J]. 药学学报,2008,43(7):728.
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The fingerprint analysis on Chuanshentong injection by HPLC

doi: 10.3969/j.issn.1006-0111.2013.02.016
  • 1. Department of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 2. Institute for Drug and Instrument Control Health Department, General Logistic Department of PLA, Beijing 100071, China
  • Received Date: 2012-07-03
  • Rev Recd Date: 2012-10-09

Abstract: Objective To establish the fingerprint analysis for quality evaluation index of of Chuanshentong injection. Methods The fingerprints were established by HPLC. The mobile phase was acetonitrile-0.1% aqueous Formic acid solution in a gradient elution mode. The column temperature was maintained at 35℃. The flow rate was 1.0 ml /min,and detection wavelength was set at 281 nm. Results 11 common peaks were obtained in the fingerprint of 11 batches of Chuanshentong injection with the help of peaks match with Similarity Evaluation System for Chromatographic Fingerprint of TCM(Version 2004A). The similarity among 11 batches of Chuanshentong Injection was calculated more than 0.970.Principal components analyses was carried out to study the common HPLC fingerprint. Conclusion The method was simple,accurate and sensitive which could be used to evaluate the quality of Chuanshentong injection.

ZHAO Jing, CAO Hong, XING Jun-bo. The fingerprint analysis on Chuanshentong injection by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 137-139. doi: 10.3969/j.issn.1006-0111.2013.02.016
Citation: ZHAO Jing, CAO Hong, XING Jun-bo. The fingerprint analysis on Chuanshentong injection by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 137-139. doi: 10.3969/j.issn.1006-0111.2013.02.016
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