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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(5): 330-333,350

CHENG Yan-qiong, ZHANG Hao, WANG Wei, GU Xiao-fei, LIU Ai-jun. New challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
Citation: CHENG Yan-qiong, ZHANG Hao, WANG Wei, GU Xiao-fei, LIU Ai-jun. New challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
shu

New challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases

doi: 10.3969/j.issn.1006-0111.2013.05.003
  • 1.

    Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2012-12-14
  • Rev Recd Date: 2013-04-08
  • The lack of folic acid which could cause hyperhomocysteine had revealed an obviously relationship with cardiovascular and cerebrovascular diseases. Plenty of studies had shown that hyperhomocysteine was an independent risk factor of cardiovascular and cerebrovascular diseases. Folic acid supplementation might be an effective method to decrease homocysteine and prevent cardiovascular and cerebrovascular diseases,while some studies question about it. So there was a new challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases.
  • [1] Collaboration HLT.Lowering blood homocysteine with folic acid based supplements:meta-analysis of randomized trials [J].BMJ,1998,316(7135):894.
    [2] Selhub J,Jacques PF,Wilson PW,et al.Vitamin status and intake as primary determinants of homocysteinemia in an elderly population[J].JAMA,1993,270(22):2693.
    [3] NOStuart JM,Derek L,Ian FW,et al.Folate, homocysteine, endothelial function and cardiovascular disease[J].Cire Res,2000,87(5):840.
    [4] Gottsater A,Forsblad J,Mattiasson I,et al.Decreasing plasma endothelin-1 and unchanged plasma neopterin during folate supplementation in hyperhomocysteinemia[J].Int Angiol,2002,21(2):158.
    [5] McCully KS.Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis[J].Am J Pathol,1969,56 (1):111.
    [6] Wilcken DE,Wilcken B.The pathogenesis of coronary artery disease. A possible role for methionine metabolism[J].J Clin Invest,1976,57 (4):1079.
    [7] Ward M.Homocysteine,folate and cardiovascular disease[J].Int J Vitam Nutr Res,2001,71(3):173.
    [8] Homocysteine Lowering Trialists' Collaboration.Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials[J].Am J Clin Nutr, 2005,82(4):806.
    [9] Homocysteine Studies Collaboration.Homocysteine and risk of ischemic heart disease and stroke:a meta-analysis[J].JAMA,2002,288(16): 2015.
    [10] Kelly PJ,Rosand J,Kistler JP,et al.Homocysteine, MTHFR 677C→T polymorphism, and risk of ischemic stroke:results of a meta-analysis[J].Neurology, 2002, 59(4):529.
    [11] Lewis SJ,Ebrahim S,Davey Smith G.Meta-analysis of MTHFR 677C→T polymorphism and coronary heart disease:does totality of evidence support causal role for homocysteine and preventive potential of folate[J].BMJ, 2005,331(7524):1053.
    [12] Sarkar PK, Lambert LA. Aetiology and treatment of hyperhomocysteinaemia causing ischaemic stroke[J].Int J Clin Pract,2001,55(4):262.
    [13] Oncel C,Demir S,Güler S,et al.Association between cholesterols,homocysteine and silent brain infarcts[J].Intern Med J,2009,39(3):150.
    [14] Homocysteine Lowering Trialists' Collaboration.Dose-dependent effects of folic acid on blood concentrations of homocysteine:A meta-analysis of the randomized trials[J].Am J Clin Nutr.2005,82(4): 806.
    [15] Fallon UB,Virtamo J,Young I,et al.Homocysteine and cerebral infarction in finnish male smokers[J].Stroke,2003,34(6):280.
    [16] Liu AJ,Guo JM,Xia WL,et al.The new strategies for the prevention of stroke[J].Clin Exp Pharmacol Physiol,2009,37(2):265.
    [17] Sánchez-Moreno C,Jiménez-Escrig A, Martín A.Stroke:roles of B vitamins,homocysteine and antioxidants[J].Nutr Res Rev,2009,22(1):49.
    [18] Woo KS,Chook P,Chan LL, et al. Long-term improvement in homocystein levels and arterial endothelial function after 1-year folic acid supplementation[J].Am J Med,2002,112(7):535.
    [19] Title IM,Cummings PM,Giddens K,et al.Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease[J].J Am Coll Cardiol,2000,36(3):758.
    [20] Chambers JC,Ueland PM,Obeid OA,et al.Improved vascular endothelial function after oral B vitamins: an effect mediated through reduced concentrations of free plasma homocysteine[J].Circulation,2000,102(20):2479.
    [21] Lonn E,Yusuf S,Arnold MJ.Homocysteine Lowering with folic acid and B vitamins in vascular disease[J].N Engl J Med,2006,54(15):1567.
    [22] SEARCH Study Collaborative Group,Bowman L,Armitage J,et al.Study of the effectiveness of additional reductions in cholesterol and homocysteine (SEARCH): characteristics of a randomized trial among 12 064 myocardial infarction survivors[J].Am Heart J,2007,154(5):815.
    [23] Ebbing M,Bleie O,Ueland PM,et al.Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography:a randomized controlled trial[J].JAMA,2008,300(7):795.
    [24] Albert CM,Cook NR,Gaziano JM,et al.Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial[J].JAMA, 2008,299(17):2027.
    [25] Bφnaa KH, Njφlstad I, Ueland PM, et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction[J].N Engl J Med, 2006, 354(15):1578.
    [26] Wrone EM, Hornberger JM,Zehnder JL,et al.Randomized trial of folic acid for prevention of cardiovascular events in end-stage renal disease[J].J Am Soc Nephrol,2004,15(2):420.
    [27] Liem AH,van Boven AJ,Veeger NJ,et al.Efficacy of folic acid when added to statin therapy in patients with hypercholesterolemia following acute myocardial infarction:a randomized pilot trial[J].Int J Cardiol,2004,93(2-3):175.
    [28] Zoungas S,McGrath BP,Branley P,et al.Cardiovascular morbidity and mortality in the Atherosclerosis and Folic Acid Supplementation Trial (ASFAST) in chronic renal failure: a multicenter, randomized, controlled trial[J].J Am Coll Cardiol 2006,47(6):1108.
    [29] Bazzano LA,Reynolds K,Holder KN,et al.Effect of folic acid supplementation on risk of cardiovascular diseases:a meta-analysis of randomized controlled trials[J].JAMA,2006,296(22):2720.
    [30] Martí-Carvajal AJ,Solà I,Lathyris D,et al. Homocysteine lowering interventions for preventing cardiovascular events[J].Cochrane Database Syst Rev. 2009, (4): CD006612.
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New challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases

doi: 10.3969/j.issn.1006-0111.2013.05.003
  • 1. Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 2. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2012-12-14
  • Rev Recd Date: 2013-04-08

Abstract: The lack of folic acid which could cause hyperhomocysteine had revealed an obviously relationship with cardiovascular and cerebrovascular diseases. Plenty of studies had shown that hyperhomocysteine was an independent risk factor of cardiovascular and cerebrovascular diseases. Folic acid supplementation might be an effective method to decrease homocysteine and prevent cardiovascular and cerebrovascular diseases,while some studies question about it. So there was a new challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases.

CHENG Yan-qiong, ZHANG Hao, WANG Wei, GU Xiao-fei, LIU Ai-jun. New challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
Citation: CHENG Yan-qiong, ZHANG Hao, WANG Wei, GU Xiao-fei, LIU Ai-jun. New challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
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