Therapy on male delayed puberty caused by hypogonadotropic hypogonadism by combination of growth hormone and gonadotropin

WANG Yu; FAN Yu-ping; HU Ye; HUANG Wen-qiang; TENG Xiao-ming

doi:10.3969/j.issn.1006-0111.2013.05.010

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Objective To evaluate the value and safety of combined therapy of growth hormone and gonadotropin on male delayed puberty caused by hypogonadotropic hypogonadism. Methods A retrospective analysis was undergoing in Shanghai First Maternity and Infant Hospital from 2010 Jun to 2012 May. 28 cases with male delayed puberty caused by hypogonadotropic hypogonadism were enrolled. The average age was (15.25±1.11) years. All the cases were given a combined therapy of human chorionic gonadotrophin, follicle stimulating hormone and growth hormone. After 3 months therapy, the growth condition such as sexual hormone levels, height, and volume of testis were recorded to inspect the treatment effect. Results All 28 cases had a follow-up visit. No short term complications occurred. The height and testosterone level was higher than which before therapy (P<0.05). And the volume of testis, follicle stimulating hormone and luteinizing hormone level were significantly higher than before the therapy. Conclusion Combined therapy of human chorionic gonadotrophin, follicle stimulating hormone and growth hormone could be a safe and effective method to treat male delayed puberty caused by hypogonadotropic hypogonadism.

Therapy on male delayed puberty caused by hypogonadotropic hypogonadism by combination of growth hormone and gonadotropin

Reproductive Medicine Center, Shanghai First Maternity and Infant Hospital, Tong-ji University School of Medicine, Shanghai 200040, China

Received Date: 2013-05-03

Rev Recd Date: 2013-07-31

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Abstract: Objective To evaluate the value and safety of combined therapy of growth hormone and gonadotropin on male delayed puberty caused by hypogonadotropic hypogonadism. Methods A retrospective analysis was undergoing in Shanghai First Maternity and Infant Hospital from 2010 Jun to 2012 May. 28 cases with male delayed puberty caused by hypogonadotropic hypogonadism were enrolled. The average age was (15.25±1.11) years. All the cases were given a combined therapy of human chorionic gonadotrophin, follicle stimulating hormone and growth hormone. After 3 months therapy, the growth condition such as sexual hormone levels, height, and volume of testis were recorded to inspect the treatment effect. Results All 28 cases had a follow-up visit. No short term complications occurred. The height and testosterone level was higher than which before therapy (P<0.05). And the volume of testis, follicle stimulating hormone and luteinizing hormone level were significantly higher than before the therapy. Conclusion Combined therapy of human chorionic gonadotrophin, follicle stimulating hormone and growth hormone could be a safe and effective method to treat male delayed puberty caused by hypogonadotropic hypogonadism.

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Reference (7)

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Therapy on male delayed puberty caused by hypogonadotropic hypogonadism by combination of growth hormone and gonadotropin

doi: 10.3969/j.issn.1006-0111.2013.05.010

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