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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(5): 366-367,383

YU Luyao, JIA Dan, SHEN Hui, SUN Xiaolei, QIN Luping, HAN Ting. Anti-inflammatory study on 9,9'-O-di-(E）-feruloyl-meso-5,5'-dimethoxysecoisolariciresinol (LCA), an active ingredient in Litsea cubeba (Lour.) Pers[J]. Journal of Pharmaceutical Practice and Service, 2020, 38(3): 216-220. doi: 10.12206/j.issn.1006-0111.201912159
Citation: ZHU Quan-gang, ZHANG Di, ZHOU Zhi-yun, PAN Yong-hua, YOU Ben-ming, LIU Ji-yong, GAO Shen. Preparation and determination of ropivacaine hydrochloride thermosensitive gel injection[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 366-367,383. doi: 10.3969/j.issn.1006-0111.2013.05.013
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Preparation and determination of ropivacaine hydrochloride thermosensitive gel injection

doi: 10.3969/j.issn.1006-0111.2013.05.013
  • 1.

    Department of Pharmacy, Shanghai Yueyang Affilated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

  • 2.

    Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2012-10-17
  • Rev Recd Date: 2013-03-13
  • Objective To prepare ropivacaine hydrochloride thermosensitive gel injection and establish the determination methods of contents. Methods Ropivacaine hydrochloride thermosensitive gel injection was prepared by cold methods with poloxamer as thermosensitive materials. The contents of ropivacaine hydrochloride were determined by RP-HPLC. Result The formulation contained 2% ropivacaine hydrochloride, poloxamer P407 and P188 (28:1) with phase-transition temperature of 37℃. Ropivacaine hydrochloride presented a good linearity in the range of 2.03~48.72 μg/ml (r=0.999 8), which had good precision, and reproducibility. The recovery rate of low, middle and high concentrations of ropivacaine hydrochloride were (99.58±0.20)%, (97.80±0.35)% and (103.60±0.63)%,n=3,respectively. The average contents of ropivacaine hydrochloride in three batches of sample were (98.92±0.35)%, (99.18±0.38)% and (98.72±0.62)%,n=3. Conclusion The quality of Ropivacaine hydrochloride thermosensitive gel injection with poloxamer as matrix could be controlled. It had a new development prospects for relieving pain.
  • [1] Akoglu E, Akkurt BC,Inanoglu K,et al. Ropivacaine compared to bupivacaine for post-tonsillectomy pain relief in children: A randomized controlled study[J].In J Pediatr Otorhinolaryngol,2006,70(7):1169.
    [2] 顼佳音, 杨洪军, 熊 欣, 等. 常见温度敏感型原位凝胶载体的研究进展[J]. 中国实验方剂学杂志, 2011,17(2):252.
    [3] Seo HJ,Kim JC.Effects of additives on phase transitions of Poloxamer 407/Poloxamer 188 mixture and release property of monoolein cubic phase containing the poloxamers[J].J Ind Eng Chem,2012,18(1):88.
    [4] 陈 钢,侯世祥,秦凌浩. 动态流变实验评价温敏凝胶的方法研究[J].中国药学杂志,2008,43(6):444.
    [5] 陆松伟,朱全刚,陈方剑,等.用RP-HPLC法测定三利乳膏中盐酸利多卡因的含量[J].药学服务与研究,2011,11(4),291.
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Preparation and determination of ropivacaine hydrochloride thermosensitive gel injection

doi: 10.3969/j.issn.1006-0111.2013.05.013
  • 1. Department of Pharmacy, Shanghai Yueyang Affilated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • 2. Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2012-10-17
  • Rev Recd Date: 2013-03-13

Abstract: Objective To prepare ropivacaine hydrochloride thermosensitive gel injection and establish the determination methods of contents. Methods Ropivacaine hydrochloride thermosensitive gel injection was prepared by cold methods with poloxamer as thermosensitive materials. The contents of ropivacaine hydrochloride were determined by RP-HPLC. Result The formulation contained 2% ropivacaine hydrochloride, poloxamer P407 and P188 (28:1) with phase-transition temperature of 37℃. Ropivacaine hydrochloride presented a good linearity in the range of 2.03~48.72 μg/ml (r=0.999 8), which had good precision, and reproducibility. The recovery rate of low, middle and high concentrations of ropivacaine hydrochloride were (99.58±0.20)%, (97.80±0.35)% and (103.60±0.63)%,n=3,respectively. The average contents of ropivacaine hydrochloride in three batches of sample were (98.92±0.35)%, (99.18±0.38)% and (98.72±0.62)%,n=3. Conclusion The quality of Ropivacaine hydrochloride thermosensitive gel injection with poloxamer as matrix could be controlled. It had a new development prospects for relieving pain.

YU Luyao, JIA Dan, SHEN Hui, SUN Xiaolei, QIN Luping, HAN Ting. Anti-inflammatory study on 9,9'-O-di-(E）-feruloyl-meso-5,5'-dimethoxysecoisolariciresinol (LCA), an active ingredient in Litsea cubeba (Lour.) Pers[J]. Journal of Pharmaceutical Practice and Service, 2020, 38(3): 216-220. doi: 10.12206/j.issn.1006-0111.201912159
Citation: ZHU Quan-gang, ZHANG Di, ZHOU Zhi-yun, PAN Yong-hua, YOU Ben-ming, LIU Ji-yong, GAO Shen. Preparation and determination of ropivacaine hydrochloride thermosensitive gel injection[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 366-367,383. doi: 10.3969/j.issn.1006-0111.2013.05.013
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