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LAI Liyong, XIA Tianshuang, YUE Xiaoqiang, XIN Hailiang. Mechanism of Artemisia annua L. in GIOP with kidney-yin deficiency based on network pharmacology[J]. Journal of Pharmaceutical Practice and Service, 2023, 41(11): 672-679. doi: 10.12206/j.issn.2097-2024.202204115
Citation:
ZHU Quan-gang, ZHANG Di, ZHOU Zhi-yun, PAN Yong-hua, YOU Ben-ming, LIU Ji-yong, GAO Shen. Preparation and determination of ropivacaine hydrochloride thermosensitive gel injection[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 366-367,383. doi: 10.3969/j.issn.1006-0111.2013.05.013
Preparation and determination of ropivacaine hydrochloride thermosensitive gel injection
Department of Pharmacy, Shanghai Yueyang Affilated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
2.
Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
Received Date: 2012-10-17
Rev Recd Date:
2013-03-13
Abstract
Objective To prepare ropivacaine hydrochloride thermosensitive gel injection and establish the determination methods of contents. Methods Ropivacaine hydrochloride thermosensitive gel injection was prepared by cold methods with poloxamer as thermosensitive materials. The contents of ropivacaine hydrochloride were determined by RP-HPLC. Result The formulation contained 2% ropivacaine hydrochloride, poloxamer P407 and P188 (28:1) with phase-transition temperature of 37℃. Ropivacaine hydrochloride presented a good linearity in the range of 2.03~48.72 μg/ml (r=0.999 8), which had good precision, and reproducibility. The recovery rate of low, middle and high concentrations of ropivacaine hydrochloride were (99.58±0.20)%, (97.80±0.35)% and (103.60±0.63)%,n=3,respectively. The average contents of ropivacaine hydrochloride in three batches of sample were (98.92±0.35)%, (99.18±0.38)% and (98.72±0.62)%,n=3. Conclusion The quality of Ropivacaine hydrochloride thermosensitive gel injection with poloxamer as matrix could be controlled. It had a new development prospects for relieving pain.
Akoglu E, Akkurt BC,Inanoglu K,et al. Ropivacaine compared to bupivacaine for post-tonsillectomy pain relief in children: A randomized controlled study[J].In J Pediatr Otorhinolaryngol,2006,70(7):1169.
Seo HJ,Kim JC.Effects of additives on phase transitions of Poloxamer 407/Poloxamer 188 mixture and release property of monoolein cubic phase containing the poloxamers[J].J Ind Eng Chem,2012,18(1):88.
1. Department of Pharmacy, Shanghai Yueyang Affilated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
2. Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
Abstract: Objective To prepare ropivacaine hydrochloride thermosensitive gel injection and establish the determination methods of contents. Methods Ropivacaine hydrochloride thermosensitive gel injection was prepared by cold methods with poloxamer as thermosensitive materials. The contents of ropivacaine hydrochloride were determined by RP-HPLC. Result The formulation contained 2% ropivacaine hydrochloride, poloxamer P407 and P188 (28:1) with phase-transition temperature of 37℃. Ropivacaine hydrochloride presented a good linearity in the range of 2.03~48.72 μg/ml (r=0.999 8), which had good precision, and reproducibility. The recovery rate of low, middle and high concentrations of ropivacaine hydrochloride were (99.58±0.20)%, (97.80±0.35)% and (103.60±0.63)%,n=3,respectively. The average contents of ropivacaine hydrochloride in three batches of sample were (98.92±0.35)%, (99.18±0.38)% and (98.72±0.62)%,n=3. Conclusion The quality of Ropivacaine hydrochloride thermosensitive gel injection with poloxamer as matrix could be controlled. It had a new development prospects for relieving pain.
LAI Liyong, XIA Tianshuang, YUE Xiaoqiang, XIN Hailiang. Mechanism of Artemisia annua L. in GIOP with kidney-yin deficiency based on network pharmacology[J]. Journal of Pharmaceutical Practice and Service, 2023, 41(11): 672-679. doi: 10.12206/j.issn.2097-2024.202204115
Citation:
ZHU Quan-gang, ZHANG Di, ZHOU Zhi-yun, PAN Yong-hua, YOU Ben-ming, LIU Ji-yong, GAO Shen. Preparation and determination of ropivacaine hydrochloride thermosensitive gel injection[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 366-367,383. doi: 10.3969/j.issn.1006-0111.2013.05.013
Akoglu E, Akkurt BC,Inanoglu K,et al. Ropivacaine compared to bupivacaine for post-tonsillectomy pain relief in children: A randomized controlled study[J].In J Pediatr Otorhinolaryngol,2006,70(7):1169.
Seo HJ,Kim JC.Effects of additives on phase transitions of Poloxamer 407/Poloxamer 188 mixture and release property of monoolein cubic phase containing the poloxamers[J].J Ind Eng Chem,2012,18(1):88.
LAI Liyong, XIA Tianshuang, YUE Xiaoqiang, XIN Hailiang. Mechanism of Artemisia annua L. in GIOP with kidney-yin deficiency based on network pharmacology[J]. Journal of Pharmaceutical Practice and Service, 2023, 41(11): 672-679. doi: 10.12206/j.issn.2097-2024.202204115
LAI Liyong, XIA Tianshuang, YUE Xiaoqiang, XIN Hailiang. Mechanism of Artemisia annua L. in GIOP with kidney-yin deficiency based on network pharmacology[J]. Journal of Pharmaceutical Practice and Service, 2023, 41(11): 672-679. doi: 10.12206/j.issn.2097-2024.202204115