Screening the best ratio of artesunate and ursolic acid for lipid-lowering

YE Yalin; WANG Yuliang; WANG Zejian; YIN Ming; XIN Hailiang; ZHANG Lei

doi:10.3969/j.issn.1006-0111.2014.03.008

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Objective To observe the effect of different doses unilateral and compound of artesunate and ursolic acid on lipid metabolism in rats' model, find out the best ratio of artesunate and ursolic acid. Methods Lipid metabolism disorders model was induced by feeding high fat diet in rat.The best ratio was screened through comparing the lipid level of rats ofdifferent groups. Results The results showed that Artesunate (high dose)+Ursolicacid (high dose) significantly reduced TG, CHO and LDL-C, increased HDL-C and H/L. Lipid-lowering effect was superior the positive drug fenofibrate, but also superior to the same dose of artesunate and ursolic acid alone. No significant effect of each test sample on the rat liver function was observed(P>0.05). Conclusion Artesunate and ursolic acid ratio of 1:1 had the best lipid-lowering effect, and the recommended dose was (50+50) mg/kg.

Screening the best ratio of artesunate and ursolic acid for lipid-lowering

1. NO.421 Hospital of PLA, Guangzhou 510310, China

2. School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China;School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China

3. School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China

4. School of Traditional;Chinese Medicine, Second Military Medical University, Shanghai 200433, China

5. School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2013-05-01

Rev Recd Date: 2013-09-12

Key words:

Abstract: Objective To observe the effect of different doses unilateral and compound of artesunate and ursolic acid on lipid metabolism in rats' model, find out the best ratio of artesunate and ursolic acid. Methods Lipid metabolism disorders model was induced by feeding high fat diet in rat.The best ratio was screened through comparing the lipid level of rats ofdifferent groups. Results The results showed that Artesunate (high dose)+Ursolicacid (high dose) significantly reduced TG, CHO and LDL-C, increased HDL-C and H/L. Lipid-lowering effect was superior the positive drug fenofibrate, but also superior to the same dose of artesunate and ursolic acid alone. No significant effect of each test sample on the rat liver function was observed(P>0.05). Conclusion Artesunate and ursolic acid ratio of 1:1 had the best lipid-lowering effect, and the recommended dose was (50+50) mg/kg.

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Reference (12)

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Screening the best ratio of artesunate and ursolic acid for lipid-lowering

doi: 10.3969/j.issn.1006-0111.2014.03.008

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