Advances in TOR pathway in <i>Candida albicans</i>

LIANG Huajun; YAN Lan; CAO Yongbing; JIANG Yuanying; YAN Tianhua

doi:10.3969/j.issn.1006-0111.2014.04.002

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2014 > 32(4): 246-249,287

LIANG Huajun, YAN Lan, CAO Yongbing, JIANG Yuanying, YAN Tianhua. Advances in TOR pathway in Candida albicans[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 246-249,287. doi: 10.3969/j.issn.1006-0111.2014.04.002

Citation:

LIANG Huajun, YAN Lan, CAO Yongbing, JIANG Yuanying, YAN Tianhua. Advances in TOR pathway in Candida albicans[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 246-249,287. doi: 10.3969/j.issn.1006-0111.2014.04.002

Advances in TOR pathway in Candida albicans

doi: 10.3969/j.issn.1006-0111.2014.04.002

1.
School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
2.
Center for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2013-01-23
Rev Recd Date: 2013-05-20

Abstract

The target of rapamycin (TOR), a Ser/Thr protein kinase of PIKKs (phosphatidylinositol kinase-related kinases), is the central factor of a highly conserved signaling pathway in eukaryotes, and regulates cell growth in response to nutrients, hormones, and stresses.It controls temporal growth by activating anabolic processes such as translation, ribosome biogenesis, protein synthesis, transportation of amino acid and metabolic enzymes.The advances in TOR pathway in the most pervasive human fungal pathogen Candida albicans.
- Candida albicans,
- target of rapamycin,
- rapamycin,
- virulence

References

[1]	Sehgal SN, Baker H, Vézina C. Rapamycin(AY-22,989), a new antifungal antibiotic.II. Fer-mentation, isolation and characterization[J]. J Antibiot, 1975, 28(19): 721-732.
[2]	马林, 万元胜, 陈东生. 他克莫司的临床应用[J]. 药物流行病学杂志, 2008, 17(1): 8-10.
[3]	Harding MW, Galat A, Uehling DE, et al. A receptor for the immuno-suppressant FK506 is a cistrans peptidyl-prolyl isomerase[J]. Nature, 1989, 341 (6244):758-760.
[4]	Heitman J, Movva NR, Hall MN. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast[J]. Scinece, 1991, 253(5022): 905-909.
[5]	Snydman DR. Shifting patterns in the epidemiology of nosocomial Candida infections[J]. Chest, 2003, 123(5 Supp1): 5.
[6]	周建党, 黄辉, 陈颖, 等. 四年间酵母样真菌感染的病原菌分布与耐药特征分析[J]. 中国微生态学杂志. 2007, 19 (2): 202-203.
[7]	路晓钦, 黎莉华, 周丽, 等. 白假丝酵母菌感染分布及耐药性分析[J]. 中国感染控制杂志,2007, 6 (6): 419-421.
[8]	吴文娟,胡绿荫,孙志华, 等. 获得性免疫缺陷综合征患者白假丝酵母分离株基因型及耐药性分析[J]. 检验医学,2007, 22(6): 684-687.
[9]	Dames SA, Mulet JM, Rathgeb-Szabo K, et al. The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cel-lular stability[J]. J Biol Chem, 2005, 280(21): 20558-20564.
[10]	Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism[J]. Cell, 2006, 124(3): 471-484.
[11]	Rosenbach A, Dignard D, Pierce JV, et al. Adaptations of Candida albicans for growth in the mammalian Intestinal tract[J]. Eukaryot Cell, 2010, 9(7): 1075-1086.
[12]	Uhl MA, Biery M, Craiget N, et al. Haploin sufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C.albicans[J]. EMBO, 2003, 22 (11): 2668-2678.
[13]	Binda M, Péli-Gulli MP, Bonfils G, et al. The Vam6 GEF controls TORC1 by activating the EGO complex[J]. Mol Cell, 2009, 35(5): 563-573.
[14]	Zakikhany K, Naglik JR, Schmidt-Westhausen A, et al. In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination[J]. Cell Microbiol, 2007, 9(12): 2938-2954.
[15]	Tsao CC, Chen YT, Lan CY. A small G protein Rhb1 and a GTP ase-activating protein Tsc2 involved in nitrogen starvation-induced morphogenesis and cell wall integrity of Candida albicans[J]. Fungal Genet Biol, 2009, 46(2): 126-136.
[16]	Zacchi LF, Gomez-Raja J, Davis DA. Mds3 regulates morphogenesis in Candida albicans through the TOR pathway[J]. Mol Cell Biol, 2010, 30(14): 3695-3710.
[17]	Lee CM, Nantel A, Jiang LH, et al. The serine/threonine protein phosphatase SIT4 modulates yeast-to-hypha morphogenesis and virulence in Candida albicans[J]. Mol Microbol, 2004, 51(3): 691-709.
[18]	Liao WL, RamÓn AM, Fonzi WA. GLN3 encodes a global regulator of nitrogen metabolism and virulence of Candida albicans[J]. Fungal Genet Biol, 2008, 45(4): 514-526.
[19]	Huber A, Bodenmiller B, Uotila A, et al. Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis[J]. Genes Dev, 2009, 23: 1929-1943.
[20]	Liu W, Zhao JW, Li XC, et al. The protein kinase CaSch9p is required for the cell growth, filamentation and virulence in the human fungal pathogen Candida albica[J]. FEMS Yeast Res, 2010, 10(4): 462-470.
[21]	Li H, Tsang CK, Watkins M, et al. Nutrient regulates Tor1 nuclear localization and association with rDNA promoter[J]. Nature, 2006, 442: 1058-1061.
[22]	Strugill TW, Cohen A, Diefenbacher M, et al. TOR1 and TOR2 have distinct locations in live cells[J]. Eukaryot Cell, 2008, 7(10): 1819-1830.
[23]	Kim JE, Chen J. Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation[J]. PNAS, 2000, 97(26):14340-14345.
[24]	Kojic EM, Darouiche RO. Candida infections of medical devices[J]. Clin Microbiol, 2004, 17(2): 255-267.
[25]	Bastidas RJ, Heitman J, Cardenas ME. The protein kinase Tor1 regulates adhesin gene expression in Candida albicans[J]. PLoS Pathol, 2009, 5(2): e1000294.
[26]	Tsuchimori N, Sharkey LL, Fonzi WA, et al. Reduced virulence of HWP1-deficient mutants of Candida albicans and their interactions with host cells[J]. Infect Immun, 2000, 68(4): 1997-2002.
[27]	Nobile CJ, Mitchell AP. Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p[J]. Curr Biol, 2005, 15(12): 1150-1155.
[28]	Lempiäinen H, Uotila A, Urban J, et al. Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling[J]. Mol Cell, 2009, 33(6): 704-716.
[29]	Rohde JR, Cardenas ME. Nutrient signaling through TOR kinases controls gene expression and cellular differentiation in fungi[J]. Curr Top Microbiol, 2004, 279: 53-72.
[30]	Rohde JR, Bastidas R, Puria R, et al. Nutritional control via Tor sinaling in Saccharomyces cerevisiae[J]. Curr Opin Microbiol, 2008, 11(2): 153-160.
[31]	Zurita-Martine SA, Cardenas ME. Tor and cyclic AMP-Protein kinase A:two parallel pathways regulating expression of genes required for cell growth[J]. Eukaryot Cell, 2005, 4(1): 63-71.
[32]	Pedruzzi I, Dubouloz F, Cameroni E, et al. TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0 [J]. Mol Cell, 2003, 12(6): 1607-1613.
[33]	Soulard A, Cohenl A, Hall MN. TOR signaling in invertebrates[J]. Curr Opin Cell Biol, 2009, 21(6): 825-836.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Advances in TOR pathway in Candida albicans

1. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China

2. Center for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2013-01-23

Rev Recd Date: 2013-05-20

Key words:

Abstract: The target of rapamycin (TOR), a Ser/Thr protein kinase of PIKKs (phosphatidylinositol kinase-related kinases), is the central factor of a highly conserved signaling pathway in eukaryotes, and regulates cell growth in response to nutrients, hormones, and stresses.It controls temporal growth by activating anabolic processes such as translation, ribosome biogenesis, protein synthesis, transportation of amino acid and metabolic enzymes.The advances in TOR pathway in the most pervasive human fungal pathogen Candida albicans.

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Reference (33)

[1]	Sehgal SN, Baker H, Vézina C. Rapamycin(AY-22,989), a new antifungal antibiotic.II. Fer-mentation, isolation and characterization[J]. J Antibiot, 1975, 28(19): 721-732.
[2]	马林, 万元胜, 陈东生. 他克莫司的临床应用[J]. 药物流行病学杂志, 2008, 17(1): 8-10.
[3]	Harding MW, Galat A, Uehling DE, et al. A receptor for the immuno-suppressant FK506 is a cistrans peptidyl-prolyl isomerase[J]. Nature, 1989, 341 (6244):758-760.
[4]	Heitman J, Movva NR, Hall MN. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast[J]. Scinece, 1991, 253(5022): 905-909.
[5]	Snydman DR. Shifting patterns in the epidemiology of nosocomial Candida infections[J]. Chest, 2003, 123(5 Supp1): 5.
[6]	周建党, 黄辉, 陈颖, 等. 四年间酵母样真菌感染的病原菌分布与耐药特征分析[J]. 中国微生态学杂志. 2007, 19 (2): 202-203.
[7]	路晓钦, 黎莉华, 周丽, 等. 白假丝酵母菌感染分布及耐药性分析[J]. 中国感染控制杂志,2007, 6 (6): 419-421.
[8]	吴文娟,胡绿荫,孙志华, 等. 获得性免疫缺陷综合征患者白假丝酵母分离株基因型及耐药性分析[J]. 检验医学,2007, 22(6): 684-687.
[9]	Dames SA, Mulet JM, Rathgeb-Szabo K, et al. The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cel-lular stability[J]. J Biol Chem, 2005, 280(21): 20558-20564.
[10]	Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism[J]. Cell, 2006, 124(3): 471-484.
[11]	Rosenbach A, Dignard D, Pierce JV, et al. Adaptations of Candida albicans for growth in the mammalian Intestinal tract[J]. Eukaryot Cell, 2010, 9(7): 1075-1086.
[12]	Uhl MA, Biery M, Craiget N, et al. Haploin sufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C.albicans[J]. EMBO, 2003, 22 (11): 2668-2678.
[13]	Binda M, Péli-Gulli MP, Bonfils G, et al. The Vam6 GEF controls TORC1 by activating the EGO complex[J]. Mol Cell, 2009, 35(5): 563-573.
[14]	Zakikhany K, Naglik JR, Schmidt-Westhausen A, et al. In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination[J]. Cell Microbiol, 2007, 9(12): 2938-2954.
[15]	Tsao CC, Chen YT, Lan CY. A small G protein Rhb1 and a GTP ase-activating protein Tsc2 involved in nitrogen starvation-induced morphogenesis and cell wall integrity of Candida albicans[J]. Fungal Genet Biol, 2009, 46(2): 126-136.
[16]	Zacchi LF, Gomez-Raja J, Davis DA. Mds3 regulates morphogenesis in Candida albicans through the TOR pathway[J]. Mol Cell Biol, 2010, 30(14): 3695-3710.
[17]	Lee CM, Nantel A, Jiang LH, et al. The serine/threonine protein phosphatase SIT4 modulates yeast-to-hypha morphogenesis and virulence in Candida albicans[J]. Mol Microbol, 2004, 51(3): 691-709.
[18]	Liao WL, RamÓn AM, Fonzi WA. GLN3 encodes a global regulator of nitrogen metabolism and virulence of Candida albicans[J]. Fungal Genet Biol, 2008, 45(4): 514-526.
[19]	Huber A, Bodenmiller B, Uotila A, et al. Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis[J]. Genes Dev, 2009, 23: 1929-1943.
[20]	Liu W, Zhao JW, Li XC, et al. The protein kinase CaSch9p is required for the cell growth, filamentation and virulence in the human fungal pathogen Candida albica[J]. FEMS Yeast Res, 2010, 10(4): 462-470.
[21]	Li H, Tsang CK, Watkins M, et al. Nutrient regulates Tor1 nuclear localization and association with rDNA promoter[J]. Nature, 2006, 442: 1058-1061.
[22]	Strugill TW, Cohen A, Diefenbacher M, et al. TOR1 and TOR2 have distinct locations in live cells[J]. Eukaryot Cell, 2008, 7(10): 1819-1830.
[23]	Kim JE, Chen J. Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation[J]. PNAS, 2000, 97(26):14340-14345.
[24]	Kojic EM, Darouiche RO. Candida infections of medical devices[J]. Clin Microbiol, 2004, 17(2): 255-267.
[25]	Bastidas RJ, Heitman J, Cardenas ME. The protein kinase Tor1 regulates adhesin gene expression in Candida albicans[J]. PLoS Pathol, 2009, 5(2): e1000294.
[26]	Tsuchimori N, Sharkey LL, Fonzi WA, et al. Reduced virulence of HWP1-deficient mutants of Candida albicans and their interactions with host cells[J]. Infect Immun, 2000, 68(4): 1997-2002.
[27]	Nobile CJ, Mitchell AP. Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p[J]. Curr Biol, 2005, 15(12): 1150-1155.
[28]	Lempiäinen H, Uotila A, Urban J, et al. Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling[J]. Mol Cell, 2009, 33(6): 704-716.
[29]	Rohde JR, Cardenas ME. Nutrient signaling through TOR kinases controls gene expression and cellular differentiation in fungi[J]. Curr Top Microbiol, 2004, 279: 53-72.
[30]	Rohde JR, Bastidas R, Puria R, et al. Nutritional control via Tor sinaling in Saccharomyces cerevisiae[J]. Curr Opin Microbiol, 2008, 11(2): 153-160.
[31]	Zurita-Martine SA, Cardenas ME. Tor and cyclic AMP-Protein kinase A:two parallel pathways regulating expression of genes required for cell growth[J]. Eukaryot Cell, 2005, 4(1): 63-71.
[32]	Pedruzzi I, Dubouloz F, Cameroni E, et al. TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0 [J]. Mol Cell, 2003, 12(6): 1607-1613.
[33]	Soulard A, Cohenl A, Hall MN. TOR signaling in invertebrates[J]. Curr Opin Cell Biol, 2009, 21(6): 825-836.

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Advances in TOR pathway in Candida albicans

doi: 10.3969/j.issn.1006-0111.2014.04.002

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通讯作者: 陈斌, bchen63@163.com

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Advances in TOR pathway in Candida albicans

doi: 10.3969/j.issn.1006-0111.2014.04.002

1. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China

2. Center for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

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Advances in TOR pathway in Candida albicans

doi: 10.3969/j.issn.1006-0111.2014.04.002

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References

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通讯作者: 陈斌, bchen63@163.com

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Related

Proportional views

Advances in TOR pathway in Candida albicans

doi: 10.3969/j.issn.1006-0111.2014.04.002

1. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China 2. Center for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

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1. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China

2. Center for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai 200433, China