2014 Vol. 32, No. 4
Display Method:
2014, 32(4): 241-245,265.
doi: 10.3969/j.issn.1006-0111.2014.04.001
Abstract:
Albumin is an ideal drug carrier, but its application was limited because of the shortcomings of short half-life and susceptible to enzymatic degradation in vivo.However, according to its structural features, albumin has a plurality of modification s...
Albumin is an ideal drug carrier, but its application was limited because of the shortcomings of short half-life and susceptible to enzymatic degradation in vivo.However, according to its structural features, albumin has a plurality of modification s...
2014, 32(4): 246-249,287.
doi: 10.3969/j.issn.1006-0111.2014.04.002
Abstract:
The target of rapamycin (TOR), a Ser/Thr protein kinase of PIKKs (phosphatidylinositol kinase-related kinases), is the central factor of a highly conserved signaling pathway in eukaryotes, and regulates cell growth in response to nutrients, hormones,...
The target of rapamycin (TOR), a Ser/Thr protein kinase of PIKKs (phosphatidylinositol kinase-related kinases), is the central factor of a highly conserved signaling pathway in eukaryotes, and regulates cell growth in response to nutrients, hormones,...
2014, 32(4): 250-253,260.
doi: 10.3969/j.issn.1006-0111.2014.04.003
Abstract:
The traditional Chinese herb Shancigu is derived from the dry tuber of Cremastra appendiculata(D.Don)Makino, Pleione bulbocodioides(Franch)Rolfe, Pleione yunnanensis Rolfe.The chemical composition and pharmacological effects of Shancigu were overview...
The traditional Chinese herb Shancigu is derived from the dry tuber of Cremastra appendiculata(D.Don)Makino, Pleione bulbocodioides(Franch)Rolfe, Pleione yunnanensis Rolfe.The chemical composition and pharmacological effects of Shancigu were overview...
2014, 32(4): 254-256,277.
doi: 10.3969/j.issn.1006-0111.2014.04.004
Abstract:
Objective Nano-structured lipid carriers (NLC) is a concerned research area in pharmaceutics, which as a novel drug delivery system to promote oral absorption of poorly soluble drugs.The literatures were reviewed to explore and summarize the mechani...
Objective Nano-structured lipid carriers (NLC) is a concerned research area in pharmaceutics, which as a novel drug delivery system to promote oral absorption of poorly soluble drugs.The literatures were reviewed to explore and summarize the mechani...
2014, 32(4): 257-260.
doi: 10.3969/j.issn.1006-0111.2014.04.005
Abstract:
Objective To review the newly developed solid self-microemulsifying drug delivery system(S-SMEDDS). Methods Relevant literatures at home and abroad in recent years were consulted and summarized. Results Solid self-microemulsions carrier, solidific...
Objective To review the newly developed solid self-microemulsifying drug delivery system(S-SMEDDS). Methods Relevant literatures at home and abroad in recent years were consulted and summarized. Results Solid self-microemulsions carrier, solidific...
2014, 32(4): 261-265.
doi: 10.3969/j.issn.1006-0111.2014.04.006
Abstract:
Objective To analyze the main chemical constituents of Moutan cortex by high performance liquid chromatography-quadrupole-time of flight mass spectrometry (HPLC-QTOFMS). Methods A CAPCELL PAK C18(3.0 mm×100 mm, 3 μm) column was used to do chromatog...
Objective To analyze the main chemical constituents of Moutan cortex by high performance liquid chromatography-quadrupole-time of flight mass spectrometry (HPLC-QTOFMS). Methods A CAPCELL PAK C18(3.0 mm×100 mm, 3 μm) column was used to do chromatog...
2014, 32(4): 266-269.
doi: 10.3969/j.issn.1006-0111.2014.04.007
Abstract:
Objective To evaluated the inhibitory effect of garcinia glycosides on growth of 8 kinds of human tumor cells in vivo by hollow fiber assay and confirm the reliability of hollow fiber assay in anticancer effect by the nude mice xenograft test. Metho...
Objective To evaluated the inhibitory effect of garcinia glycosides on growth of 8 kinds of human tumor cells in vivo by hollow fiber assay and confirm the reliability of hollow fiber assay in anticancer effect by the nude mice xenograft test. Metho...
2014, 32(4): 270-272,293.
doi: 10.3969/j.issn.1006-0111.2014.04.008
Abstract:
Objective To develop a method for determination of 13 kinds of bile acid in healthy people and patients with primary liver cancer by HPLC-MS. Methods Acetonitrile was used to precipitate protein in plasma samples.The separation was performed on a S...
Objective To develop a method for determination of 13 kinds of bile acid in healthy people and patients with primary liver cancer by HPLC-MS. Methods Acetonitrile was used to precipitate protein in plasma samples.The separation was performed on a S...
2014, 32(4): 273-277.
doi: 10.3969/j.issn.1006-0111.2014.04.009
Abstract:
Objective To optimize the prescription and preparation technology of finasteride dispersible tablets. Methods Wet granulation technique was applied to optimize the formulation and technology of finasteride tablets. Results The formulation of finas...
Objective To optimize the prescription and preparation technology of finasteride dispersible tablets. Methods Wet granulation technique was applied to optimize the formulation and technology of finasteride tablets. Results The formulation of finas...
2014, 32(4): 278-281.
doi: 10.3969/j.issn.1006-0111.2014.04.010
Abstract:
Objective To reduce the management risk of operational narcotics in the operation room. Methods System of information management for RFID turnover box was developed with RFID technology based on the establishment of narcotic operation pharmacy; sys...
Objective To reduce the management risk of operational narcotics in the operation room. Methods System of information management for RFID turnover box was developed with RFID technology based on the establishment of narcotic operation pharmacy; sys...
2014, 32(4): 282-283,317.
doi: 10.3969/j.issn.1006-0111.2014.04.011
Abstract:
Objective To validate the determination method of microbacteria limit of Shuitiaosan powder. Methods Plate counting method was used.The method of counting bacteria and mould was validated by the recovery rates with 5 control strains.The method of c...
Objective To validate the determination method of microbacteria limit of Shuitiaosan powder. Methods Plate counting method was used.The method of counting bacteria and mould was validated by the recovery rates with 5 control strains.The method of c...
2014, 32(4): 284-287.
doi: 10.3969/j.issn.1006-0111.2014.04.012
Abstract:
Objective To search for starfishes with hopoglycemic activity and orientate the bioactive fractions. Methods Firstly, the crude extracts of four starfishes were subjected to oral glucose tolerance test on normal and diabetic mice.And then the in vi...
Objective To search for starfishes with hopoglycemic activity and orientate the bioactive fractions. Methods Firstly, the crude extracts of four starfishes were subjected to oral glucose tolerance test on normal and diabetic mice.And then the in vi...
2014, 32(4): 288-289,296.
doi: 10.3969/j.issn.1006-0111.2014.04.013
Abstract:
Objective To establish a population pharmacokinetic (PPK) model of metformin in healthy Chinese subjects, and evaluate the effect of different physiological factors on pharmacokinetic parameters of metformin. Methods The preparation of pericardial ...
Objective To establish a population pharmacokinetic (PPK) model of metformin in healthy Chinese subjects, and evaluate the effect of different physiological factors on pharmacokinetic parameters of metformin. Methods The preparation of pericardial ...
2014, 32(4): 290-293.
doi: 10.3969/j.issn.1006-0111.2014.04.014
Abstract:
Objective To obtain the improved synthesis of imatinib mesylate. Methods 4-[(4-methyl-piperazin-1-yl) methyl] benzoyl chloride dihydrochloride and 4-methyl-N3-[4-(3-pyridyl) pyrimidin-2-yl]-1,3-phenylenediamine were used as starting raw material to...
Objective To obtain the improved synthesis of imatinib mesylate. Methods 4-[(4-methyl-piperazin-1-yl) methyl] benzoyl chloride dihydrochloride and 4-methyl-N3-[4-(3-pyridyl) pyrimidin-2-yl]-1,3-phenylenediamine were used as starting raw material to...
2014, 32(4): 294-296.
doi: 10.3969/j.issn.1006-0111.2014.04.015
Abstract:
Objective To determina the content of cucurbitacin B in cucurbitacins. Methods The highly effective liquid phase chromatography was used,with Waters Symmetry C18 (250 mm× 4.6 mm 5 μm) column.The mobile phase was acetonitrile-water (51:49), the flow...
Objective To determina the content of cucurbitacin B in cucurbitacins. Methods The highly effective liquid phase chromatography was used,with Waters Symmetry C18 (250 mm× 4.6 mm 5 μm) column.The mobile phase was acetonitrile-water (51:49), the flow...
2014, 32(4): 297-299,314.
doi: 10.3969/j.issn.1006-0111.2014.04.016
Abstract:
Objective To evaluate the efficacy of loading or non loading administration of levosimendan in the treatment of patients with refractory congestive heart failure (RCHF). Methods A randomized, open, control clinical trial was conducted in 40 patient...
Objective To evaluate the efficacy of loading or non loading administration of levosimendan in the treatment of patients with refractory congestive heart failure (RCHF). Methods A randomized, open, control clinical trial was conducted in 40 patient...
2014, 32(4): 300-301,306.
doi: 10.3969/j.issn.1006-0111.2014.04.017
Abstract:
Objective To discuss pharmaceutical care for patients with acute pancreatitis, investigate and expand the role of clinical pharmacists in the clinical treatment. Methods To prepare pharmaceutical care, medication guidance and interventions of life ...
Objective To discuss pharmaceutical care for patients with acute pancreatitis, investigate and expand the role of clinical pharmacists in the clinical treatment. Methods To prepare pharmaceutical care, medication guidance and interventions of life ...
2014, 32(4): 302-303,311.
doi: 10.3969/j.issn.1006-0111.2014.04.018
Abstract:
The whole pharmaceutical care package was given by clinical pharmacist to a patient with infective endocarditis and renal insufficiency.The pharmacist performed pharmaceutical care by analyzing the condition of the patient,evaluating and making treat...
The whole pharmaceutical care package was given by clinical pharmacist to a patient with infective endocarditis and renal insufficiency.The pharmacist performed pharmaceutical care by analyzing the condition of the patient,evaluating and making treat...
2014, 32(4): 304-306.
doi: 10.3969/j.issn.1006-0111.2014.04.019
Abstract:
Objective To analysis the major problems and the causes in the process of centralized purchasing of national essential drugs, and to give some effective solutions according to the price problems for ensuring the quality and regular supply of nationa...
Objective To analysis the major problems and the causes in the process of centralized purchasing of national essential drugs, and to give some effective solutions according to the price problems for ensuring the quality and regular supply of nationa...
2014, 32(4): 307-308,320.
doi: 10.3969/j.issn.1006-0111.2014.04.020
Abstract:
Objective To propose conceptual framework for the components of rapid response capabilities of emergency medicine supply and suggestions of rapid response capabilities establishment. Methods The components framework of rapid response capabilities o...
Objective To propose conceptual framework for the components of rapid response capabilities of emergency medicine supply and suggestions of rapid response capabilities establishment. Methods The components framework of rapid response capabilities o...
2014, 32(4): 309-311.
doi: 10.3969/j.issn.1006-0111.2014.04.021
Abstract:
Objective To analyze the utilization of antibiotics for special use in our hospital in order to provide references for rational use antibiotics in clinic. Methods The utilization of antibiotics for special use in our hospital from 2010 to 2011 was ...
Objective To analyze the utilization of antibiotics for special use in our hospital in order to provide references for rational use antibiotics in clinic. Methods The utilization of antibiotics for special use in our hospital from 2010 to 2011 was ...
2014, 32(4): 312-314.
doi: 10.3969/j.issn.1006-0111.2014.04.022
Abstract:
Objective Brief introduced the difference of pharmaceutical service between Denmark and China by personal experience. Methods Difference was elicited by the inspection among the main hospitals, logistic unit, pharmaceutical department of university...
Objective Brief introduced the difference of pharmaceutical service between Denmark and China by personal experience. Methods Difference was elicited by the inspection among the main hospitals, logistic unit, pharmaceutical department of university...
2014, 32(4): 315-317.
doi: 10.3969/j.issn.1006-0111.2014.04.023
Abstract:
Objective To evaluate the pharmacoeconomics effectiveness of two community-acquired pneumonia therapeutic treatments, and provide guidance for rational drug use. Methods Two therapeutic schemes were analyzed through cost-effectiveness analysis.Resu...
Objective To evaluate the pharmacoeconomics effectiveness of two community-acquired pneumonia therapeutic treatments, and provide guidance for rational drug use. Methods Two therapeutic schemes were analyzed through cost-effectiveness analysis.Resu...
Exploration of practical teaching in Chinese materia medica curriculum with military characteristics
2014, 32(4): 318-320.
doi: 10.3969/j.issn.1006-0111.2014.04.024
Abstract:
Objective As the only institution developing traditional Chinese medical talents in PLA, in view of the need of interdisciplinary traditional Chinese medical talents and preparation of military medical fighting, education of military characteristics...
Objective As the only institution developing traditional Chinese medical talents in PLA, in view of the need of interdisciplinary traditional Chinese medical talents and preparation of military medical fighting, education of military characteristics...
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