Inhibitory activity of α-glucosidase in four starfishes

ZHANG Gaiyun; FAN Lin; HOU Zhonghai; ZHANG Yubian; YANG Yanliu

doi:10.3969/j.issn.1006-0111.2014.04.012

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Objective To search for starfishes with hopoglycemic activity and orientate the bioactive fractions. Methods Firstly, the crude extracts of four starfishes were subjected to oral glucose tolerance test on normal and diabetic mice.And then the in vitro α-glucosidase activity assay was introduced to confirm the bioactive fractions. Results The crude extract of Asterias rollestoni could lower the blood glucose of normal and diabetic mice after 0.5 h and 1 h.Furthermore, its n-BuOH fraction exhibited potent α-glucosidase inhibitoary activity. Conclusion The n-BuOH extract of Asterias rollestoni had a potent α-glucosidase inhibitoary activity.

Inhibitory activity of α-glucosidase in four starfishes

1. Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, China

2. School of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China

Received Date: 2013-05-22

Rev Recd Date: 2013-09-14

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Abstract: Objective To search for starfishes with hopoglycemic activity and orientate the bioactive fractions. Methods Firstly, the crude extracts of four starfishes were subjected to oral glucose tolerance test on normal and diabetic mice.And then the in vitro α-glucosidase activity assay was introduced to confirm the bioactive fractions. Results The crude extract of Asterias rollestoni could lower the blood glucose of normal and diabetic mice after 0.5 h and 1 h.Furthermore, its n-BuOH fraction exhibited potent α-glucosidase inhibitoary activity. Conclusion The n-BuOH extract of Asterias rollestoni had a potent α-glucosidase inhibitoary activity.

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[1]	袁鑫, 耿越. 海星生物活性成分的研究进展[J]. 天然产物研究与开发, 2011, 23(B12): 268-271.
[2]	刘铁铮, 郭爱洁, 王桂春, 等. 海星化学成分的生物活性及应用研究进展[J]. 广东农业科学, 2011, 38(13): 122-125.
[3]	Lee SM. The effect of chronic alpha-glucosidase inhibition on diabetic nephropathy in the Db/Db mouse[J]. Diabetes, 1982, 31 (3): 249-254.
[4]	黄宗国.中国海洋生物种类与分布[M]. 北京: 海洋出版社, 1990, 705-708.
[5]	许东晖, 许实波.海洋新化合物A1998降血糖作用机制研究[J]. 中草药,1999, 30 (10): 752-755.
[6]	韦宝伟, 刘布鸣, 曾宪彪, 等. 木姜叶柯总黄酮对大小鼠血糖和糖耐量的影响[J]. 现代药物与临床, 2012, 27 (1): 19-22.
[7]	何敏, 吴锋, 徐济良. 灵芝多糖对小鼠糖耐量的影响 [J]. 南通医学院学报, 2004, 24 (4): 369-372.
[8]	杨倩, 张茜, 张德甫, 等. 11味中药提取物中α-葡萄糖苷酶抑制剂的筛选[J].时珍国医国药, 2011, 22 (12): 3011-3012.
[9]	Si MM, Lou JS, Zhou CX, et al. Insulin releasing and alpha-glucosidase inhibitory activity of ethyl acetate fraction of Acorus calamus in vitro and in vivo[J]. J Ethnopharmacol, 2010, 128(1): 154-159.
[10]	刘涛, 詹永成, 裴月湖. 罗氏海盘车中一个新的脑苷脂类化合物罗氏脑苷[D]. 中国天然药物, 2007, 5 (3): 179-181.

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Inhibitory activity of α-glucosidase in four starfishes

doi: 10.3969/j.issn.1006-0111.2014.04.012

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