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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2014  >  32(4): 288-289,296

SUN Xin, GU Yuanyuan, YANG Xueping, LIU Wei. To improve the preparation process of pericardial fixation fluid and study its stability[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 288-289,296. doi: 10.3969/j.issn.1006-0111.2014.04.013
Citation: SUN Xin, GU Yuanyuan, YANG Xueping, LIU Wei. To improve the preparation process of pericardial fixation fluid and study its stability[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 288-289,296. doi: 10.3969/j.issn.1006-0111.2014.04.013
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To improve the preparation process of pericardial fixation fluid and study its stability

doi: 10.3969/j.issn.1006-0111.2014.04.013

  • Department of Pharmacy, No.88 Hospital of PLA, Shandong Tai'an 271000, China

  • Received Date: 2013-07-10
  • Rev Recd Date: 2013-12-18
  • Objective To establish a population pharmacokinetic (PPK) model of metformin in healthy Chinese subjects, and evaluate the effect of different physiological factors on pharmacokinetic parameters of metformin. Methods The preparation of pericardial fixation liquid is divided into solution A (buffer solution) and solution B (glutaraldehyde solution), which were reserved in the refrigerator before used.Before the experiment, solution A and B were mixed evenly to make fresh pericardial fixation fluid.Stability of solution A and B before and after disinfection, solution B, pericardial fixation fluid at room temperature and 4℃ in the refrigerator were studied using pH meter and hydroxylamine salt method with pH value and the content as indexes. Results The decline of pH value and the content was slight after disinfection for both solution A and B within the prescribed scope.when glutaraldehyde was in alkaline condition after the mix of solution A and B, it was with strong bactericidal activity and pericardial fixation ability; stability study showed that pericardial fixation fluid was more stable in cold storage than at room temperature within one year. Conclusion The improved preparation process of pericardial fixation fluid is reasonable and feasible.The pericardial fixation fluid has good stability, and the quality guarantee period could be extended to one year.
  • [1] 陈新谦,金有豫,汤 光.新编药物学[M].17版.北京:人民卫生出版社,2011:839-840.
    [2] 王 莉,米志苏.戊二醛类消毒剂国内临床应用现状[J].中华医院感染学杂志,2003,13(1):99-100.
    [3] 陈卫国,肖桂珍,李长峰.加强消毒液质量监控, 确保临床消毒效果[J].中国药师,2000,3(5):286.
    [4] 陈渝军,张少文,管红珍,等.经典恒温法预测0.5%戊二醛溶液的稳定性[J].中国药房,2010,32:3069-3070.
    [5] 徐 莅.2%碱性戊二醛溶液的稳定性考察[J].传染病药学,1998,8(3):24-26.
    [6] 黄兴兰.心包固定液的制备及质量控制[J].职业与健康,2003,19(2):119-120.
    [7] 孔福明.戊二醛含量测定及稳定性验证[J].国际医药卫生导报,2005,12(11):94-95.
    [8] 中华人民共和国卫生部药政司.中国医院制剂规范(西药制剂)[M].北京:中国医药科技出版社,1995:16.
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To improve the preparation process of pericardial fixation fluid and study its stability

doi: 10.3969/j.issn.1006-0111.2014.04.013
  • Department of Pharmacy, No.88 Hospital of PLA, Shandong Tai'an 271000, China
  • Received Date: 2013-07-10
  • Rev Recd Date: 2013-12-18

Abstract: Objective To establish a population pharmacokinetic (PPK) model of metformin in healthy Chinese subjects, and evaluate the effect of different physiological factors on pharmacokinetic parameters of metformin. Methods The preparation of pericardial fixation liquid is divided into solution A (buffer solution) and solution B (glutaraldehyde solution), which were reserved in the refrigerator before used.Before the experiment, solution A and B were mixed evenly to make fresh pericardial fixation fluid.Stability of solution A and B before and after disinfection, solution B, pericardial fixation fluid at room temperature and 4℃ in the refrigerator were studied using pH meter and hydroxylamine salt method with pH value and the content as indexes. Results The decline of pH value and the content was slight after disinfection for both solution A and B within the prescribed scope.when glutaraldehyde was in alkaline condition after the mix of solution A and B, it was with strong bactericidal activity and pericardial fixation ability; stability study showed that pericardial fixation fluid was more stable in cold storage than at room temperature within one year. Conclusion The improved preparation process of pericardial fixation fluid is reasonable and feasible.The pericardial fixation fluid has good stability, and the quality guarantee period could be extended to one year.

SUN Xin, GU Yuanyuan, YANG Xueping, LIU Wei. To improve the preparation process of pericardial fixation fluid and study its stability[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 288-289,296. doi: 10.3969/j.issn.1006-0111.2014.04.013
Citation: SUN Xin, GU Yuanyuan, YANG Xueping, LIU Wei. To improve the preparation process of pericardial fixation fluid and study its stability[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 288-289,296. doi: 10.3969/j.issn.1006-0111.2014.04.013
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