YAN Jianwei. Clinical observation of levocarnitine in prevention from peripheral nerve toxicity caused by paclitaxel[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 372-373. doi: 10.3969/j.issn.1006-0111.2014.05.016
| Citation:
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YAN Jianwei. Clinical observation of levocarnitine in prevention from peripheral nerve toxicity caused by paclitaxel[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 372-373. doi: 10.3969/j.issn.1006-0111.2014.05.016
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Clinical observation of levocarnitine in prevention from peripheral nerve toxicity caused by paclitaxel
- Received Date: 2013-04-01
- Rev Recd Date:
2013-07-30
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Abstract
Objective To observe levocarnitine in prevention and treatment of peripheral nerve toxicity caused by paclitaxel. Methods 64 cancer patients treated with paclitaxel-based chemotherapy were randomly divided into two groups, the preventive treatment group and control group.The patients in the preventive treatment group were treated with paclitaxel chemotherapy and levocarnitine.The patients in the control group were treated with the same chemotherapy but without levocarnitine.The incidence rate of neurotoxicity between two groups were compared. Results The incidence rate of neurotoxicity in the preventive treatment group was lower than that of the control group(P<0.05). Conclusion Application of levocarnitine in paclitaxel-based chemotherapy could reduce the neurotoxicity caused by chemotherapy.
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