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Volume 33 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(2): 106-109,170

LI Wenqing, ZOU Hao, ZHONG Yanqiang. Analysis of problems on tumor-targeting drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 106-109,170. doi: 10.3969/j.issn.1006-0111.2015.02.003
Citation: LI Wenqing, ZOU Hao, ZHONG Yanqiang. Analysis of problems on tumor-targeting drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 106-109,170. doi: 10.3969/j.issn.1006-0111.2015.02.003
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Analysis of problems on tumor-targeting drug delivery system

doi: 10.3969/j.issn.1006-0111.2015.02.003

  • Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2014-01-14
  • Rev Recd Date: 2014-09-23
  • Objective To analyze the current problems on tumor-targeting nanoparticle drug delivery system. Methods Recent researches of tumor-targeting nanoparticle drug delivery system were collected, read and summarized. Results Three research fields on tumor-targeting nanoparticle drug delivery system were reviewed in this article. Conclusion Not only a deeper understanding of the human physiology and tumor biology, but changes in strategies and experimental methods are needed to make new achievements on nanoparticle drug delivery system.
  • [1] 傅刘鹏,徐 俊,黄思超,等. 叶酸脂质体对乳腺癌4T1细胞的体内靶向性研究[J].山东医药, 2010,50(7):23-25.
    [2] 高 芸,李少一,商雪莹,等. FAT10过表达对肝癌细胞HepG2侵袭及迁移能力的影响[J].实用预防医学, 2013,20(5):517-520.
    [3] Giovanna D, Maurizio D. Contemporary pre-clinical development of anticancer agents-What are the optimal preclinical models?[J].Eur J Cancer,2009,45(16):2768-2781.
    [4] Lu W, Xiong C, Zhang R, et al.Receptor-mediated transcytosis: a mechanism for active extravascular transport of nanoparticles in solid tumors[J]. J Control Release,2012, 161(3): 959-966.
    [5] Ruenraroengsak P, Cook JM, Florence AT. Nanosystem drug targeting: facing up to complex realities[J].J Control Release, 2010,141(3): 265-276.
    [6] Yoo HS,Park TG. Folate receptor targeted biodegradable polymeric doxorubicin micelles[J]. J Control Release, 2004,96(2): 273-283.
    [7] Chung YI,Kima JC,Kim YH,et al.The effect of surface functionalization of PLGA nanoparticles by heparin-or chitosan-conjugated Pluronie on tumor targeting[J].J Control Release,2010,143(3):374-382.
    [8] Kirpotin DB,Drummond DC, Shao Y,et al. Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models[J].Cancer Res,2006,66(13): 6732-6740.
    [9] Rooy I, Mastrobattista E, Storm G, et al. Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain[J]. J Control Release, 2011,150(1): 30-36.
    [10] Bareford LM, Swann PW. Endocytic mechanisms for targeted drug delivery[J]. Adv Drug Deliv Rev, 2007,59(8) :748-758.
    [11] Paulos CM,Reddy JA, Leamon CP, et al. Ligand binding and kinetics of folate receptor recycling in vivo: impact on receptor-mediated drug delivery[J]. Mol Pharmacol, 2004,66(6): 1406-1414.
    [12] Smet M, Heijman E, Langereis S,et al. Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: an in vivo proof of concept study[J].J Control Release, 2011,150(1): 102-110.
    [13] Chen H, Kim S, He W, et al. Fast release of lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo Forster resonance energy transfer imaging[J]. Langmuir, 2008,24(10): 5213-5217.
    [14] Chen H, Kim S, Li L, et al. Release of hydrophobic molecules from polymer micelles into cell membranes revealed by Forster resonance energy transfer imaging[J]. Proc Natl Acad Sci USA, 2008,105(18): 6596-6601.
    [15] Koo AN, Min KH, Lee HJ, et al.Tumor accumulation and antitumor efficacy of docetaxel-loaded core-shell-corona micelles with shell-specific redox-responsive cross-links[J]. Biomaterials, 2012,33(5): 1489-1499.
    [16] Ishida T, Ichihara M, Wang X, et al. Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes[J]. J Control Release, 2006,115(3): 243-250.
    [17] Lu W,Wan J,She Z,et al.Brain delivery property and accelerated blood clearance of cationic albumin conjugated pegylated nanoparticle[J].J Control Release,2007,118(1):38-53.
    [18] Park K. To PEGylate or not to PEGylate, that is not the question[J]. J Control Release, 2010,142(2): 147-148.
    [19] Cukierman E, Khan DR. The benefits and challenges associated with the use of drug delivery systems in cancer therapy[J]. Biochem Pharmacol, 2010,80(5): 762-770.
    [20] Grantab R, Sivananthan S, Tannock IF. The penetration of anticancer drugs through tumor tissue as a function of cellular adhesion and packing density of tumor cells[J]. Cancer Res, 2006,66(2): 1033-1039.
    [21] Netti PA, Berk DA, Swartz M A,et al. Role of etracellular matrix assembly in interstitial transport in solid tumors[J]. Cancer Res, 2000,60(9): 2497-2503.
    [22] Brown E, Mckee TD, Tomaso ED, et al. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation[J]. Nat Med, 2003,9(6): 796-800.
    [23] Ramanujan S, Pluen A, Mckee TD, et al. Diffusion and convection in collagen gels: implications for transport in the tumor interstitium[J]. Biophys J, 2002,83(3): 1650-1660.
    [24] Alexandrakis G, Brown E, Tong RT, et al. Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors[J]. Nat Med, 2004,10(2): 203-207.
    [25] Ernsting MJ, Murakami M, Roy A, et al. Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles[J]. J Control Release, 2013,172(3): 782-794.
    [26] Damia G, D'Incalci M. Contemporary pre-clinical development of anticancer agents-what are the optimal preclinical models[J]. Eur J Cancer, 2009,45(16): 2768-2781.
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Analysis of problems on tumor-targeting drug delivery system

doi: 10.3969/j.issn.1006-0111.2015.02.003
  • Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2014-01-14
  • Rev Recd Date: 2014-09-23

Abstract: Objective To analyze the current problems on tumor-targeting nanoparticle drug delivery system. Methods Recent researches of tumor-targeting nanoparticle drug delivery system were collected, read and summarized. Results Three research fields on tumor-targeting nanoparticle drug delivery system were reviewed in this article. Conclusion Not only a deeper understanding of the human physiology and tumor biology, but changes in strategies and experimental methods are needed to make new achievements on nanoparticle drug delivery system.

LI Wenqing, ZOU Hao, ZHONG Yanqiang. Analysis of problems on tumor-targeting drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 106-109,170. doi: 10.3969/j.issn.1006-0111.2015.02.003
Citation: LI Wenqing, ZOU Hao, ZHONG Yanqiang. Analysis of problems on tumor-targeting drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 106-109,170. doi: 10.3969/j.issn.1006-0111.2015.02.003
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