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Volume 33 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(2): 171-172

LÜ Jianfeng, LIU Hua, YE Aiqin, LIU Jun, DING Rongjie. Observation of glutathione to prevent oxaliplatin-induced hepatic lesion[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 171-172. doi: 10.3969/j.issn.1006-0111.2015.02.021
Citation: LÜ Jianfeng, LIU Hua, YE Aiqin, LIU Jun, DING Rongjie. Observation of glutathione to prevent oxaliplatin-induced hepatic lesion[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 171-172. doi: 10.3969/j.issn.1006-0111.2015.02.021
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Observation of glutathione to prevent oxaliplatin-induced hepatic lesion

doi: 10.3969/j.issn.1006-0111.2015.02.021

  • Taixing People's Hospital, Taixing 225400, China

  • Received Date: 2013-12-10
  • Rev Recd Date: 2014-03-17
  • Objective To observe the curative effect of magnesium isoglycyrrhizinate in prevention of liver injury induced by oxaliplatin. Methods The control group used oxaliplatin, leucovorin, 5-fluorouracil chemotherapy, the treatment group were treated with oxaliplatin, leucovorin, 5-fluorouracil chemotherapy and simultaneous magnesium isoglycyrrhizinate were used at the same time. With 28 d for 1 course of treatment, the treatment period consisted of 2-4 courses, observation of patients and the proportion of liver injury were made. Results In the control group, liver injury incidence rate was 44.4%, the rate of injury was 19.4% in treatment group, there was significant difference between the two groups (P<0.01). Conclusion Magnesium isoglycyrrhizinate could be effective in prevention of oxaliplatin induced liver injury.
  • [1] 叶爱琴,吕建峰,刘 华.草酸铂致肝损伤的临床观察[J].肿瘤防治研究,2007,34(10):783-784.
    [2] 孙 燕,周际昌.临床肿瘤内科手册[M].4版.北京:人民卫生出版社,2004:102.
    [3] Slade JH, Alattar ML, Fogelman DR, et al. Portal hypertension associated with oxaliplatin administration: clinical manifestations of hepatic sinusoidal injury[J].Clin Colorectal Cancer,2009,8(4): 225-230.
    [4] Overman MJ, Maru DM, Charnsangavej C, et al. Oxaliplatin-mediated increase in spleen size as a biomarker for the development of hepatic sinusoidal injury[J].J Clin Oncol,2010,28(15): 2549-2555.
    [5] Motoori S, Kawase T, Nishimura H, et al. Two cases of advanced colorectal cancer which demonstrated the reversibility of oxaliplatin-mediated increase in splenic volume[J].Gan To Kagaku Ryoho,2011,38(4): 677-680.
    [6] 陈玉强,洪节约,张雅雅,等.异甘草酸镁治疗肝癌动脉栓塞化疗肝损伤的临床研究[J].实用临床医药杂志,2010,14(17):15-17.
    [7] Mao YM,Zeng MD,Chen Y.Magnesium isoglycyrrhizinate in the treatment of chronic liver diseases:a randomized,doubleblind,multi-doses,active drug controlled,multi-center study[J].Zhonghua Gan Zang Bing Za Zhi,2009,17:847-851.
    [8] 赵艳娟,杨梓梅.异甘草酸镁治疗慢性重型乙型肝炎的临床疗效观察[J].临床肝胆病杂志,2010,26(5):524-526.
    [9] 董大勇.异甘草酸镁治疗慢性乙型肝炎的临床观察.实用临床医药杂志,2010,14(19):36-37.
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Observation of glutathione to prevent oxaliplatin-induced hepatic lesion

doi: 10.3969/j.issn.1006-0111.2015.02.021
  • Taixing People's Hospital, Taixing 225400, China
  • Received Date: 2013-12-10
  • Rev Recd Date: 2014-03-17

Abstract: Objective To observe the curative effect of magnesium isoglycyrrhizinate in prevention of liver injury induced by oxaliplatin. Methods The control group used oxaliplatin, leucovorin, 5-fluorouracil chemotherapy, the treatment group were treated with oxaliplatin, leucovorin, 5-fluorouracil chemotherapy and simultaneous magnesium isoglycyrrhizinate were used at the same time. With 28 d for 1 course of treatment, the treatment period consisted of 2-4 courses, observation of patients and the proportion of liver injury were made. Results In the control group, liver injury incidence rate was 44.4%, the rate of injury was 19.4% in treatment group, there was significant difference between the two groups (P<0.01). Conclusion Magnesium isoglycyrrhizinate could be effective in prevention of oxaliplatin induced liver injury.

LÜ Jianfeng, LIU Hua, YE Aiqin, LIU Jun, DING Rongjie. Observation of glutathione to prevent oxaliplatin-induced hepatic lesion[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 171-172. doi: 10.3969/j.issn.1006-0111.2015.02.021
Citation: LÜ Jianfeng, LIU Hua, YE Aiqin, LIU Jun, DING Rongjie. Observation of glutathione to prevent oxaliplatin-induced hepatic lesion[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 171-172. doi: 10.3969/j.issn.1006-0111.2015.02.021
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