Research advance of selective inhibitor of tumornecrosis factor receptor

JIANG Hailong; WANG Ningyuan; LU Yiming

doi:10.3969/j.issn.1006-0111.2015.05.003

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TNF signaling pathway was a valuable target, and anti-TNF drugs were successfully used to treat autoimmune and inflammatory diseases.But this therapy abrogate some beneficial TNF signaling, leading to increased risk of infection and malignancy, and the onset of new auto-immune diseases. Inhibiting the soluble TNF/TNFR1 axis while saving the beneficial transmembrane TNF/TNFR2 signaling untouched was a new approach.Because it inhibited the pathological effects of TNF and reduced the side effects, and opened the way for the treatment of other diseases in which TNFR2 inhibition was detrimental.The significance of the selective inhibition of TNFR1-mediated signaling pathways for TNF-related diseases was discussed and the mechanism of TNF identification TNFR was clarified, which might provide new ideas for the design of new drugs.

Research advance of selective inhibitor of tumornecrosis factor receptor

1. Department of Microbial and Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

2. Department of Microbial and Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;FuJian University of Traditional Chinese Medicine, Fuzhou 350108, China

Received Date: 2014-04-18

Rev Recd Date: 2014-11-03

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Abstract: TNF signaling pathway was a valuable target, and anti-TNF drugs were successfully used to treat autoimmune and inflammatory diseases.But this therapy abrogate some beneficial TNF signaling, leading to increased risk of infection and malignancy, and the onset of new auto-immune diseases. Inhibiting the soluble TNF/TNFR1 axis while saving the beneficial transmembrane TNF/TNFR2 signaling untouched was a new approach.Because it inhibited the pathological effects of TNF and reduced the side effects, and opened the way for the treatment of other diseases in which TNFR2 inhibition was detrimental.The significance of the selective inhibition of TNFR1-mediated signaling pathways for TNF-related diseases was discussed and the mechanism of TNF identification TNFR was clarified, which might provide new ideas for the design of new drugs.

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Research advance of selective inhibitor of tumornecrosis factor receptor

doi: 10.3969/j.issn.1006-0111.2015.05.003

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