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2015 Vol. 33, No. 5

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Gut microbiota and inflammatory bowel disease
HE Lijuan, ZHANG Jundong, AN Maomao, JIANG Yuanying
2015, 33(5): 385-388,422. doi: 10.3969/j.issn.1006-0111.2015.05.001
Abstract(4022) PDF (788KB)(588)
Abstract:
Inflammatory bowel disease is a chronic inflammation of the intestinal tract, which comprises two primary forms of Crohn's disease(CD) and ulcerative colitis(UC). Decades of studies have revealed that environmental factors, susceptibility genes, and ...
Study progress of Danshensu and its derivatives in cardiovascular mechanism
JIAO Yuqiang, LIU Wenbin, YUAN Xia, JIANG Yu, TIAN Lin, JIN Lei, ZHANG Chuan
2015, 33(5): 389-391,405. doi: 10.3969/j.issn.1006-0111.2015.05.002
Abstract(3945) PDF (807KB)(476)
Abstract:
Danshensu is one of the main water soluble active ingredients of Salvia miltiorrhiza, which has many pharmacological activities, especially in cardiovascular system. The cardiovascular pharmacological mechanism of Danshensu and its derivatives from t...
Research advance of selective inhibitor of tumornecrosis factor receptor
JIANG Hailong, WANG Ningyuan, LU Yiming
2015, 33(5): 392-395. doi: 10.3969/j.issn.1006-0111.2015.05.003
Abstract(4236) PDF (428KB)(686)
Abstract:
TNF signaling pathway was a valuable target, and anti-TNF drugs were successfully used to treat autoimmune and inflammatory diseases.But this therapy abrogate some beneficial TNF signaling, leading to increased risk of infection and malignancy, and t...
Research progress on Pheretima
ZHOU Xiao, JI Qian, ZHANG Hanming, ZHANG Lei
2015, 33(5): 396-400,410. doi: 10.3969/j.issn.1006-0111.2015.05.004
Abstract(6582) PDF (790KB)(720)
Abstract:
Pheretima is one kind of Traditional Chinese Medicine (TCM) with multiple pharmacological effects. Researches on chemical constituents, pharmacological effects, identification, artificial breeding, machining and quality evaluation of Pheretima were r...
Research methods and applications in network pharmacology
XUE Xiaochun, HU Jinhong
2015, 33(5): 401-405. doi: 10.3969/j.issn.1006-0111.2015.05.005
Abstract(10849) PDF (1356KB)(985)
Abstract:
Recently, network pharmacology was a pop emerging pharmacology branch. The theory of "multi-gene, multi-target" about network pharmacology was consistent with treatment of complex disease. Different from the traditional experimental methods about pha...
Sepration and antitumor activities of secondary metabolites from marine actinomycete Nocardiopsis sp. SCSIO 11492
SU Ruiqiang, LI Yan, PENG Kun, LI Jie, YANG Quan, YANG Xianwen
2015, 33(5): 406-410. doi: 10.3969/j.issn.1006-0111.2015.05.006
Abstract(3715) PDF (920KB)(186)
Abstract:
Objective To explore cytotoxic secondary metabolites from a marine actinomycete Nocardiopsis sp. SCSIO 11492. Methods Isolation and purification were carried out by column chromatography over silica gel, Sephadex LH-20, and ODS structures of the i...
Combination of wogonin with 5-fluorouracil exhibits antagonistic effect on human Hep-G2 hepatocellular carcinoma cells
CHEN Weizhong, CAI Jingbin, CHEN Xiaolan, CHEN Ruiqi, LI Xiajing, LIAO Lianming
2015, 33(5): 411-414. doi: 10.3969/j.issn.1006-0111.2015.05.007
Abstract:
Objective To investigate the antagonistic effect of wogonin in combination with 5-fluorouracil (5-FU) on the proliferation of human Hep-G2 hepatocellular carcinoma cells. Methods Human hepatocellular Hep-G2 cells were divided into experimental gro...
Influence of multidrug resistant gene polymorphisms and haplotype on blood concentration of tacrolimus in individuals in stable phases after renal transplantation
ZHANG Yanqing, CHEN Jinshan, LI Jinyu, LIN Xiuli, SHI Hekun, LIN Xiaofeng
2015, 33(5): 415-418. doi: 10.3969/j.issn.1006-0111.2015.05.008
Abstract:
Objective To study the relevance between the polymorphisms and haplotype of multidrug resistant gene (MDR1) and the ratio of blood concentration/dosage in individuals treated by tacrolimus in stable phases post renal transplantation, and to provide ...
Bioequivalence study on two terazosin hydrochloride tablets
ZHU Leilei, GUO Lixia, ZHAN Yan, QIU Furong, ZHAO Tongfang, YE Yujie, YUAN Wei'an, LI Anping, LI Minghua, SU Shufang, JIANG Jian
2015, 33(5): 419-422. doi: 10.3969/j.issn.1006-0111.2015.05.009
Abstract:
Objective To evaluate the bioequivalence of domestic and imported terazosin hydrochloride tablets after single oral dose. Methods It was a single center, randomized, open, cross-over trail design, 21 subjects were fasting oral administered of 2 mg...
Pharmaceutical studies on thermos sensitive insulin anal liquid suppository
LIU Dan, ZHAO Wencui, XIAO Qiusheng, WANG Yanping, ZHANG Qi, YANG Wenhui
2015, 33(5): 423-425. doi: 10.3969/j.issn.1006-0111.2015.05.010
Abstract(3579) PDF (977KB)(254)
Abstract:
Objective To study the pharmaceutical quality of the thermos sensitive insulin anal liquid suppository. Methods Orthogonal test method was used, the forming of a gelatum time, gel strength, bio-adhesive force, viscosity, gelation temperature were ...
Detection of malachite green in natural indigo by surface enhanced Raman spectroscopy based on monolithic column
ZHENG Binxing, LV Diya, FANG Fang, LIU Yanhua, LI Dan, LU Feng, XU Jiyang
2015, 33(5): 426-428,459. doi: 10.3969/j.issn.1006-0111.2015.05.011
Abstract:
Objective To develop a rapid SERS detection method based on monolithic column for detection of dye adulterated natural indigo. Methods The dyes in natural indigo were extracted and mixed with silver colloid. The spectra were recorded after applyin...
L-carnitine alleviating cisplatin induced acute kidney injury through serum metabolomics analysis
JI Songgang, WU Qiong, ZHU Zhenyu, DONG Xin, HONG Zhanying, CHAI Yifeng
2015, 33(5): 429-433. doi: 10.3969/j.issn.1006-0111.2015.05.012
Abstract:
Objective To explore specific variables related to cisplatin induced acute kidney injury, serum metabonomics techniques were applied and simultaneously the value of intervention effects of L-carnitine were appraised. Methods 19 mice were divided i...
Analysis of the low polarity components from Polygonum paleaceum by GC-MS
YANG Yiqian, ZHANG Wei, CHEN Haisheng
2015, 33(5): 434-435,444. doi: 10.3969/j.issn.1006-0111.2015.05.013
Abstract:
Objective To investigate the low polarity compounds from Polygonum paleaceum Wall. Methods The ethyl alcohol extracts of Polygonum paleaceum Wall were extracted with petroleum ether. The components were separated and identified by GC-MS and elucid...
Analysis of chemical constituents in Capparis spinosa by GC-MS
ZHOU Yangyun, FENG Xiaolu, WANG Yuliang, ZHANG Lei
2015, 33(5): 436-437,480. doi: 10.3969/j.issn.1006-0111.2015.05.014
Abstract(3224) PDF (808KB)(493)
Abstract:
Objective To analyze the chemical constituents in fruits of Capparis spinosa by GC-MS analysis. Methods The compounds were extracted from Capparis spinosa by 70% ethanol after smash. After extraction by petroleum ether (boiling range was from 60 t...
Determination of aloe-emodin,rhein,emodin,chrysophanol and physcion in Xinbaoshen tablets by HPLC
QIAO Liye, FANG Li, CAO Yanli, LU Yin, SU Hua, WANG Shudong
2015, 33(5): 438-440. doi: 10.3969/j.issn.1006-0111.2015.05.015
Abstract(4522) PDF (604KB)(516)
Abstract:
Objective To establish method of the determination of aloe-emodin,rhein,emodin,chrysophanol and physcion in Xinbaoshen tablet,for the production of quality protection. Methods HPLC was performed on a Lichrospher-C18 column(250 mm×4.6mm,5 μm)with th...
The sensitivity evaluation of Raman spectroscopy and near infrared spectroscopy; in toxic adulterant detection of pharmaceutical excipient
ZHANG Zhonghu, LI Hao, LI Jun, LU Feng
2015, 33(5): 441-444. doi: 10.3969/j.issn.1006-0111.2015.05.016
Abstract:
Objective To develop a rapid method for the detection of toxic adulterant (diethylene glycol) in pharmaceutical excipient (glycerol). Method The detection sensitivity of Raman/ near infrared (NIR) spectroscopy combined with moving window correlati...
Simultaneous determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in Maxing oral solution by HPLC
ZHANG Minxin, HUANG Aiwen, SONG Hongtao
2015, 33(5): 445-447. doi: 10.3969/j.issn.1006-0111.2015.05.017
Abstract(3369) PDF (563KB)(448)
Abstract:
Objective To establish an HPLC method for determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in Maxing oral solution. Methods Phenomenex Hydro-RP (250 mm×4.6 mm, 4 μm) was adopted. Acetonitnile (A) and 0.1% phosphonic acid ...
Determination of oleanolic acid and ursolic acid in Shanzhajing Jiangzhi tablet by HPLC
LIN Yinan, JIN Huizi, SU Juan
2015, 33(5): 448-450,466. doi: 10.3969/j.issn.1006-0111.2015.05.018
Abstract:
Objective To establish the quality standard for Shanzhajing Jiangzhi tablet by HPLC. Methods Samples were analyzed on a Agilent Zorbax SB C18 column(250 mm×4.6 mm,5 μm) with methanol and 0.06 mol/L ammonium acetate(85:15)as mobile phase at the flo...
Determination of the content of baicalin in Qiguanyan granules by HPLC
LIU Binguo, ZHANG Xinping
2015, 33(5): 451-452. doi: 10.3969/j.issn.1006-0111.2015.05.019
Abstract(3237) PDF (655KB)(519)
Abstract:
Objective To establish a method of HPLC for the determination of baicalin in Qiguanyan granules. Methods HPLC was performed on ZORBAX SB-C18(4.6 mm×150 mm,5 μm) column with mobile phase consisted of methanol-0.1% phosphoric acid (47:53) at ambient...
One case of double primary tumors with secondary acute leukemia induced by chemotherapy drugs and literature review
YANG Xijing, ZHOU Fuping, ZHANG Qian, QIAN Qijun
2015, 33(5): 453-456. doi: 10.3969/j.issn.1006-0111.2015.05.020
Abstract:
In recent years, with a large number of chemotherapy development, the incidence of secondary leukemia increased year by year,an acute myelomonocytic leukemia after chemotherapy and radiotherapy in 1 case of ovarian cancer and breast cancer was report...
Effect of S-adenosylmethionine (SAM) on the treatment of chronic hepatitis B with hyperbilirubinemia
WU Yamiao, JIANG Xiunong
2015, 33(5): 457-459. doi: 10.3969/j.issn.1006-0111.2015.05.021
Abstract(3405) PDF (789KB)(424)
Abstract:
Objective To evaluate the clinical efficiencies and safeties of S-adenosylmethionine (SAM) in treatment of 34 patients with chronic hepatitis B complicated hyperbilirubinemia. Methods Patients which meet the diagnostic criteria were randomized int...
Combine traditional Chinese and western medicine treatment of chronic stomach disease clinical efficacy research
XIAO Yong, PAN Yujie, XING Qi, LI Wei, JIANG Lifu
2015, 33(5): 460-462,476. doi: 10.3969/j.issn.1006-0111.2015.05.022
Abstract(3863) PDF (898KB)(520)
Abstract:
Objective To investigate the effectiveness of the Weishule granule therapy with rabeprazole particles associated chronic stomach. Methods 488 cases of chronic gastritis were divided into treatment group and control group. Control group: oral rabep...
Analysis of application of human albumin after hepatectomy for primary liver cancer
ZHAN Qi, LI Yueyue, WANG Xiaojun, CHEN Anni, GU Suli, ZHANG Guoqing
2015, 33(5): 463-466. doi: 10.3969/j.issn.1006-0111.2015.05.023
Abstract(3774) PDF (467KB)(519)
Abstract:
Objective To assess the use of human albumin (ALB) after hepatectomy in hepatocellular carcinoma patients in our hospital. Methods 150 hospital medical records from June 2012 to June 2013 were analyzed, which used the human serum albumin during th...
The correlation between the resistance rate of Acinetobacter baumannii and antimicrobial consumption
WU Jianjun, BAO Yingfei, ZHAO Yang, CAI Heping, YANG Zhangwei, ZHOU Jia, WANG Xuebin, CHEN Cuimin
2015, 33(5): 467-470. doi: 10.3969/j.issn.1006-0111.2015.05.024
Abstract:
Objective To analyze the relevance between the consumption of various antimicrobials and antimicrobial resistance of Acinetobacter baumanni in a grade three hospital during 2007-2010. Methods A retrospective analysis was performed to count and sor...
Establishment of descriptive indicators evaluation method for hospital pharmacy production efficiency
HUO Hua, LUAN Zhipeng, GU Hongshuang, HUANG Haibo
2015, 33(5): 471-473. doi: 10.3969/j.issn.1006-0111.2015.05.025
Abstract(3177) PDF (450KB)(450)
Abstract:
Objective To establish a method to objectively and easily evaluate the production efficiency of pharmacy division. Methods Data of the input and output of 25 military hospitals pharmacy were analyzed;indicators of descriptive evaluation on pharmac...
Analysis on potentially inappropriate medication of 2 000 cases of elderly diabetic patients in the out-patient department
LIN Jie, CHEN Lingdi, SU Yinfa
2015, 33(5): 474-476. doi: 10.3969/j.issn.1006-0111.2015.05.026
Abstract(3550) PDF (458KB)(532)
Abstract:
Objective To evaluate potentially inappropriate medication(PIM) use of elderly diabetic patients in the out-patient department. Methods Beers criteria (2012 Edition) was used as the basis for evaluation of prescription in 2 000 elderly diabetic ca...
Investigation on prescription dosage of TCM decoction pieces
LIU Duo, GU Yan, JIN Hao, XU Min, GU Wanxiang, QIAN Fang
2015, 33(5): 477-480. doi: 10.3969/j.issn.1006-0111.2015.05.027
Abstract(3466) PDF (469KB)(540)
Abstract:
Objective To find out the status of the prescription dosage of TCM decoction pieces in Jiading Hospital of Traditional Chinese Medicine(TCM). Methods 1 000 prescriptions in 2013 were extracted, frequency, number of drug overdosed, dosage of poison...