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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(5): 406-410

SU Ruiqiang, LI Yan, PENG Kun, LI Jie, YANG Quan, YANG Xianwen. Sepration and antitumor activities of secondary metabolites from marine actinomycete Nocardiopsis sp. SCSIO 11492[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 406-410. doi: 10.3969/j.issn.1006-0111.2015.05.006
Citation: SU Ruiqiang, LI Yan, PENG Kun, LI Jie, YANG Quan, YANG Xianwen. Sepration and antitumor activities of secondary metabolites from marine actinomycete Nocardiopsis sp. SCSIO 11492[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 406-410. doi: 10.3969/j.issn.1006-0111.2015.05.006
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Sepration and antitumor activities of secondary metabolites from marine actinomycete Nocardiopsis sp. SCSIO 11492

doi: 10.3969/j.issn.1006-0111.2015.05.006
  • 1.

    Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China

  • 2.

    Instrument Department, No. 413 Hospital of PLA, Zhoushan 510301, China

  • 3.

    CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China

  • Received Date: 2014-12-31
  • Rev Recd Date: 2015-04-09
  • Objective To explore cytotoxic secondary metabolites from a marine actinomycete Nocardiopsis sp. SCSIO 11492. Methods Isolation and purification were carried out by column chromatography over silica gel, Sephadex LH-20, and ODS structures of the isolates were identified mainly by NMR spectroscopic data. And cytotoxic bioassay was performed using MTT method. Results Five compounds were identified as 2'-deoxyadenosine ( 1 ), 2'-deoxythymidine ( 2 ), 2'-deoxyuidine ( 3 ), uridine ( 4 ), 1-O-palmitoyl-3-d-galactosyl-sn-glycerol spongilipid ( 5 ). Compound 5 exhibited weak cytotoxic activity with IC50 value of 10.9 μmol/L. Conclusion Five compounds were obtained from a marine actinomycete Nocardiopsis sp. SCSIO 11492. All five compounds were reported for the first time from this genus. Compound 5 could be the bioactive compound responsible for the cytotoxic activity of Nocardiopsis sp. SCSIO 11492.
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Sepration and antitumor activities of secondary metabolites from marine actinomycete Nocardiopsis sp. SCSIO 11492

doi: 10.3969/j.issn.1006-0111.2015.05.006
  • 1. Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
  • 2. Instrument Department, No. 413 Hospital of PLA, Zhoushan 510301, China
  • 3. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
  • Received Date: 2014-12-31
  • Rev Recd Date: 2015-04-09

Abstract: Objective To explore cytotoxic secondary metabolites from a marine actinomycete Nocardiopsis sp. SCSIO 11492. Methods Isolation and purification were carried out by column chromatography over silica gel, Sephadex LH-20, and ODS structures of the isolates were identified mainly by NMR spectroscopic data. And cytotoxic bioassay was performed using MTT method. Results Five compounds were identified as 2'-deoxyadenosine ( 1 ), 2'-deoxythymidine ( 2 ), 2'-deoxyuidine ( 3 ), uridine ( 4 ), 1-O-palmitoyl-3-d-galactosyl-sn-glycerol spongilipid ( 5 ). Compound 5 exhibited weak cytotoxic activity with IC50 value of 10.9 μmol/L. Conclusion Five compounds were obtained from a marine actinomycete Nocardiopsis sp. SCSIO 11492. All five compounds were reported for the first time from this genus. Compound 5 could be the bioactive compound responsible for the cytotoxic activity of Nocardiopsis sp. SCSIO 11492.

SU Ruiqiang, LI Yan, PENG Kun, LI Jie, YANG Quan, YANG Xianwen. Sepration and antitumor activities of secondary metabolites from marine actinomycete Nocardiopsis sp. SCSIO 11492[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 406-410. doi: 10.3969/j.issn.1006-0111.2015.05.006
Citation: SU Ruiqiang, LI Yan, PENG Kun, LI Jie, YANG Quan, YANG Xianwen. Sepration and antitumor activities of secondary metabolites from marine actinomycete Nocardiopsis sp. SCSIO 11492[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 406-410. doi: 10.3969/j.issn.1006-0111.2015.05.006
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