WU Sifan, TAN Changyu, FAN Hongbin, YIN Xiaoxing, LU Qian. A Meta-analysis for the evaluation of efficacy and safety of oxcarbazepine and carbamazepine for post-stroke epilepsy[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 373-378. doi: 10.3969/j.issn.1006-0111.2018.04.020
Citation:
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ZHANG Yanqing, CHEN Jinshan, LI Jinyu, LIN Xiuli, SHI Hekun, LIN Xiaofeng. Influence of multidrug resistant gene polymorphisms and haplotype on blood concentration of tacrolimus in individuals in stable phases after renal transplantation[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 415-418. doi: 10.3969/j.issn.1006-0111.2015.05.008
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Influence of multidrug resistant gene polymorphisms and haplotype on blood concentration of tacrolimus in individuals in stable phases after renal transplantation
- 1.
No.175 Hospital of PLA, Department of Pharmacy, Zhangzhou 363000, China
- 2.
No.175 Hospital of PLA, Department of Urology, Zhangzhou 363000, China
- Received Date: 2015-03-09
- Rev Recd Date:
2015-07-06
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Abstract
Objective To study the relevance between the polymorphisms and haplotype of multidrug resistant gene (MDR1) and the ratio of blood concentration/dosage in individuals treated by tacrolimus in stable phases post renal transplantation, and to provide data for personalized FK-506 administration. Methods The MDR1 C1236T, G2677T/A and C3435T genotypes of 104 renal transplantation patients were determined by PCR followed sequencing method. The blood concentration of tacrolimus was detected by EMIT method. The differences in concentration/ (dose×weight) (C/D) ratios were compared among all of the genotype groups treated by tacrolimus. Results In the 104 renal transplantation recipients, the frequency of MDR1 C1236T,G2677T/A and C3435T mutation alleles was 56.73%, 55.77% and 33.17%, respectively. A correlation was revealed among SNP of MDR1 C3435T, TTT haplotype and the C/D ratios (P<0.05). In patients of CYP3A5*3*3, A correlation was also found among TTT haplotype and the C/D ratios (P<0.05). No difference was found among the MDR1 C1236T, G2677T/A, CGC haplotype and the C/D ratios (P>0.05). Conclusion It is demonstrated that genetic polymorphisms of MDR1 C3435T and TTT haplotype are correlated with C/D ratio of tacrolimus in Chinese renal transplant patients in stable stage. These findings affect the dose-adjusted concentration of tacrolimus individually.
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