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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(5): 445-447

ZHOU Qian, LIU Kui, MA Jing, TAN Guangguo. Protective effect of Qifu decoction on adriamycin-induced cardiac injury based on GC-MS serum metabolomics[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 313-317. doi: 10.3969/j.issn.1006-0111.2018.04.006
Citation: ZHANG Minxin, HUANG Aiwen, SONG Hongtao. Simultaneous determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in Maxing oral solution by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 445-447. doi: 10.3969/j.issn.1006-0111.2015.05.017
shu

Simultaneous determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in Maxing oral solution by HPLC

doi: 10.3969/j.issn.1006-0111.2015.05.017

  • Department of Pharmacy, Fuzhou General Hospital of Nanjing Command, PLA, Fuzhou 350025, China

  • Received Date: 2014-10-13
  • Rev Recd Date: 2015-01-13
  • Objective To establish an HPLC method for determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in Maxing oral solution. Methods Phenomenex Hydro-RP (250 mm×4.6 mm, 4 μm) was adopted. Acetonitnile (A) and 0.1% phosphonic acid solution (0.1% triethanolamine solution)(B) was used as gradient mobile phase(0-20 min, 3%→10% A)at flow rate was 1.0 ml/min and the program of UV gradient absorbance detection was 210 nm. The sample volume was 20 μl. Results A good linearity was obtained over the concentration range of 0.99-39.6 μg/ml for ephedrine hydrochloride (r=0.999 9) and 1.09-43.6 μg/ml for pseudoephedrine hydrochloride (r=0.999 9). The average recovery of ephedrine hydrochloride was 101.5% with RSD of 1.77% (n=6), and the average recovery of pseudoephedrine hydrochloride was 100.8% with RSD of 1.96% (n=6). Conclusion This method was simple,accurate and quick,which could be used for determination and quality control of Maxing oral solution with good selectivity and repeatability.
  • [1] 中国人民解放军总后勤部. 中国人民解放军医疗机构制剂规范[S]. 北京:人民军医出版社,2002:35-36.
    [2] 李 翔,刘皈阳.HPLC法测定麻杏口服液中苦杏林苷的含量[J].解放军药学学报,2013,29(1):57-59.
    [3] 边向阳,江希连.高效液相色谱法测定麻杏口服液中绿原酸和黄芩苷的含量[J].海峡药学,2010,22(5):75-76.
    [4] 国家药典委员会.中华人民共和国药典2010年版一部[S]. 北京:中国医药科技出版社,2010: 495-496,300-301.
    [5] 王泽民.当代结构药物全集[M].北京:北京科学技术出版社,1993:1620-1621.
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    2. 米彦飞，侯丽丽，武晋孝，郭禹. 高效液相色谱法测定麻杏石甘颗粒中盐酸麻黄碱含量. 中国兽药杂志. 2020(03): 26-31 .
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Simultaneous determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in Maxing oral solution by HPLC

doi: 10.3969/j.issn.1006-0111.2015.05.017
  • Department of Pharmacy, Fuzhou General Hospital of Nanjing Command, PLA, Fuzhou 350025, China
  • Received Date: 2014-10-13
  • Rev Recd Date: 2015-01-13

Abstract: Objective To establish an HPLC method for determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in Maxing oral solution. Methods Phenomenex Hydro-RP (250 mm×4.6 mm, 4 μm) was adopted. Acetonitnile (A) and 0.1% phosphonic acid solution (0.1% triethanolamine solution)(B) was used as gradient mobile phase(0-20 min, 3%→10% A)at flow rate was 1.0 ml/min and the program of UV gradient absorbance detection was 210 nm. The sample volume was 20 μl. Results A good linearity was obtained over the concentration range of 0.99-39.6 μg/ml for ephedrine hydrochloride (r=0.999 9) and 1.09-43.6 μg/ml for pseudoephedrine hydrochloride (r=0.999 9). The average recovery of ephedrine hydrochloride was 101.5% with RSD of 1.77% (n=6), and the average recovery of pseudoephedrine hydrochloride was 100.8% with RSD of 1.96% (n=6). Conclusion This method was simple,accurate and quick,which could be used for determination and quality control of Maxing oral solution with good selectivity and repeatability.

ZHOU Qian, LIU Kui, MA Jing, TAN Guangguo. Protective effect of Qifu decoction on adriamycin-induced cardiac injury based on GC-MS serum metabolomics[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 313-317. doi: 10.3969/j.issn.1006-0111.2018.04.006
Citation: ZHANG Minxin, HUANG Aiwen, SONG Hongtao. Simultaneous determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in Maxing oral solution by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 445-447. doi: 10.3969/j.issn.1006-0111.2015.05.017
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