WU Yamiao, JIANG Xiunong. Effect of S-adenosylmethionine (SAM) on the treatment of chronic hepatitis B with hyperbilirubinemia[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 457-459. doi: 10.3969/j.issn.1006-0111.2015.05.021
| Citation:
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WU Yamiao, JIANG Xiunong. Effect of S-adenosylmethionine (SAM) on the treatment of chronic hepatitis B with hyperbilirubinemia[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 457-459. doi: 10.3969/j.issn.1006-0111.2015.05.021
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Effect of S-adenosylmethionine (SAM) on the treatment of chronic hepatitis B with hyperbilirubinemia
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Ningbo Second Hospital, Department of Pharmacy;
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Ningbo Second Hospital, No.4 Department of Hepatitis, Ningbo 315010, China
- Received Date: 2014-05-06
- Rev Recd Date:
2015-03-10
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Abstract
Objective To evaluate the clinical efficiencies and safeties of S-adenosylmethionine (SAM) in treatment of 34 patients with chronic hepatitis B complicated hyperbilirubinemia. Methods Patients which meet the diagnostic criteria were randomized into the group with treatment of SAM (the treatment group, 34 cases) and the group with Kuhuang injection (the contrast group, 35 cases), 4 weeks for a course of treatment. The clinical efficacies and safeties were observed in the two groups. Results Compared with the contrast group, the overall efficiency was better in the treatment group (91.2% vs 68.6%, P<0.05), and the curative effects of serum ALT,serum bilirubin,TBA levels were better in the treatment group after treatment (P<0.01). There were no adverse drug reactions in the treatment group and 3 cases with adverse drug reactions in the contrast group. Conclusion The clinical efficiencies and safeties of SAM treatment in patients with chronic hepatitis B complicated hyperbilirubinemia were better than that of Kuhuang injection.
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