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ZHANG Yuanlin, SONG Kai, SUN Rui, SHU Fei, SHU Lixin, YANG Zhangwei. Review of drug utilization research based on real-world data[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(6): 238-243. doi: 10.12206/j.issn.2097-2024.202312010
Citation:
WU Jianjun, BAO Yingfei, ZHAO Yang, CAI Heping, YANG Zhangwei, ZHOU Jia, WANG Xuebin, CHEN Cuimin. The correlation between the resistance rate of Acinetobacter baumannii and antimicrobial consumption[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 467-470. doi: 10.3969/j.issn.1006-0111.2015.05.024
The correlation between the resistance rate of Acinetobacter baumannii and antimicrobial consumption
Department of Pharmacy, General Hospital of Tibet Military Region, Lhasa 850007, China
2.
Department of Pharmacy, Changhai Hospital Affialated to Second Military Medical University, Shanghai 200433, China
3.
State Food and Drug Administration Institute of Executive Development, Beijing 100073, China
Received Date: 2013-11-06
Rev Recd Date:
2015-06-23
Abstract
Objective To analyze the relevance between the consumption of various antimicrobials and antimicrobial resistance of Acinetobacter baumanni in a grade three hospital during 2007-2010. Methods A retrospective analysis was performed to count and sort the defined daily doses (DDDs) and the consumption of various antimicrobials in the hospital between 2007 and 2010. Meanwhile the resistance rates of Acinetobacter baumanni to different antimicrobials were collected in the same period. Data was analyzed by SAS 8.2 statistical software package using Spearman correlation method. Results The resistance rate of Acinetobacter baumanni to imipenem was significantly positively correlated with the consumption of carbapenems (r=0.954 6, P<0.01), it is positively correlated with the dosage of imipenem (r=0.849 2,P<0.05), it is also significantly positively correlated with the consumption of meropenem (r=0.999 2,P<0.05),and the consumption of amoxicillin/clavulanate potassium, respectively(r=0.800 5,P<0.05). There was no correlation between the resistance rate of Acinetobacter baumanni and the dosage of aminoglycosides, fluoroquinolones, even β-lactamase inhibitors(P>0.05). Conclusion The use of carbapenems should be correlated with their indications strictly, only applying to severe infection of Acinetobacter baumanni. The aminoglycosides of amikacin and β-lactamase inhibitors of cefoperazone/sulbactam are the better options to treat Acinetobacter baumanni infection.
Jiang M, Zhang Z, Zhao S. Epidemiological characteristics and drug resistance analysis of multidrug-resistant Acinetobacter baumannii in a China hospital at a certain time[J]. Pol J Microbiol, 2014,63(3):275-281.
[2]
Muraki Y,Kitamura M,Maeda Y,et al.Nationwide surveillance of antimicrobial consumption and resistance to Pseudomonas aeruginosa isolates at 203 Japanese hospitals in 2010 [J].Infection,2013,41(2):415-423.
Bou G,Cervero G,Dominguez MA,et al.Characterization of a nosocomial outbreak caused by a multiresisrant Acinetobacter baumannii strain with a carbapenemhydrolyzing enzyme:high-level carbapenem resistance in A.baumannii is not due solely to the presence of β-lactamases[J].J Clin Microbiol,2000,38:3299-3305.
Abstract: Objective To analyze the relevance between the consumption of various antimicrobials and antimicrobial resistance of Acinetobacter baumanni in a grade three hospital during 2007-2010. Methods A retrospective analysis was performed to count and sort the defined daily doses (DDDs) and the consumption of various antimicrobials in the hospital between 2007 and 2010. Meanwhile the resistance rates of Acinetobacter baumanni to different antimicrobials were collected in the same period. Data was analyzed by SAS 8.2 statistical software package using Spearman correlation method. Results The resistance rate of Acinetobacter baumanni to imipenem was significantly positively correlated with the consumption of carbapenems (r=0.954 6, P<0.01), it is positively correlated with the dosage of imipenem (r=0.849 2,P<0.05), it is also significantly positively correlated with the consumption of meropenem (r=0.999 2,P<0.05),and the consumption of amoxicillin/clavulanate potassium, respectively(r=0.800 5,P<0.05). There was no correlation between the resistance rate of Acinetobacter baumanni and the dosage of aminoglycosides, fluoroquinolones, even β-lactamase inhibitors(P>0.05). Conclusion The use of carbapenems should be correlated with their indications strictly, only applying to severe infection of Acinetobacter baumanni. The aminoglycosides of amikacin and β-lactamase inhibitors of cefoperazone/sulbactam are the better options to treat Acinetobacter baumanni infection.
ZHANG Yuanlin, SONG Kai, SUN Rui, SHU Fei, SHU Lixin, YANG Zhangwei. Review of drug utilization research based on real-world data[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(6): 238-243. doi: 10.12206/j.issn.2097-2024.202312010
Citation:
WU Jianjun, BAO Yingfei, ZHAO Yang, CAI Heping, YANG Zhangwei, ZHOU Jia, WANG Xuebin, CHEN Cuimin. The correlation between the resistance rate of Acinetobacter baumannii and antimicrobial consumption[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 467-470. doi: 10.3969/j.issn.1006-0111.2015.05.024
Jiang M, Zhang Z, Zhao S. Epidemiological characteristics and drug resistance analysis of multidrug-resistant Acinetobacter baumannii in a China hospital at a certain time[J]. Pol J Microbiol, 2014,63(3):275-281.
[2]
Muraki Y,Kitamura M,Maeda Y,et al.Nationwide surveillance of antimicrobial consumption and resistance to Pseudomonas aeruginosa isolates at 203 Japanese hospitals in 2010 [J].Infection,2013,41(2):415-423.
Bou G,Cervero G,Dominguez MA,et al.Characterization of a nosocomial outbreak caused by a multiresisrant Acinetobacter baumannii strain with a carbapenemhydrolyzing enzyme:high-level carbapenem resistance in A.baumannii is not due solely to the presence of β-lactamases[J].J Clin Microbiol,2000,38:3299-3305.
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ZHANG Yuanlin, SONG Kai, SUN Rui, SHU Fei, SHU Lixin, YANG Zhangwei. Review of drug utilization research based on real-world data[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(6): 238-243. doi: 10.12206/j.issn.2097-2024.202312010
ZHANG Yuanlin, SONG Kai, SUN Rui, SHU Fei, SHU Lixin, YANG Zhangwei. Review of drug utilization research based on real-world data[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(6): 238-243. doi: 10.12206/j.issn.2097-2024.202312010
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