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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(3): 237-240,248

JIA Yuting, JIN Yuchen, TAN Guangguo. Study on Sini decoction in treatment of hypothyroidism by metabonomic method[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 237-240,248. doi: 10.3969/j.issn.1006-0111.2016.03.011
Citation: JIA Yuting, JIN Yuchen, TAN Guangguo. Study on Sini decoction in treatment of hypothyroidism by metabonomic method[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 237-240,248. doi: 10.3969/j.issn.1006-0111.2016.03.011
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Study on Sini decoction in treatment of hypothyroidism by metabonomic method

doi: 10.3969/j.issn.1006-0111.2016.03.011
  • 1.

    Fourth Military Medical University, First Cadets Brigade, Xi'an 710032, China

  • 2.

    Fourth Military Medical University, Department of Pharmaceutical Analysis, School of Pharmacy, Xi'an 710032, China

  • Received Date: 2016-03-14
  • Rev Recd Date: 2016-04-22
  • Objective To evaluate therapeutic effects of Sini decoction (SND) on hypothyroidism based on serum metabonomics method. Methods Twenty-four rats were randomly divided into three groups including sham group, surgery-induced hypothyroid model group and SND-treated group. The SND-treated group was given SND for 4 weeks. After 4 weeks, the serum samples of each rat were collected and analyzed by UHPLC-Q-TOFMS, pattern recognition analysis of metabolomics differences among the groups and therapeutic effects of SND were evaluated. Results Total of 9 metabolites were identified through serum metabonomics analysis. It was showed that there was a possible mechanism that hypothyroidism was mainly involved in citrate cycle, phenylalanine metabolism, sphingolipid metabolism and phospholipid metabolism and the damage of hypothyroidism was reversed by SND. Conclusion SND administration could provide satisfactory effects on hypothyroidism through partially regulating the perturbed citrate cycle, phenylalanine metabolism and phospholipid metabolism.
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    [2] Flynn RW, Bonellie SR, Jung RT, et al. Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapy[J]. J Clin Endocrinol Metab, 2010,95(1):186-193.
    [3] La Vignera S, Vicari E, Tumino S, et al. L-thyroxin treatment and post-menopausal osteoporosis:relevance of the risk profile present in clinical history[J]. Minerva Ginecol, 2008,60(6):475-484.
    [4] 蔡定芳, 陈晓红, 刘彦芳, 等. 探讨阴中求阳与阳中求阴对谷氨酸单钠大鼠下丘脑-垂体-肾上腺-胸腺轴的影响[J]. 中国中西医结合杂志,1999,19(7):415-417.
    [5] Tan G, Zhu Z, Jing J, et al. Characterization of constituents in Sini decoction and rat plasma by high-performance liquid chromatography with diode array detection coupled to time-of-flight mass spectrometry[J]. Biomed Chromatogr, 2011, 25(8):913-924.
    [6] Guo L, Tan G, Liu P, et al. Three plasma metabolite signatures for diagnosing high altitude pulmonary edema[J]. Sci Rep, 2015, 5:15126.
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    [8] Wu S, Tan G, Dong X, et al. Metabolic profiling provides a system understanding of hypothyroidism in rats and its application[J]. PLoS One, 2013, 8(2):e55599.
    [9] 国家药典委员会. 中华人民共和国药典2015年版一部[S].北京:中国医药科技出版社,2015:789.
    [10] Alzoubi KH, Gerges NZ, Aleisa AM, et al. Levothyroxin restores hypothyroidism-induced impairment of hippocampus-dependent learning and memory:Behavioral, electrophysiological, and molecular studies[J]. Hippocampus, 2009, 19(1):66-78.
    [11] Tan G, Lou Z, Liao W, et al. Hydrophilic interaction and reversed-phase ultraperformance liquid chromatography TOF-MS for serum metabonomic analysis of myocardial infarction in rats and its applications[J]. Mol Biosyst, 2012, 8(2):548-556.
    [12] Briere JJ, Favier J, Gimenez-Roqueplo AP, et al. Tricarboxylic acid cycle dysfunction as a cause of human diseases and tumor formation[J]. Am J Physiol Cell Physiol, 2006, 291(6):C1114-C1120.
    [13] Sjoberg S, Eriksson M, Nordin C. L-thyroxine treatment and neurotransmitter levels in the cerebrospinal fluid of hypothyroid patients:a pilot study[J]. Eur J Endocrinol, 1998, 139(5):493-497.
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Study on Sini decoction in treatment of hypothyroidism by metabonomic method

doi: 10.3969/j.issn.1006-0111.2016.03.011
  • 1. Fourth Military Medical University, First Cadets Brigade, Xi'an 710032, China
  • 2. Fourth Military Medical University, Department of Pharmaceutical Analysis, School of Pharmacy, Xi'an 710032, China
  • Received Date: 2016-03-14
  • Rev Recd Date: 2016-04-22

Abstract: Objective To evaluate therapeutic effects of Sini decoction (SND) on hypothyroidism based on serum metabonomics method. Methods Twenty-four rats were randomly divided into three groups including sham group, surgery-induced hypothyroid model group and SND-treated group. The SND-treated group was given SND for 4 weeks. After 4 weeks, the serum samples of each rat were collected and analyzed by UHPLC-Q-TOFMS, pattern recognition analysis of metabolomics differences among the groups and therapeutic effects of SND were evaluated. Results Total of 9 metabolites were identified through serum metabonomics analysis. It was showed that there was a possible mechanism that hypothyroidism was mainly involved in citrate cycle, phenylalanine metabolism, sphingolipid metabolism and phospholipid metabolism and the damage of hypothyroidism was reversed by SND. Conclusion SND administration could provide satisfactory effects on hypothyroidism through partially regulating the perturbed citrate cycle, phenylalanine metabolism and phospholipid metabolism.

JIA Yuting, JIN Yuchen, TAN Guangguo. Study on Sini decoction in treatment of hypothyroidism by metabonomic method[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 237-240,248. doi: 10.3969/j.issn.1006-0111.2016.03.011
Citation: JIA Yuting, JIN Yuchen, TAN Guangguo. Study on Sini decoction in treatment of hypothyroidism by metabonomic method[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 237-240,248. doi: 10.3969/j.issn.1006-0111.2016.03.011
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