WANG Yang, ZHAI Xin, HAN Liya, ZHANG Hong, ZHENG Chengjian, QIN Luping. Effects of eleutheroside E on learning and memory ability in mice[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 318-319,371. doi: 10.3969/j.issn.1006-0111.2016.04.008
| Citation:
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WANG Yang, ZHAI Xin, HAN Liya, ZHANG Hong, ZHENG Chengjian, QIN Luping. Effects of eleutheroside E on learning and memory ability in mice[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 318-319,371. doi: 10.3969/j.issn.1006-0111.2016.04.008
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Effects of eleutheroside E on learning and memory ability in mice
- 1.
Zhejiang Int Medicinal Pharmaceutical Co., Ltd., Hangzhou 310000, China;Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- 2.
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- Received Date: 2016-01-04
- Rev Recd Date:
2016-05-23
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Abstract
Objective To study the influence of eleutheroside E(ELE)on the learning and memory abilities of mice induced by para-chlorophenylalanine (PCPA) and on hippocampus' monoamine neurotransmitters of serotonin(5-HT),5-hydroxindole acetic acid (5-HIAA), dopamine (DA) and norepinephrine (NA). Methods Balb/c mice were randomized into control group, model group, positive group and three treatment groups (high, moderate and low dose group). The mouse injury model was established by PCPA abdominal injection. The mice's abilities of learning and memory were detected in the Morris water maze test after 14 days of prevention medicine. The contents of 5-HT, 5-HIAA, DA and NA in mice's hippocampus were detected by Elisa kit. Results The behavior results showed that, compared with control group, the times across the platform by model group decreased significantly (P<0.01). The times across the platform by high and moderate dose groups increased significantly (P<0.01) after the administration of ELE. The contents of 5-HT and 5-HIAA of the model group were lower than those of the control group (P<0.01). The contents of NA was lower too (P<0.05). The contents of 5-HT and 5-HIAA of different dose groups were much higher than those of the model group. Conclusion The enhancement of learning and memory ability in the mouse injury model established by PCPA might be related with the improvement of the contents of 5-HT, 5-HIAA, DA, NA in mice's hippocampus by ELE.
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