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Volume 34 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(4): 330-333

WANG Kexing, QIN Cuiying, HAN Jing, LI Rongli, CHEN Rencai. The preparation of self-microemulsifying dropping pills of paclitaxel and its drug release in vitro[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 330-333. doi: 10.3969/j.issn.1006-0111.2016.04.012
Citation: WANG Kexing, QIN Cuiying, HAN Jing, LI Rongli, CHEN Rencai. The preparation of self-microemulsifying dropping pills of paclitaxel and its drug release in vitro[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 330-333. doi: 10.3969/j.issn.1006-0111.2016.04.012
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The preparation of self-microemulsifying dropping pills of paclitaxel and its drug release in vitro

doi: 10.3969/j.issn.1006-0111.2016.04.012

  • Shenyang Pharmaceutical University, Shenyang 110016, China

  • Received Date: 2015-08-27
  • Rev Recd Date: 2016-01-08
  • Objective The research is about optimization of preparation procedure of self-microemulsifying dropping pills of paclitaxel (PTX-SM-DP). The drug release in vitro of PTX-SM-DP was investigated. Methods The ratio of SMEDDS and bases, dropping distance, temperature and speed of dripping were investigated by using the orthogonal test. The weight difference of dropping pill, hardness and roundness were evaluated to optimize the preparation conditions of PTX-SM-DP. Dissolution of vitro was determined. Results The optimal preparation conditions were as follows:the ratio of SMEDDS and bases was 1:3, dropping distance was 15 cm, temperature of dripping preparation was 80℃ and dripping speed was 30 drops/min. Conclusion The optimized technical condition is stable and feasible. PTX-SM-DP can improve paclitaxel dissolution.
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    [4] 周丽娟, 陈曦, 刘清飞, 等. 紫杉醇自微乳释药体系的处方工艺及稳定性研究[J]. 医药导报, 2014, 33(8):1063-1067.
    [5] Malingré MM, Beijnen JH, Schellens JH. Oral delivery of taxanes[J]. Invest New Drugs, 2001, 19(2):155-162.
    [6] Gursoy RN, Benita S. Self-emulsifying drug delivery systems(SEDDS)for improved oral delivery of lipophilic drugs[J].Biomed Pharmacother, 2004, 58(3):173-182.
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    [8] 赵佳丽, 温许, 张晶, 等. 口服固体自微乳化给药系统的研究进展[J]. 药学实践杂志, 2014, 32(4):257-260.
    [9] 姚依婧, 郭秉玉, 韩静, 等.星点设计-效应面法优化紫杉醇自微乳给药系统[J]. 中南药学, 2014, 12(5):1069-1072.
    [10] 宋凤兰, 潘育方, 侯冬枝, 等. 葛根总黄酮滴丸的制备与溶出度研究[J]. 中草药, 2014, 45(9):1252-1256.
    [11] Wang B. Orthogonal test design for optimisation of extraction of trans-resveratrol from Pinot Noir-grape pomace[J]. Nat Prod Res, 2012, 26(9):821-829.
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The preparation of self-microemulsifying dropping pills of paclitaxel and its drug release in vitro

doi: 10.3969/j.issn.1006-0111.2016.04.012
  • Shenyang Pharmaceutical University, Shenyang 110016, China
  • Received Date: 2015-08-27
  • Rev Recd Date: 2016-01-08

Abstract: Objective The research is about optimization of preparation procedure of self-microemulsifying dropping pills of paclitaxel (PTX-SM-DP). The drug release in vitro of PTX-SM-DP was investigated. Methods The ratio of SMEDDS and bases, dropping distance, temperature and speed of dripping were investigated by using the orthogonal test. The weight difference of dropping pill, hardness and roundness were evaluated to optimize the preparation conditions of PTX-SM-DP. Dissolution of vitro was determined. Results The optimal preparation conditions were as follows:the ratio of SMEDDS and bases was 1:3, dropping distance was 15 cm, temperature of dripping preparation was 80℃ and dripping speed was 30 drops/min. Conclusion The optimized technical condition is stable and feasible. PTX-SM-DP can improve paclitaxel dissolution.

WANG Kexing, QIN Cuiying, HAN Jing, LI Rongli, CHEN Rencai. The preparation of self-microemulsifying dropping pills of paclitaxel and its drug release in vitro[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 330-333. doi: 10.3969/j.issn.1006-0111.2016.04.012
Citation: WANG Kexing, QIN Cuiying, HAN Jing, LI Rongli, CHEN Rencai. The preparation of self-microemulsifying dropping pills of paclitaxel and its drug release in vitro[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 330-333. doi: 10.3969/j.issn.1006-0111.2016.04.012
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