Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 34 Issue 4
. 
Turn off MathJax
Article Contents
Abstract
References
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(4): 348-350,356

TAN Ning, LI Pengyue, DONG Boyu, ZHAO Mengdi, YANG Liu, LU Yang. Study on the rat pulmonary irritation of aerosol inhaled Tanreqing and Reduning[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 348-350,356. doi: 10.3969/j.issn.1006-0111.2016.04.016
Citation: TAN Ning, LI Pengyue, DONG Boyu, ZHAO Mengdi, YANG Liu, LU Yang. Study on the rat pulmonary irritation of aerosol inhaled Tanreqing and Reduning[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 348-350,356. doi: 10.3969/j.issn.1006-0111.2016.04.016
shu

Study on the rat pulmonary irritation of aerosol inhaled Tanreqing and Reduning

doi: 10.3969/j.issn.1006-0111.2016.04.016

  • School of Chinese material medica, Beijing University of Chinese Medicine, Beijing 100029, China

  • Received Date: 2015-08-22
  • Rev Recd Date: 2016-01-03
  • Objective To study the rat pulmonary irritant of aerosol inhaled Tanreqing and Reduning injection. Methods Rats were devided into two groups for each medicine (low concentration group and high concentration group), nebulized drug administration for seven days, with the control group irrigated with saline, and were sacrificed. Through bronchoalveolar lavage, excurrent bronchoalveolar lavage fluid (BALF) was used for total protein determination and LDH vitality test to evaluate pulmonary toxicity of two medicines. Results The protein concentrations of two groups in low and high concentrations of Tanreqing and Reduning respectively are (193.78±27.74),(235.33±50.41) μg/ml;(174.02±17.82),(227.27±66.03) μg/ml;LDH vitalities respectively are 1065.21±181.76,1467.33±101.87;307.97±47.56,1377.29±566.48. By t-test, compared with normal saline, there was no significant effect among these five groups on protein concentration, but these two medicine were able to improve LDH activity (P<0.05) which was more obvious in high concentration group. When two medicines were in low concentration, LDH activity was higher in Tanreqing group with statistical significance (P<0.05). Conclusion Aerosol inhaled Tanreqing and Reduning injection in rats have some pulmonary irritation and potential safety hazard in this delivery way.
  • [1] 凌 祥,沈 雁,孙春萌,等.肺部给药研究近况[J].药学研究,2014,33(12):711-714.
    [2] 王 淳,刘晓彬,权丽辉,等.中药肺部给药系统应用进展[J].世界科学技术:中医药现代化,2007,9(1):59-64.
    [3] 雷卫平,吴英梅,林翠芬.痰热清注射液的临床应用[J].国际医药卫生导报,2005,11(14):110-113.
    [4] 张 妍,杨毅恒,刘 芳,等.痰热清注射液雾化吸入治疗呼吸系统疾病的系统评价[J].中国医院用药评价与分析,2010,10(6):483-487.
    [5] 唐 韵.喜炎平注射液临床应用近况[J].世界临床药物,2014,35(3):184-188.
    [6] 万 珍,徐志锋,林俊明,等.喜炎平超声雾化吸入治疗成人急性上呼吸道感染疗效观察[J].新中医,2014,46(6):57-59.
    [7] 张华静,郑德瑜.喜炎平注射液联合利巴韦林雾化吸入治疗小儿疱疹性咽峡炎观察[J].中医药临床杂志,2014,26(12):1247-1248.
    [8] 王 晶,任吉祥,谢雁鸣,等.喜炎平注射液治疗手足口病的系统评价[J].中国中药杂志,2013,38(18):3215-3222.
    [9] 耿 红,吴明杰.喜炎平雾化吸入后拍背吸痰佐治小儿毛细支气管炎的临床观察[J].临床合理用药杂志,2012,5(6B):70
  • Created with Highcharts 5.0.7Amount of accessChart context menuAbstract Views, HTML Views, PDF Downloads StatisticsAbstract ViewsHTML ViewsPDF Downloads2024-052024-062024-072024-082024-092024-102024-112024-122025-012025-022025-032025-040Highcharts.com
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 84.5 %FULLTEXT: 84.5 %META: 14.1 %META: 14.1 %PDF: 1.3 %PDF: 1.3 %FULLTEXTMETAPDFHighcharts.com
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 21.5 %其他: 21.5 %China: 1.3 %China: 1.3 %Korea Republic of: 0.2 %Korea Republic of: 0.2 %United States: 0.2 %United States: 0.2 %[]: 0.2 %[]: 0.2 %上海: 2.0 %上海: 2.0 %中山: 0.2 %中山: 0.2 %北京: 19.3 %北京: 19.3 %南京: 0.4 %南京: 0.4 %南通: 0.2 %南通: 0.2 %呼和浩特: 0.2 %呼和浩特: 0.2 %哈尔滨: 0.4 %哈尔滨: 0.4 %商丘: 0.2 %商丘: 0.2 %安阳: 0.2 %安阳: 0.2 %安顺: 0.2 %安顺: 0.2 %宝鸡: 0.2 %宝鸡: 0.2 %宿迁: 0.2 %宿迁: 0.2 %张家口: 0.4 %张家口: 0.4 %成都: 1.3 %成都: 1.3 %杭州: 1.3 %杭州: 1.3 %武汉: 0.2 %武汉: 0.2 %海口: 0.2 %海口: 0.2 %甘孜: 0.2 %甘孜: 0.2 %盐城: 0.9 %盐城: 0.9 %石家庄: 0.2 %石家庄: 0.2 %秦皇岛: 0.4 %秦皇岛: 0.4 %芒廷维尤: 18.2 %芒廷维尤: 18.2 %西宁: 26.0 %西宁: 26.0 %西安: 0.2 %西安: 0.2 %运城: 0.4 %运城: 0.4 %长沙: 0.2 %长沙: 0.2 %长治: 0.2 %长治: 0.2 %阳泉: 0.2 %阳泉: 0.2 %青岛: 0.2 %青岛: 0.2 %黄冈: 0.9 %黄冈: 0.9 %龙岩: 0.4 %龙岩: 0.4 %其他ChinaKorea Republic ofUnited States[]上海中山北京南京南通呼和浩特哈尔滨商丘安阳安顺宝鸡宿迁张家口成都杭州武汉海口甘孜盐城石家庄秦皇岛芒廷维尤西宁西安运城长沙长治阳泉青岛黄冈龙岩Highcharts.com

  • Cited by

    Periodical cited type(8)

    1. 田珩，杨仪雪，吴纯敏，严全鸿. 喉宁雾化吸入溶液的雾化特性分析. 中国药学杂志. 2024(15): 1416-1423 .
    2. 刘秀丽，王安娜，刘博，陈世超，韩冬. 喜炎平注射液雾化吸入对小鼠祛痰抗炎作用研究. 吉林中医药. 2022(02): 213-215 .
    3. 石建美，吕佳康，韩玲. 供雾化器用液体制剂中药新药研发的思考. 中国药理学与毒理学杂志. 2021(01): 14-17 .
    4. 袁兴东，徐瑾，刘志军，张薇，周鹃，徐玉茗. 喜炎平注射液临床应用及安全性研究进展. 海峡药学. 2020(10): 28-31 .
    5. 张广平，高云航，苏萍，侯红平，叶祖光. 经肺吸入用中药液体制剂的研发及其应用前景展望. 中国现代中药. 2019(12): 1732-1738 .
    6. 傅淑琼. 肺癌患者肺叶切除术围手术期雾化吸入痰热清的效果观察. 西南国防医药. 2018(06): 547-550 .
    7. 刘静. 喜炎平注射液在感染性疾病中的应用. 内蒙古中医药. 2017(12): 145-146 .
    8. 赵宜乐，董鹏欣，郑丽英，韩晟. 喜炎平注射液的循证安全性评估. 药品评价. 2017(11): 5-11+61 .

    Other cited types(4)

通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(3324) PDF downloads(598) Cited by(12)

Related
Proportional views

Study on the rat pulmonary irritation of aerosol inhaled Tanreqing and Reduning

doi: 10.3969/j.issn.1006-0111.2016.04.016
  • School of Chinese material medica, Beijing University of Chinese Medicine, Beijing 100029, China
  • Received Date: 2015-08-22
  • Rev Recd Date: 2016-01-03

Abstract: Objective To study the rat pulmonary irritant of aerosol inhaled Tanreqing and Reduning injection. Methods Rats were devided into two groups for each medicine (low concentration group and high concentration group), nebulized drug administration for seven days, with the control group irrigated with saline, and were sacrificed. Through bronchoalveolar lavage, excurrent bronchoalveolar lavage fluid (BALF) was used for total protein determination and LDH vitality test to evaluate pulmonary toxicity of two medicines. Results The protein concentrations of two groups in low and high concentrations of Tanreqing and Reduning respectively are (193.78±27.74),(235.33±50.41) μg/ml;(174.02±17.82),(227.27±66.03) μg/ml;LDH vitalities respectively are 1065.21±181.76,1467.33±101.87;307.97±47.56,1377.29±566.48. By t-test, compared with normal saline, there was no significant effect among these five groups on protein concentration, but these two medicine were able to improve LDH activity (P<0.05) which was more obvious in high concentration group. When two medicines were in low concentration, LDH activity was higher in Tanreqing group with statistical significance (P<0.05). Conclusion Aerosol inhaled Tanreqing and Reduning injection in rats have some pulmonary irritation and potential safety hazard in this delivery way.

TAN Ning, LI Pengyue, DONG Boyu, ZHAO Mengdi, YANG Liu, LU Yang. Study on the rat pulmonary irritation of aerosol inhaled Tanreqing and Reduning[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 348-350,356. doi: 10.3969/j.issn.1006-0111.2016.04.016
Citation: TAN Ning, LI Pengyue, DONG Boyu, ZHAO Mengdi, YANG Liu, LU Yang. Study on the rat pulmonary irritation of aerosol inhaled Tanreqing and Reduning[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 348-350,356. doi: 10.3969/j.issn.1006-0111.2016.04.016
shu

    HTML

Reference (9)

Catalog

  • HTML

版权所有：《药学实践与服务》编辑委员会

Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

网站备案号 沪ICP备05003363号-1

Supported by: Beijing Renhe Information Technology Co., Ltd.  

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return