Predicting expiration date of torasemide injection by classical constant-temperature experiment

ZHANG Yanqin; XU Xiaohong

doi:10.3969/j.issn.1006-0111.2016.04.019

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Volume 34 Issue 4

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2016 > 34(4): 357-358,384

ZHANG Yanqin, XU Xiaohong. Predicting expiration date of torasemide injection by classical constant-temperature experiment[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 357-358,384. doi: 10.3969/j.issn.1006-0111.2016.04.019

Citation:

ZHANG Yanqin, XU Xiaohong. Predicting expiration date of torasemide injection by classical constant-temperature experiment[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 357-358,384. doi: 10.3969/j.issn.1006-0111.2016.04.019

Predicting expiration date of torasemide injection by classical constant-temperature experiment

doi: 10.3969/j.issn.1006-0111.2016.04.019

ZHANG Yanqin¹,
XU Xiaohong²

1.
Xi'an Medicine Supply Station, Lanzhou Military Region, Xi'an 710043, China,
2.
Chengdu Medical College, Chengdu, 610500, China

Received Date: 2015-10-13
Rev Recd Date: 2016-04-12

Abstract

Objective To investigate the stability of torasemide injection and predict its expiration date in room temperatue. Methods The contents of torasemide were determined by HPLC. The expiration date was predicted by classical constant-temperature experiment. Results The contents of torasemide degradation with time according to a first order reaction at room temperature (25℃). The disintegration rate constant K was K25℃=5.1869×10^-6 h^-1 and the expiration date of torasemide injection was t_0.9=2.32 years. Conclusion The torasemide injection expiration date was tentatively scheduled for two years.
- torasemide,
- classical constant-temperature experiment,
- stability,
- expiration date

References

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[2]	国家食品与药品监督管理局.托拉塞米质量标准(试行)YBH05982005[S]. 2005:1.
[3]	美国药典委员会. 美国药典(第34修订版)[S]. 北京:化学工业出版社,2011:4474.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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