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Volume 34 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(4): 357-358,384

GAO Min, YANG Yingbo, LIN Li, YING Lingxuan, SUN Lianna, XIAO Wei. Analysis of medication rules of TCM for perimenopausal syndrome based on literature mining[J]. Journal of Pharmaceutical Practice and Service, 2023, 41(1): 31-35. doi: 10.12206/j.issn.2097-2024.202203034
Citation: ZHANG Yanqin, XU Xiaohong. Predicting expiration date of torasemide injection by classical constant-temperature experiment[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 357-358,384. doi: 10.3969/j.issn.1006-0111.2016.04.019
shu

Predicting expiration date of torasemide injection by classical constant-temperature experiment

doi: 10.3969/j.issn.1006-0111.2016.04.019
  • 1.

    Xi'an Medicine Supply Station, Lanzhou Military Region, Xi'an 710043, China,

  • 2.

    Chengdu Medical College, Chengdu, 610500, China

  • Received Date: 2015-10-13
  • Rev Recd Date: 2016-04-12
  • Objective To investigate the stability of torasemide injection and predict its expiration date in room temperatue. Methods The contents of torasemide were determined by HPLC. The expiration date was predicted by classical constant-temperature experiment. Results The contents of torasemide degradation with time according to a first order reaction at room temperature (25℃). The disintegration rate constant K was K25℃=5.1869×10-6 h-1 and the expiration date of torasemide injection was t0.9=2.32 years. Conclusion The torasemide injection expiration date was tentatively scheduled for two years.
  • [1] 胡瑞钺,田波,喻建勇.托拉塞米的临床应用与比较探讨[J].中国医药导报,2010,7(2):189-190.
    [2] 国家食品与药品监督管理局.托拉塞米质量标准(试行)YBH05982005[S]. 2005:1.
    [3] 美国药典委员会. 美国药典(第34修订版)[S]. 北京:化学工业出版社,2011:4474.
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Predicting expiration date of torasemide injection by classical constant-temperature experiment

doi: 10.3969/j.issn.1006-0111.2016.04.019
  • 1. Xi'an Medicine Supply Station, Lanzhou Military Region, Xi'an 710043, China,
  • 2. Chengdu Medical College, Chengdu, 610500, China
  • Received Date: 2015-10-13
  • Rev Recd Date: 2016-04-12

Abstract: Objective To investigate the stability of torasemide injection and predict its expiration date in room temperatue. Methods The contents of torasemide were determined by HPLC. The expiration date was predicted by classical constant-temperature experiment. Results The contents of torasemide degradation with time according to a first order reaction at room temperature (25℃). The disintegration rate constant K was K25℃=5.1869×10-6 h-1 and the expiration date of torasemide injection was t0.9=2.32 years. Conclusion The torasemide injection expiration date was tentatively scheduled for two years.

GAO Min, YANG Yingbo, LIN Li, YING Lingxuan, SUN Lianna, XIAO Wei. Analysis of medication rules of TCM for perimenopausal syndrome based on literature mining[J]. Journal of Pharmaceutical Practice and Service, 2023, 41(1): 31-35. doi: 10.12206/j.issn.2097-2024.202203034
Citation: ZHANG Yanqin, XU Xiaohong. Predicting expiration date of torasemide injection by classical constant-temperature experiment[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 357-358,384. doi: 10.3969/j.issn.1006-0111.2016.04.019
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