Predicting expiration date of torasemide injection by classical constant-temperature experiment

Key words: 
• torasemide /
• classical constant-temperature experiment /
• stability /
• expiration date

Abstract: Objective To investigate the stability of torasemide injection and predict its expiration date in room temperatue. Methods The contents of torasemide were determined by HPLC. The expiration date was predicted by classical constant-temperature experiment. Results The contents of torasemide degradation with time according to a first order reaction at room temperature (25℃). The disintegration rate constant K was K25℃=5.1869×10^-6 h^-1 and the expiration date of torasemide injection was t_0.9=2.32 years. Conclusion The torasemide injection expiration date was tentatively scheduled for two years.