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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(4): 380-384

LIU Liu, FEI Sujuan. A Meta-analysis of Bifidobacterium viable triple capsule on Helicobacter pylori eradication during clinical therapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 380-384. doi: 10.3969/j.issn.1006-0111.2016.04.025
Citation: LIU Liu, FEI Sujuan. A Meta-analysis of Bifidobacterium viable triple capsule on Helicobacter pylori eradication during clinical therapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 380-384. doi: 10.3969/j.issn.1006-0111.2016.04.025
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A Meta-analysis of Bifidobacterium viable triple capsule on Helicobacter pylori eradication during clinical therapy

doi: 10.3969/j.issn.1006-0111.2016.04.025
  • 1.

    Xuzhou Medical College, Xuzhou 221002, China

  • 2.

    The Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China

  • Received Date: 2015-11-16
  • Rev Recd Date: 2016-05-10
  • Objective To evaluate the effecacy of Bifidobacterium viable triple capsule on anti-Helicobacter pylori (Hp) treatment and its adverse reactions during eradication therapy. Methods Trials on the effect of Bifidobacterium viable triple capsule on Hp eradication were analyzed by Meta-analysis with the software Stata 12.0 for comprehensive quantitative analysis of its clinical efficacy and adverse reactions during treatment. Results Eight randomly controlled trials (n=1144) were included. Pooled Hp eradication rates were 85.91% and 69.21% for patients with and without Bifidobacterium viable triple capsule respectively, with the odds ratio (OR) being 3.07 (95% CI=2.25~4.19, test for overall effect Z=7.08, P<0.01); the occurrences of total adverse reactions were 7.58% and 20.87% respectively, with the summary OR being 0.42 (95% CI=0.29~0.61, test for overall effect Z=4.48, P<0.01). The difference of the two groups was statistically significant. Conclusion Current evidence shows that Bifidobacterium viable triple capsule could increase eradication rate of anti-Hp treatment and improve adverse reactions during therapy.
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    [11] 檀心广, 米永刚, 杨杨. 培菲康对幽门螺杆菌感染慢性胃炎治疗的价值[J]. 海南医学, 2011, 22(19):25-26.
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    [13] 任珺, 郑京华, 魏虹. 培菲康联合四联疗法治疗难治性幽门螺杆菌感染54例疗效观察[J]. 海军医学杂志, 2013, 34(3):178-180.
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A Meta-analysis of Bifidobacterium viable triple capsule on Helicobacter pylori eradication during clinical therapy

doi: 10.3969/j.issn.1006-0111.2016.04.025
  • 1. Xuzhou Medical College, Xuzhou 221002, China
  • 2. The Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China
  • Received Date: 2015-11-16
  • Rev Recd Date: 2016-05-10

Abstract: Objective To evaluate the effecacy of Bifidobacterium viable triple capsule on anti-Helicobacter pylori (Hp) treatment and its adverse reactions during eradication therapy. Methods Trials on the effect of Bifidobacterium viable triple capsule on Hp eradication were analyzed by Meta-analysis with the software Stata 12.0 for comprehensive quantitative analysis of its clinical efficacy and adverse reactions during treatment. Results Eight randomly controlled trials (n=1144) were included. Pooled Hp eradication rates were 85.91% and 69.21% for patients with and without Bifidobacterium viable triple capsule respectively, with the odds ratio (OR) being 3.07 (95% CI=2.25~4.19, test for overall effect Z=7.08, P<0.01); the occurrences of total adverse reactions were 7.58% and 20.87% respectively, with the summary OR being 0.42 (95% CI=0.29~0.61, test for overall effect Z=4.48, P<0.01). The difference of the two groups was statistically significant. Conclusion Current evidence shows that Bifidobacterium viable triple capsule could increase eradication rate of anti-Hp treatment and improve adverse reactions during therapy.

LIU Liu, FEI Sujuan. A Meta-analysis of Bifidobacterium viable triple capsule on Helicobacter pylori eradication during clinical therapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 380-384. doi: 10.3969/j.issn.1006-0111.2016.04.025
Citation: LIU Liu, FEI Sujuan. A Meta-analysis of Bifidobacterium viable triple capsule on Helicobacter pylori eradication during clinical therapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 380-384. doi: 10.3969/j.issn.1006-0111.2016.04.025
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