Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states

WANG Yun; CHAI Yifeng; ZHU Zhenyu

doi:10.3969/j.issn.1006-0111.2017.02.003

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2017 > 35(2): 108-111,140

WANG Yun, CHAI Yifeng, ZHU Zhenyu. Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003

Citation:

WANG Yun, CHAI Yifeng, ZHU Zhenyu. Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003

Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states

doi: 10.3969/j.issn.1006-0111.2017.02.003

Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2016-12-05
Rev Recd Date: 2016-12-27

Abstract

In recent years, pharmacokinetics of traditional Chinese medicine has become essential for the modernization of traditional Chinese medicine. Pharmacokinetics is an important means for connecting traditional Chinese medicine with western medicine. Medications exert efficacy only when there is sufficient concentration at the target sites. The drug concentration is not only related to the dosage, but is also closely correlated to the metabolic processes in human body. Most pharmacokinetic studies of traditional Chinese medicine are based on healthy animals, which ignore significant changes of pharmacokinetic parameters in the diseased state. In this paper, the comparative pharmacokinetics of the traditional Chinese medicine based on animal models in their diseased states was reviewed. Developmental trends of pharmacokinetics of traditional Chinese medicine with different animal models were also discussed.
- pathological state,
- animal model,
- pharmacokinetics,
- modernization of traditional Chinese medicine

References

[1]	郭涛. 新编药物动力学[M]. 北京:中国科学技术出版社,2005:338.
[2]	Xu B, Li P, Zhang G. Comparative pharmacokinetics of puerarin, daidzin, baicalin, glycyrrhizic acid, liquiritin, berberine, palmatine and jateorhizine by liquid chromatography-mass spectrometry after oral administration of Gegenqinlian decoction and active components alignment (ACA) to rats[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2015, 988:33-44.
[3]	Chen Y, Li Y, Wang Y, et al. Comparative pharmacokinetics of active alkaloids after oral administration of Rhizoma Coptidis extract and Wuji Wan formulas in rat using a UPLC-MS/MS method[J]. Eur J Drug Metab Pharmacokinet, 2015, 40(1):67-74.
[4]	Liu Y, Wang D, Yang G, et al. Comparative pharmacokinetics and brain distribution of magnolol and honokiol after oral administration of Magnolia officinalis cortex extract and its compatibility with other herbal medicines in Zhi-Zi-Hou-Po Decoction to rats[J]. Biomed Chromatogr:BMC, 2015, 30(3):369-375.
[5]	Xie JT, Wang A, Mehendale S, et al. Anti-diabetic effects of Gymnema yunnanense extract[J]. Pharmacol Res, 2003, 47(4):323-329.
[6]	Feng Y, Liu Z, Peng Y, et al. Validated LC-MS method for simultaneous quantitation of catalpol and harpagide in rat plasma:application to a comparative pharmacokinetic study in normal and diabetic rats after oral administration of Zeng-Ye-Decoction[J]. Biomed Chromatogr:BMC, 2013, 27(11):1503-1510.
[7]	He LH, Li J, Deng YX, et al. Comparative investigation on the pharmacokinetics of geniposide in type 2 diabetic and normal rats after oral administration of Fructus Gradeniae extract[J]. J Chromatogr B Analyt Technol BiomedLife Sci, 2016, 1033:180-186.
[8]	袁铭兰,田玉芳, 孙晨. 苦荞提取物中槲皮素在糖尿病大鼠体内的药动学研究[J]. 中华灾害救援医学, 2015, 3(8):445-449.
[9]	范惠霞,邓志鹏,王福文,等. 刺五加注射液在正常大鼠与脑缺血-再灌注损伤疾病大鼠体内药动学比较[J]. 中成药, 2015, 37(6):1215-1221.
[10]	邵明晶,冯芳. 蒽醌在正常及酒精肝损伤大鼠的药动学比较[J]. 广州化工, 2015, 43(6):53-56.
[11]	Yang T, Liu S, Wang CH, et al. Comparative pharmacokinetic and tissue distribution profiles of four major bioactive components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe[J]. J Pharm Biomed Anal, 2015, 114:152-158.
[12]	Yang T, Liu S, Zheng TH, et al. Comparative pharmacokinetics and tissue distribution profiles of lignan components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe[J]. J Ethnopharmacol, 2015, 166:305-312.
[13]	Zhu H, Bi K, Han F, et al. Simultaneous determination of two iridoid glycosides, two anthraquinones and four flavonoid glycosides of Zhi-Zi-Da-Huang decoction in rat plasma by UFLC-MS/MS:application to a comparative pharmacokinetic study in normal and cholestatic liver injury rats[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2014, 960:116-125.
[14]	Liu R, Ma R, Yu C, et al. Quantitation of eleven active compounds of Aidi injection in rat plasma and its application to comparative pharmacokinetic study[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2016, 1026:105-113.
[15]	Chen J, Chen Z, Ma L, et al. Development of determination of four analytes of Zhi-Shao-San decoction using LC-MS/MS and its application to comparative pharmacokinetics in normal and irritable bowel syndrome rat plasma[J]. Biomed Chromatogr:BMC, 2014, 28(10):1384-1392.
[16]	Zhao M, Qian D, Shang E X, et al. Comparative pharmacokinetics of the main compounds of Shanzhuyu extract after oral administration in normal and chronic kidney disease rats[J]. J Ethnopharmacol, 2015, 173:280-286.
[17]	Zhao M, Qian D, Liu P, et al. Comparative pharmacokinetics of catalpol and acteoside in normal and chronic kidney disease rats after oral administration of Rehmannia glutinosa extract[J]. Biomed Chromatogr:BMC, 2015, 29(12):1842-1848.
[18]	He W, Liu G, Cai H, et al. Integrated pharmacokinetics of five protoberberine-type alkaloids in normal and insomnic rats after single and multiple oral administration of Jiao-Tai-Wan[J]. J Ethnopharmacol, 2014, 154(3):635-644.
[19]	Zhao X, Ma T, Zhang C, et al. Simultaneous determination of senkyunolide I and senkyunolide H in rat plasma by LC-MS:application to a comparative pharmacokinetic study in normal and migrainous rats after oral administration of Chuanxiong Rhizoma extract[J]. Biomed Chromatogr:BMC, 2015, 29(9):1297-1303.
[20]	Wang YH, Hong YL, Feng Y, et al. Comparative pharmacokinetics of senkyunolide I in a rat model of migraine versus normal controls[J]. Eur J Drug Metab Pharmacokinet, 2012, 37(2):91-97.
[21]	朱黎霞,张英丰. 基于微透析技术结合液质联用的丹酚酸B正常和高脂血症大鼠药动学比较研究[J]. 中草药, 2015, 46(1):90-96.
[22]	冯彬彬,张建海,牛小花,等. 川芎嗪、阿魏酸和延胡索乙素在模型与正常大鼠体内药动学比较研究[J]. 中草药, 2015, 46(10):1493-1497.
[23]	Wu Y, Ai Y, Wang F, et al. Simultaneous determination of four secoiridoid and iridoid glycosides in rat plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application to a comparative pharmacokinetic study[J]. Biomed chromatogr:BMC, 2015, 30(2):97-104.
[24]	Wu Y, Wang F, Ai Y, et al. Simultaneous determination of seven coumarins by UPLC-MS/MS:Application to a comparative pharmacokinetic study in normal and arthritic rats after oral administration of Huo Luo Xiao Ling Dan or single-herb extract[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2015, 991:108-117.
[25]	姜丽,高萌,屈飞,等. 基于HPLC-MS/MS研究麻杏石甘汤在正常及RSV肺炎感染模型大鼠体内的药动学[J]. 中国中药杂志, 2015, 40(13):2649-2655.
[26]	Gong XH, Li Y, Zhang RQ, et al. The synergism mechanism of Rhubarb Anthraquinones on constipation elucidated by comparative pharmacokinetics of Rhubarb extract between normal and diseased rats[J]. Eur J DrugMetab Pharmacokinet, 2015, 40(4):379-388.
[27]	孟祥乐,李红伟,韩永龙,等. 栀子-连翘药对大鼠体内药动学变化特征研究[J]. 中国新药杂志, 2015, 24(17):2003-2009,2024.
[28]	Zeng XY, Dong S, He NN, et al. Comparative pharmacokinetics of arctigenin in normal and type 2 diabetic rats after oral and intravenous administration[J]. Fitoterapia, 2015, 105:119-126.

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通讯作者: 陈斌, bchen63@163.com

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Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states

Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2016-12-05

Rev Recd Date: 2016-12-27

Key words:

pathological state /
animal model /
pharmacokinetics /
modernization of traditional Chinese medicine

Abstract: In recent years, pharmacokinetics of traditional Chinese medicine has become essential for the modernization of traditional Chinese medicine. Pharmacokinetics is an important means for connecting traditional Chinese medicine with western medicine. Medications exert efficacy only when there is sufficient concentration at the target sites. The drug concentration is not only related to the dosage, but is also closely correlated to the metabolic processes in human body. Most pharmacokinetic studies of traditional Chinese medicine are based on healthy animals, which ignore significant changes of pharmacokinetic parameters in the diseased state. In this paper, the comparative pharmacokinetics of the traditional Chinese medicine based on animal models in their diseased states was reviewed. Developmental trends of pharmacokinetics of traditional Chinese medicine with different animal models were also discussed.

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Reference (28)

[1]	郭涛. 新编药物动力学[M]. 北京:中国科学技术出版社,2005:338.
[2]	Xu B, Li P, Zhang G. Comparative pharmacokinetics of puerarin, daidzin, baicalin, glycyrrhizic acid, liquiritin, berberine, palmatine and jateorhizine by liquid chromatography-mass spectrometry after oral administration of Gegenqinlian decoction and active components alignment (ACA) to rats[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2015, 988:33-44.
[3]	Chen Y, Li Y, Wang Y, et al. Comparative pharmacokinetics of active alkaloids after oral administration of Rhizoma Coptidis extract and Wuji Wan formulas in rat using a UPLC-MS/MS method[J]. Eur J Drug Metab Pharmacokinet, 2015, 40(1):67-74.
[4]	Liu Y, Wang D, Yang G, et al. Comparative pharmacokinetics and brain distribution of magnolol and honokiol after oral administration of Magnolia officinalis cortex extract and its compatibility with other herbal medicines in Zhi-Zi-Hou-Po Decoction to rats[J]. Biomed Chromatogr:BMC, 2015, 30(3):369-375.
[5]	Xie JT, Wang A, Mehendale S, et al. Anti-diabetic effects of Gymnema yunnanense extract[J]. Pharmacol Res, 2003, 47(4):323-329.
[6]	Feng Y, Liu Z, Peng Y, et al. Validated LC-MS method for simultaneous quantitation of catalpol and harpagide in rat plasma:application to a comparative pharmacokinetic study in normal and diabetic rats after oral administration of Zeng-Ye-Decoction[J]. Biomed Chromatogr:BMC, 2013, 27(11):1503-1510.
[7]	He LH, Li J, Deng YX, et al. Comparative investigation on the pharmacokinetics of geniposide in type 2 diabetic and normal rats after oral administration of Fructus Gradeniae extract[J]. J Chromatogr B Analyt Technol BiomedLife Sci, 2016, 1033:180-186.
[8]	袁铭兰,田玉芳, 孙晨. 苦荞提取物中槲皮素在糖尿病大鼠体内的药动学研究[J]. 中华灾害救援医学, 2015, 3(8):445-449.
[9]	范惠霞,邓志鹏,王福文,等. 刺五加注射液在正常大鼠与脑缺血-再灌注损伤疾病大鼠体内药动学比较[J]. 中成药, 2015, 37(6):1215-1221.
[10]	邵明晶,冯芳. 蒽醌在正常及酒精肝损伤大鼠的药动学比较[J]. 广州化工, 2015, 43(6):53-56.
[11]	Yang T, Liu S, Wang CH, et al. Comparative pharmacokinetic and tissue distribution profiles of four major bioactive components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe[J]. J Pharm Biomed Anal, 2015, 114:152-158.
[12]	Yang T, Liu S, Zheng TH, et al. Comparative pharmacokinetics and tissue distribution profiles of lignan components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe[J]. J Ethnopharmacol, 2015, 166:305-312.
[13]	Zhu H, Bi K, Han F, et al. Simultaneous determination of two iridoid glycosides, two anthraquinones and four flavonoid glycosides of Zhi-Zi-Da-Huang decoction in rat plasma by UFLC-MS/MS:application to a comparative pharmacokinetic study in normal and cholestatic liver injury rats[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2014, 960:116-125.
[14]	Liu R, Ma R, Yu C, et al. Quantitation of eleven active compounds of Aidi injection in rat plasma and its application to comparative pharmacokinetic study[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2016, 1026:105-113.
[15]	Chen J, Chen Z, Ma L, et al. Development of determination of four analytes of Zhi-Shao-San decoction using LC-MS/MS and its application to comparative pharmacokinetics in normal and irritable bowel syndrome rat plasma[J]. Biomed Chromatogr:BMC, 2014, 28(10):1384-1392.
[16]	Zhao M, Qian D, Shang E X, et al. Comparative pharmacokinetics of the main compounds of Shanzhuyu extract after oral administration in normal and chronic kidney disease rats[J]. J Ethnopharmacol, 2015, 173:280-286.
[17]	Zhao M, Qian D, Liu P, et al. Comparative pharmacokinetics of catalpol and acteoside in normal and chronic kidney disease rats after oral administration of Rehmannia glutinosa extract[J]. Biomed Chromatogr:BMC, 2015, 29(12):1842-1848.
[18]	He W, Liu G, Cai H, et al. Integrated pharmacokinetics of five protoberberine-type alkaloids in normal and insomnic rats after single and multiple oral administration of Jiao-Tai-Wan[J]. J Ethnopharmacol, 2014, 154(3):635-644.
[19]	Zhao X, Ma T, Zhang C, et al. Simultaneous determination of senkyunolide I and senkyunolide H in rat plasma by LC-MS:application to a comparative pharmacokinetic study in normal and migrainous rats after oral administration of Chuanxiong Rhizoma extract[J]. Biomed Chromatogr:BMC, 2015, 29(9):1297-1303.
[20]	Wang YH, Hong YL, Feng Y, et al. Comparative pharmacokinetics of senkyunolide I in a rat model of migraine versus normal controls[J]. Eur J Drug Metab Pharmacokinet, 2012, 37(2):91-97.
[21]	朱黎霞,张英丰. 基于微透析技术结合液质联用的丹酚酸B正常和高脂血症大鼠药动学比较研究[J]. 中草药, 2015, 46(1):90-96.
[22]	冯彬彬,张建海,牛小花,等. 川芎嗪、阿魏酸和延胡索乙素在模型与正常大鼠体内药动学比较研究[J]. 中草药, 2015, 46(10):1493-1497.
[23]	Wu Y, Ai Y, Wang F, et al. Simultaneous determination of four secoiridoid and iridoid glycosides in rat plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application to a comparative pharmacokinetic study[J]. Biomed chromatogr:BMC, 2015, 30(2):97-104.
[24]	Wu Y, Wang F, Ai Y, et al. Simultaneous determination of seven coumarins by UPLC-MS/MS:Application to a comparative pharmacokinetic study in normal and arthritic rats after oral administration of Huo Luo Xiao Ling Dan or single-herb extract[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2015, 991:108-117.
[25]	姜丽,高萌,屈飞,等. 基于HPLC-MS/MS研究麻杏石甘汤在正常及RSV肺炎感染模型大鼠体内的药动学[J]. 中国中药杂志, 2015, 40(13):2649-2655.
[26]	Gong XH, Li Y, Zhang RQ, et al. The synergism mechanism of Rhubarb Anthraquinones on constipation elucidated by comparative pharmacokinetics of Rhubarb extract between normal and diseased rats[J]. Eur J DrugMetab Pharmacokinet, 2015, 40(4):379-388.
[27]	孟祥乐,李红伟,韩永龙,等. 栀子-连翘药对大鼠体内药动学变化特征研究[J]. 中国新药杂志, 2015, 24(17):2003-2009,2024.
[28]	Zeng XY, Dong S, He NN, et al. Comparative pharmacokinetics of arctigenin in normal and type 2 diabetic rats after oral and intravenous administration[J]. Fitoterapia, 2015, 105:119-126.

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Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states

doi: 10.3969/j.issn.1006-0111.2017.02.003

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References

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通讯作者: 陈斌, bchen63@163.com

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