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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2017  >  35(2): 116-120,125

WANG Yeqing, XIE Yaoyu, ZHANG Hui, WU Hong, GUO Meili. Protective effects of the total bakkenolides from Petasites. tricholobus on high altitude hypoxia[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 116-120,125. doi: 10.3969/j.issn.1006-0111.2017.02.005
Citation: WANG Yeqing, XIE Yaoyu, ZHANG Hui, WU Hong, GUO Meili. Protective effects of the total bakkenolides from Petasites. tricholobus on high altitude hypoxia[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 116-120,125. doi: 10.3969/j.issn.1006-0111.2017.02.005
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Protective effects of the total bakkenolides from Petasites. tricholobus on high altitude hypoxia

doi: 10.3969/j.issn.1006-0111.2017.02.005
  • 1.

    Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, 200433 China

  • 2.

    Department of Aerospace Medicine, Naval Medical Research Institute, Shanghai, 200433 China

  • 3.

    Department of Cardiology, Changhai Hospital Affiliated to Second Military Medical University, Shanghai, 200433 China

  • Received Date: 2016-11-14
  • Rev Recd Date: 2016-12-07
  • Objective To study the protective effects of the total bakkenolides from P. tricholobus on high altitude hypoxia. Method Normobaric hypoxia model and acute hypobaric hypoxia model in mice, hypobaric hypoxia model in rats were established for this study. Survival time and survival rate of mice were recorded. The level of blood sugar and glycogen, adenosine triphosphate (ATP), lactic acid (LD), lactic dehydrogenase (LDH) were detected in different organs of rats. Results The total bakkenolides significantly prolonged the survival time of mice in normobaric hypoxia model and reduced the death rate of mice in acute hypobaric hypoxia model. The total bakkenolides suppressed blood sugar level in rats and increased the glycogen level in rat liver, skeletal muscle and myocardium. It also elevated the ATP content in rat brain, liver, skeletal muscle and myocardium. Meanwhile, the content of LD in plasma, skeletal muscle, myocardium and LDH level in myocardium were reduced. Conclusion The total bakkenolides from P. tricholobus have protective effect on normobaric hypoxia model and acute hypobaric hypoxia model in mice as well as hypobaric hypoxia model in rats. Its anti-hypoxia efficacy at high altitude may relate to the increased blood sugar, glycogen, and ATP level and reduced LD, LDH level in major organs.
  • [1] 中科院中国植物志编辑委员会.中国植物志[M].北京:科学出版社,1999:94-100.
    [2] 国家中医药管理局《中华本草》编委会.中华本草[M].上海:上海科学技术出版社,1999:914-916.
    [3] 王玉亮,郭美丽,张戈,等.毛裂蜂斗菜根茎的化学成分及抗炎活性[J].第二军医大学学报,2006,27(11):1210-1213.
    [4] Zhang N,Guo ML,Zhang G,et al.A new neuroprotective bakkenolide from the rhizome of Petasitestricholobus[J].Chin Chem Lett,2008,19(7):841-844.
    [5] Wang YL,Li RP,Guo ML,et al.Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities[J].Planta Med,2009,75(3):230-235.
    [6] 李余先,王燕,郭美丽.蜂斗菜的化学成分研究[J].第二军医大学学报,2010,31(7):779-781.
    [7] 谢曜宇,李余先,孙一鸣,等.蜂斗菜根茎中的一个新倍半萜成分及其抗缺氧活性[J].药学学报,2016,51(8):1285-1289.
    [8] Jiang Q,Xia YY,He JM,et al.Total bakkenolides protects neurons against cerebral ischemic injury through inhibition of NF-κB activation[J].CNS Neurol Disord Drug Targets,2014,13(5):874-884.
    [9] Jiang Q, Li RP,Tang Y,et al.Bakkenolide-Ⅲa protects against cerebral damage via inhibiting NF-κB activation[J].CNS Neurosci Ther,2015,21(12):943-952.
    [10] Netzer N,Strohl K,Faulhaber M,et al.Hypoxia-related altitude illnesses[J].J Travel Med,2013,20(4):247-255.
    [11] Imray C,Wright A,Subudhi A,et al.Acute mountain sickness:pathophysiology,prevention,and treatment[J].Prog Cardiovasc Dis,2010,52(6):467-484.
    [12] Collier DJ,Wolff CB,Hedges AM,et al.Benzolamide improves oxygenation and reduces acute mountain sickness during a high-altitude trek and has fewer side effects than acetazolamide at sea level[J].Pharmacol Res Perspect,2016,4(3):1-12.
    [13] Mirtschink P,KrekW.Hypoxia-driven glycolytic and fructolytic metabolic programs:Pivotal to hypertrophic heart disease[J].Biochim Biophys Acta,2016,2(11):1822-1828.
    [14] 马慧萍,何蕾,王昕,等.藏紫菀总黄酮对模拟高原缺氧小鼠的保护作用[J].解放军医药杂志,2016,28(6):1-4.
    [15] 景临林,马慧萍,樊鹏程.矮垂头菊乙醇提取物的体外自由基清除活性及其对高原缺氧小鼠的保护作用研究[J].天然产物研究与开发,2015,27:1815-1820.
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Protective effects of the total bakkenolides from Petasites. tricholobus on high altitude hypoxia

doi: 10.3969/j.issn.1006-0111.2017.02.005
  • 1. Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, 200433 China
  • 2. Department of Aerospace Medicine, Naval Medical Research Institute, Shanghai, 200433 China
  • 3. Department of Cardiology, Changhai Hospital Affiliated to Second Military Medical University, Shanghai, 200433 China
  • Received Date: 2016-11-14
  • Rev Recd Date: 2016-12-07

Abstract: Objective To study the protective effects of the total bakkenolides from P. tricholobus on high altitude hypoxia. Method Normobaric hypoxia model and acute hypobaric hypoxia model in mice, hypobaric hypoxia model in rats were established for this study. Survival time and survival rate of mice were recorded. The level of blood sugar and glycogen, adenosine triphosphate (ATP), lactic acid (LD), lactic dehydrogenase (LDH) were detected in different organs of rats. Results The total bakkenolides significantly prolonged the survival time of mice in normobaric hypoxia model and reduced the death rate of mice in acute hypobaric hypoxia model. The total bakkenolides suppressed blood sugar level in rats and increased the glycogen level in rat liver, skeletal muscle and myocardium. It also elevated the ATP content in rat brain, liver, skeletal muscle and myocardium. Meanwhile, the content of LD in plasma, skeletal muscle, myocardium and LDH level in myocardium were reduced. Conclusion The total bakkenolides from P. tricholobus have protective effect on normobaric hypoxia model and acute hypobaric hypoxia model in mice as well as hypobaric hypoxia model in rats. Its anti-hypoxia efficacy at high altitude may relate to the increased blood sugar, glycogen, and ATP level and reduced LD, LDH level in major organs.

WANG Yeqing, XIE Yaoyu, ZHANG Hui, WU Hong, GUO Meili. Protective effects of the total bakkenolides from Petasites. tricholobus on high altitude hypoxia[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 116-120,125. doi: 10.3969/j.issn.1006-0111.2017.02.005
Citation: WANG Yeqing, XIE Yaoyu, ZHANG Hui, WU Hong, GUO Meili. Protective effects of the total bakkenolides from Petasites. tricholobus on high altitude hypoxia[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 116-120,125. doi: 10.3969/j.issn.1006-0111.2017.02.005
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