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Volume 35 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2017  >  35(2): 150-153

SU Jiangtao, HU Changjie, ZHANG Hanqiao, ZHANG Menglin, XIE Weihong, MI Zhiyuan. Determination of amlodipine and telmisartan in the compound tablet by first derivative UV spectropho-tometry[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 150-153. doi: 10.3969/j.issn.1006-0111.2017.02.013
Citation: SU Jiangtao, HU Changjie, ZHANG Hanqiao, ZHANG Menglin, XIE Weihong, MI Zhiyuan. Determination of amlodipine and telmisartan in the compound tablet by first derivative UV spectropho-tometry[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 150-153. doi: 10.3969/j.issn.1006-0111.2017.02.013
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Determination of amlodipine and telmisartan in the compound tablet by first derivative UV spectropho-tometry

doi: 10.3969/j.issn.1006-0111.2017.02.013

  • Biology and Food Engineering College, Hubei University of Technology, Wuhan 430068, China

  • Received Date: 2016-07-14
  • Rev Recd Date: 2016-10-12
  • Objective To determine telmisartan and amlodipine assay in the compound tablet. Methods First derivative UV spectrophotometry was used at wavelength 236 nm for telmisartan and 390 nm for amlodipine. Results Telmisartan content has a good linear relationship in the concentration range of (4~20)×10-3 mg/ml. The standard curve equation is Y=0.004 3 X-0.000 5 and correlation coefficient R2=0.999 3. Amlodipine content has a good linear relationship in the concentration range of (10~90)×10-3 mg/ml. The standard curve equation is Y=0.000 3 X+0.000 2 and correlation coefficient R2=0.999 5. Conclusion The assay results from this method are consistent with the results from HPLC. This procedure provides a specific, accurate and precise method to assay the amlodipine and telmisartan in compound tablet.
  • [1] Kottai Muthu A, Sankhla R, Gupta Sh, et al.Development and validation of a reversed phase HPLC method for simultaneous determination of amlodipine and telmisartan in pharmaceutical dosage form[J]. J Appl Chem Res, 2010,12:43-52.
    [2] 袁月,姚双全,王双飞.紫外双波长法检测葡萄糖降解产物5-HMF的研究[J].现代化工, 2016,36(2):176-178.
    [3] 刘荣.二阶导数紫外分光光度法测定复方麻黄素滴鼻液中盐酸麻黄素的含量[J].云南医药,2014,35(3):387-388.
    [4] 肖艳,韩娟,冯霞光,等.导数分光光度法在药物分析中的应用[J].光谱实验室,2006,23(3):420-427.
    [5] 王守宝,杜冠华.复方抗高血压药物的研究现状分析[J].中华临床医师杂志(电子版), 2012,6(10):2764-2768.
    [6] 国家药典委员会.中华人民共和国药典2015年版四部附录[S].北京:中国医药科技出版社,2015:374-377.
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Determination of amlodipine and telmisartan in the compound tablet by first derivative UV spectropho-tometry

doi: 10.3969/j.issn.1006-0111.2017.02.013
  • Biology and Food Engineering College, Hubei University of Technology, Wuhan 430068, China
  • Received Date: 2016-07-14
  • Rev Recd Date: 2016-10-12

Abstract: Objective To determine telmisartan and amlodipine assay in the compound tablet. Methods First derivative UV spectrophotometry was used at wavelength 236 nm for telmisartan and 390 nm for amlodipine. Results Telmisartan content has a good linear relationship in the concentration range of (4~20)×10-3 mg/ml. The standard curve equation is Y=0.004 3 X-0.000 5 and correlation coefficient R2=0.999 3. Amlodipine content has a good linear relationship in the concentration range of (10~90)×10-3 mg/ml. The standard curve equation is Y=0.000 3 X+0.000 2 and correlation coefficient R2=0.999 5. Conclusion The assay results from this method are consistent with the results from HPLC. This procedure provides a specific, accurate and precise method to assay the amlodipine and telmisartan in compound tablet.

SU Jiangtao, HU Changjie, ZHANG Hanqiao, ZHANG Menglin, XIE Weihong, MI Zhiyuan. Determination of amlodipine and telmisartan in the compound tablet by first derivative UV spectropho-tometry[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 150-153. doi: 10.3969/j.issn.1006-0111.2017.02.013
Citation: SU Jiangtao, HU Changjie, ZHANG Hanqiao, ZHANG Menglin, XIE Weihong, MI Zhiyuan. Determination of amlodipine and telmisartan in the compound tablet by first derivative UV spectropho-tometry[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 150-153. doi: 10.3969/j.issn.1006-0111.2017.02.013
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