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ZHANG Xueting, YUN Chao, CHEN Zhenzhen, TAO Chun, SONG Hongtao. Study on sirolimus solubilization technology based on in vitro dissolution and in vivo bioavailability[J]. Journal of Pharmaceutical Practice and Service, 2020, 38(5): 441-446, 457. doi: 10.12206/j.issn.1006-0111.201910022
Citation:
SU Jiangtao, HU Changjie, ZHANG Hanqiao, ZHANG Menglin, XIE Weihong, MI Zhiyuan. Determination of amlodipine and telmisartan in the compound tablet by first derivative UV spectropho-tometry[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 150-153. doi: 10.3969/j.issn.1006-0111.2017.02.013
Determination of amlodipine and telmisartan in the compound tablet by first derivative UV spectropho-tometry
Biology and Food Engineering College, Hubei University of Technology, Wuhan 430068, China
Received Date: 2016-07-14
Rev Recd Date:
2016-10-12
Abstract
Objective To determine telmisartan and amlodipine assay in the compound tablet. Methods First derivative UV spectrophotometry was used at wavelength 236 nm for telmisartan and 390 nm for amlodipine. Results Telmisartan content has a good linear relationship in the concentration range of (4~20)×10-3 mg/ml. The standard curve equation is Y=0.004 3 X-0.000 5 and correlation coefficient R2=0.999 3. Amlodipine content has a good linear relationship in the concentration range of (10~90)×10-3 mg/ml. The standard curve equation is Y=0.000 3 X+0.000 2 and correlation coefficient R2=0.999 5. Conclusion The assay results from this method are consistent with the results from HPLC. This procedure provides a specific, accurate and precise method to assay the amlodipine and telmisartan in compound tablet.
Kottai Muthu A, Sankhla R, Gupta Sh, et al.Development and validation of a reversed phase HPLC method for simultaneous determination of amlodipine and telmisartan in pharmaceutical dosage form[J]. J Appl Chem Res, 2010,12:43-52.
Abstract: Objective To determine telmisartan and amlodipine assay in the compound tablet. Methods First derivative UV spectrophotometry was used at wavelength 236 nm for telmisartan and 390 nm for amlodipine. Results Telmisartan content has a good linear relationship in the concentration range of (4~20)×10-3 mg/ml. The standard curve equation is Y=0.004 3 X-0.000 5 and correlation coefficient R2=0.999 3. Amlodipine content has a good linear relationship in the concentration range of (10~90)×10-3 mg/ml. The standard curve equation is Y=0.000 3 X+0.000 2 and correlation coefficient R2=0.999 5. Conclusion The assay results from this method are consistent with the results from HPLC. This procedure provides a specific, accurate and precise method to assay the amlodipine and telmisartan in compound tablet.
ZHANG Xueting, YUN Chao, CHEN Zhenzhen, TAO Chun, SONG Hongtao. Study on sirolimus solubilization technology based on in vitro dissolution and in vivo bioavailability[J]. Journal of Pharmaceutical Practice and Service, 2020, 38(5): 441-446, 457. doi: 10.12206/j.issn.1006-0111.201910022
Citation:
SU Jiangtao, HU Changjie, ZHANG Hanqiao, ZHANG Menglin, XIE Weihong, MI Zhiyuan. Determination of amlodipine and telmisartan in the compound tablet by first derivative UV spectropho-tometry[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 150-153. doi: 10.3969/j.issn.1006-0111.2017.02.013
Kottai Muthu A, Sankhla R, Gupta Sh, et al.Development and validation of a reversed phase HPLC method for simultaneous determination of amlodipine and telmisartan in pharmaceutical dosage form[J]. J Appl Chem Res, 2010,12:43-52.
ZHANG Xueting, YUN Chao, CHEN Zhenzhen, TAO Chun, SONG Hongtao. Study on sirolimus solubilization technology based on in vitro dissolution and in vivo bioavailability[J]. Journal of Pharmaceutical Practice and Service, 2020, 38(5): 441-446, 457. doi: 10.12206/j.issn.1006-0111.201910022
ZHANG Xueting, YUN Chao, CHEN Zhenzhen, TAO Chun, SONG Hongtao. Study on sirolimus solubilization technology based on in vitro dissolution and in vivo bioavailability[J]. Journal of Pharmaceutical Practice and Service, 2020, 38(5): 441-446, 457. doi: 10.12206/j.issn.1006-0111.201910022
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