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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2017  >  35(2): 154-157,164,181

CAI Jian, LI Mingming, ZHANG Ping, FEI Chunhua, QIAN Chang, XU Feng. Drug brand preference and its effect on medication compliance and efficacy for outpatients with depres-sion[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 154-157,164,181. doi: 10.3969/j.issn.1006-0111.2017.02.014
Citation: CAI Jian, LI Mingming, ZHANG Ping, FEI Chunhua, QIAN Chang, XU Feng. Drug brand preference and its effect on medication compliance and efficacy for outpatients with depres-sion[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 154-157,164,181. doi: 10.3969/j.issn.1006-0111.2017.02.014
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Drug brand preference and its effect on medication compliance and efficacy for outpatients with depres-sion

doi: 10.3969/j.issn.1006-0111.2017.02.014
  • 1.

    Shanghai Fengxian Mental Health Center, Shanghai 201400, China

  • 2.

    Fengxian Hospital Affiliated to Southern Medical University, Shanghai 201400, China

  • Received Date: 2016-08-24
  • Rev Recd Date: 2016-12-16
  • Objective To investigate drug brand preference and its effect on medication compliance and efficacy in patients with depression, to guide patient's rational use of limited medical resources and achieve a safe and effective drug use. Methods 459 outpatients were divided into the brand drug group and the generic drug group according to the current drug therapy stage. The patients in both groups were assessed by drug brand preference and medication compliance. In the brand group, the patients with high brand preference were chosen to replace with generic medication intervention for 8 weeks. Drug education and psychological support were provided to those patients. Evaluation of therapeutic effect was conducted before and after generic replacement. Results About 1/3 patients had high response and 2/3 patients had low or no response to the brand preference. Patients on brand drugs had slightly higher brand preference than patients with generic drugs. Overall, the patients' response to brand preference gradually decreased with the duration of treatment. In general, the medication compliance was acceptable. The patients taking brand drugs displayed significantly higher medication compliance than the patients taking generics. Correlation analysis showed that in brand medicine group, medication compliance was closely related to brand response, but negatively correlated with the patient's age and treatment duration. In generics group, patient medication compliance was not related to brand response, but closely related with the degree of education and negatively related with the patient's age and treatment duration. The anti-depression medication maintained same effectiveness in the generic group before and after the replacement, and no severe adverse reactions occurred. Conclusion Medication compliance for patients taking branded drugs was associated with brand response. With medication education and psychological support, alternative generic medicine treatment can give good efficacy with very minor side effects. The medical staff should provide medication education including pharmacoeconomics and the biological equivalence to guide the patients with rational use of the limited medical resources.
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    [2] Moerman DE. The meaning response and the ethics of avoiding placebos[J]. Eval Health Prof,2002,25(4):399-409.
    [3] Moerman DE. Agreement and meaning:rethinking consensus analysis[J]. J Ethnopharmacol,,2007,112(3):451-460.
    [4] Moerman DE,Jonas WB. Toward a research agenda on placebo[J]. Adv Mind Body Med,2000,16(1):33-46.
    [5] Moerman DE,Jonas WB. Deconstructing the placebo effect and finding the meaning response[J]. AnnIntern Med,2002,136(6):471-476.
    [6] 王莉,邓勋,贺帅,等. 高血压患者药物品牌内涵响应对用药选择的影响[J]. 今日药学,2010,20(5):35-38.
    [7] 曹贤芹,张静,庄丽琼,等. 门诊患者药物品牌内涵响应对用药选择及依从性的影响[J]. 今日药学,2011,21(7):444-446.
    [8] 葛悦,朱珠. 我院部分国产药与进口(合资)药使用情况简析[J].中国医院药学杂志, 2007,27(11):1576-1578.
    [9] Cai J,Ye MR,Fei CH,et al. Impact of brand-name drug worship and expectation psychology on antidepressant efficacy[J].Int J Clin Exper Med,2013,6(8):724-726.
    [10] Kesselheim AS,Gagne JJ,Franklin JM,et al. Variations in patients' perceptions and use of generic drugs:results of a national survey[J]. J Gen Intern Med,2016, 31(6):609-614.
    [11] Drozdowska A,Hermanowski T. Exploring the opinions and experiences of patients with generic substitution:a representative study of Polish society[J]. Int J Clin Pharm,2015,37(1):68-75.
    [12] Patel M,Slack M,Cooley J,et al. A cross-sectional survey of pharmacists to understand their personal preference of brand and generic over-the-counter medications used to treat common health conditions[J]. J Pharm Polic Pract,2016,9(1):1-8.
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    [15] Margolese HC,Wolf Y,Desmarais JE,et al. Loss of response after switching from brand name to generic formulations:three cases and a discussion of key clinical considerations when switching[J]. Int Clin Psychopharmacol,2010,25(3):180-182.
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    [18] Cessak G,Rokita K,Dabrowska M,et al. Therapeutic equivalence of antipsychotics and antidepressants-A systematic review[J]. Pharmacol Rep,2016,68(2):217-223.
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Drug brand preference and its effect on medication compliance and efficacy for outpatients with depres-sion

doi: 10.3969/j.issn.1006-0111.2017.02.014
  • 1. Shanghai Fengxian Mental Health Center, Shanghai 201400, China
  • 2. Fengxian Hospital Affiliated to Southern Medical University, Shanghai 201400, China
  • Received Date: 2016-08-24
  • Rev Recd Date: 2016-12-16

Abstract: Objective To investigate drug brand preference and its effect on medication compliance and efficacy in patients with depression, to guide patient's rational use of limited medical resources and achieve a safe and effective drug use. Methods 459 outpatients were divided into the brand drug group and the generic drug group according to the current drug therapy stage. The patients in both groups were assessed by drug brand preference and medication compliance. In the brand group, the patients with high brand preference were chosen to replace with generic medication intervention for 8 weeks. Drug education and psychological support were provided to those patients. Evaluation of therapeutic effect was conducted before and after generic replacement. Results About 1/3 patients had high response and 2/3 patients had low or no response to the brand preference. Patients on brand drugs had slightly higher brand preference than patients with generic drugs. Overall, the patients' response to brand preference gradually decreased with the duration of treatment. In general, the medication compliance was acceptable. The patients taking brand drugs displayed significantly higher medication compliance than the patients taking generics. Correlation analysis showed that in brand medicine group, medication compliance was closely related to brand response, but negatively correlated with the patient's age and treatment duration. In generics group, patient medication compliance was not related to brand response, but closely related with the degree of education and negatively related with the patient's age and treatment duration. The anti-depression medication maintained same effectiveness in the generic group before and after the replacement, and no severe adverse reactions occurred. Conclusion Medication compliance for patients taking branded drugs was associated with brand response. With medication education and psychological support, alternative generic medicine treatment can give good efficacy with very minor side effects. The medical staff should provide medication education including pharmacoeconomics and the biological equivalence to guide the patients with rational use of the limited medical resources.

CAI Jian, LI Mingming, ZHANG Ping, FEI Chunhua, QIAN Chang, XU Feng. Drug brand preference and its effect on medication compliance and efficacy for outpatients with depres-sion[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 154-157,164,181. doi: 10.3969/j.issn.1006-0111.2017.02.014
Citation: CAI Jian, LI Mingming, ZHANG Ping, FEI Chunhua, QIAN Chang, XU Feng. Drug brand preference and its effect on medication compliance and efficacy for outpatients with depres-sion[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 154-157,164,181. doi: 10.3969/j.issn.1006-0111.2017.02.014
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