Recent progress in pharmacology, efficacy and dosage forms of flumazenil

HOU Cheng; LU Guangzhao; LI Wenqing; ZOU Hao

doi:10.3969/j.issn.1006-0111.2017.06.002

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Flumazenil, a benzodiazepine antagonist, specifically binds the benzodiazepine receptors in central nervous system and reduces the release of gamma-aminobutyric acid. It is used for the reversal of sedative effects of benzodiazepine and benzodiazepine-induced anesthesia. In this article, the clinical applications of flumazenil and the developments of different dosage forms were reviewed.

Recent progress in pharmacology, efficacy and dosage forms of flumazenil

Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2017-08-18

Rev Recd Date: 2017-09-01

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Abstract: Flumazenil, a benzodiazepine antagonist, specifically binds the benzodiazepine receptors in central nervous system and reduces the release of gamma-aminobutyric acid. It is used for the reversal of sedative effects of benzodiazepine and benzodiazepine-induced anesthesia. In this article, the clinical applications of flumazenil and the developments of different dosage forms were reviewed.

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Recent progress in pharmacology, efficacy and dosage forms of flumazenil

doi: 10.3969/j.issn.1006-0111.2017.06.002

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