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Volume 36 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(5): 457-460

YANG Shichang, HE Jinggui, ZHOU Suyue, LI Xuemei. The retrospective study of the improvement of memantine hydrochloride on neurocognitive function in patients with ischemic stroke[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(5): 457-460. doi: 10.3969/j.issn.1006-0111.2018.05.017
Citation: YANG Shichang, HE Jinggui, ZHOU Suyue, LI Xuemei. The retrospective study of the improvement of memantine hydrochloride on neurocognitive function in patients with ischemic stroke[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(5): 457-460. doi: 10.3969/j.issn.1006-0111.2018.05.017
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The retrospective study of the improvement of memantine hydrochloride on neurocognitive function in patients with ischemic stroke

doi: 10.3969/j.issn.1006-0111.2018.05.017

  • The General Hospital of PLA, Beijing 100853, China

  • Received Date: 2018-05-23
  • Rev Recd Date: 2018-06-27
  • Objective To investigate the effect of memantine hydrochloride on improving neurocognitive function in patients with ischemic stroke. Methods Patients with hemorrhagic stroke who were treated in the officer consultation department of General Hospital of PLA from June to December 2016 were retrospectively studied. According to whether or not they were taking memantine, the patients were divided into the memantine group and the control group. The data including age, sex, BMI, follow-up time, the neurocognitive function score were collected. The neurocognitive function score was assessed by the Montreal Cognitive Assessment Scale (MoCA). Results There was no significant difference in age, BMI, and follow-up time between the two groups. The MoCA score was(19.19±3.23) in memantine group, (18.47±3.03) in control group, P=0.651;(21.06±2.62)in memantine group,(19.19±2.87) in control group,P=0.038 at 2 weeks;(23.50±2.00) in memantine group,(21.30±2.16) in control group,P=0.002 at 4 weeks;At the last follow-up, memantine group was(24.69±2.09), control group was (23.22±2.08), P=0.031. Conclusion Memantine could effectively improve neurocognitive function in patients with ischemic stroke.
  • [1] POORTHUIS MH, ALGRA AM, ALGRA A, et al. Female-and male-specific risk factors for stroke:a systematic review and Meta-analysis[J]. JAMA Neurol, 2017, 74(1):75-81.
    [2] DETANTE O, JAILLARD A, MOISAN A, et al. Biotherapies in stroke[J]. Rev Neurol (Paris), 2014, 170(12):779-798.
    [3] DAY NL, CARLE MS, FLOYD CL. Post-injury administration of a combination of memantine and 17β-estradiol is protective in a rat model of traumatic brain injury[J]. Neurochem Int, 2017, 111:57-68.
    [4] LANDUCCI E, FILIPPI L, GERACE E, et al. Neuroprotective effects of topiramate and memantine in combination with hypothermia in hypoxic-ischemic brain injury in vitro and in vivo[J]. Neurosci Lett, 2018, 668:103-107.
    [5] NASREDDINE ZS, PHILLIPS NA, BÉDIRIAN V, et al. The Montreal Cognitive Assessment, MoCA:a brief screening tool for mild cognitive impairment[J]. J Am Geriatr Soc,2005, 53(4):695-699.
    [6] 孙洪吉, 谢越, 张晓红, 等. 蒙特利尔认知评估量表在健康体检人群中的应用[J]. 中华老年心脑血管病杂志, 2014, 16(2):174-177.
    [7] DE LUCA R, LEONARDI S, SPADARO L, et al. Improving cognitive function in patients with stroke:can computerized training be the future?[J]. J Stroke Cerebrovasc Dis,2018,27(4):1055-1060.
    [8] WILD AR, AKYOL E, BROTHWELL SL, et al. Memantine block depends on agonist presentation at the NMDA receptor in substantia nigra pars compacta dopamine neurones[J]. Neuropharmacology, 2013, 73(5):138-146.
    [9] VAN WAGENINGEN H, JφRGENSEN HA, SPECHT K, et al. The effects of the glutamate antagonist memantine on brain activation to an auditory perception task[J]. Hum Brain Mapp, 2009, 30(11):3616-3624..
    [10] MEISNER F, SCHELLER C, KNEITZ S, et al. Memantine upregulates BDNF and prevents dopamine deficits in SIV-infected macaques:a novel pharmacological action of memantine[J]. Neuropsychopharmacology, 2008, 33(9):2228-2236.
    [11] LOPEZ-VALDES HE, CLARKSON AN, AO Y, et al. Memantine enhances recovery from stroke[J]. Stroke, 2014, 45(7):2093-2100.
    [12] LIU C, LIN N, WU B, et al. Neuroprotective effect of memantine combined with topiramate in hypoxic-ischemic brain injury[J]. Brain Res, 2009, 1282:173-182.
    [13] CHEN B, WANG G, LI W, et al. Memantine attenuates cell apoptosis by suppressing the calpain-caspase-3 pathway in an experimental model of ischemic stroke[J]. Exp Cell Res, 2017, 351(2):163-172.
    [14] KUMAR A,SINGH A,EKAVALI.A review on Alzheimer's disease pathophysiology and its management:an update[J]. Pharmacol Rep, 2015, 67(2):195-203.
    [15] TROTMAN M, VERMEHREN P, GIBSON CL, et al. The dichotomy of memantine treatment for ischemic stroke:dose-dependent protective and detrimental effects[J]. J Cereb Blood Flow Metab, 2015, 35(2):230-239.
    [16] CHEN ZZ, YANG DD, ZHAO Z, et al. Memantine mediates neuroprotection via regulating neurovascular unit in a mouse model of focal cerebral ischemia[J]. Life Sci, 2016, 150:8-14.
    [17] TAKAHASHI H, XIA P, CUI J, et al. Corrigendum:Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease[J]. Sci Rep, 2016, 6(1):20750.
    [18] 郭叶群. 盐酸美金刚对大鼠大脑中动脉闭塞后同侧丘脑继发损害的保护作用及其机制研究[D]. 广州:暨南大学, 2015.
    [19] WANG YC, SANCHEZ-MENDOZA EH, DOEPPNER TR, et al. Post-acute delivery of memantine promotes post-ischemic neurological recovery, peri-infarct tissue remodeling, and contralesional brain plasticity[J]. J Cereb Blood Flow Metab, 2017, 37(3):980-993.
    [20] KAFI H, SALAMZADEH J, BELADIMOGHADAM N, et al. Study of the neuroprotective effects of memantine in patients with mild to moderate ischemic stroke[J]. Iran J Pharm Res, 2014, 13(2):591-598.
    [21] MOKHTARI M, NAYEB-AGHAEI H, KOUCHEK M, et al. Effect of memantine on serum levels of neuron-specific enolase and on the glasgow coma scale in patients with moderate traumatic brain injury[J]. J Clin Pharmacol, 2018, 58(1):42-47.
    [22] BAKHSHAYESH B, HAJINORI M, SAADAT SMS, et al. Comparing the effect of memantine and placebo on clinical outcome of intracranial hemorrhage:a randomized double blind clinical trial[J].2015, 1(3):11-18.
    [23] ORGOGOZO JM, RIGAUD AS, STOFFLER A, et al. Efficacy and safety of memantine in patients with mild to moderate vascular dementia:a randomized, placebo-controlled trial (MMM 300)[J]. Stroke, 2002, 33(7):1834-1839.
    [24] 邓娜. 美金刚治疗缺血性脑卒中后失语的疗效观察[D]. 重庆:重庆医科大学, 2015.
    [25] BERTHIER ML, GREEN C, LARA JP, et al. Memantine and constraint-induced aphasia therapy in chronic poststroke aphasia[J]. Ann Neurol, 2009, 65(5):577-585.
    [26] BARBANCHO MA, BERTHIER ML, NAVAS-SANCHEZ P, et al. Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia:an ERP study[J]. Brain Lang, 2015, 145-146:1-10.
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The retrospective study of the improvement of memantine hydrochloride on neurocognitive function in patients with ischemic stroke

doi: 10.3969/j.issn.1006-0111.2018.05.017
  • The General Hospital of PLA, Beijing 100853, China
  • Received Date: 2018-05-23
  • Rev Recd Date: 2018-06-27

Abstract: Objective To investigate the effect of memantine hydrochloride on improving neurocognitive function in patients with ischemic stroke. Methods Patients with hemorrhagic stroke who were treated in the officer consultation department of General Hospital of PLA from June to December 2016 were retrospectively studied. According to whether or not they were taking memantine, the patients were divided into the memantine group and the control group. The data including age, sex, BMI, follow-up time, the neurocognitive function score were collected. The neurocognitive function score was assessed by the Montreal Cognitive Assessment Scale (MoCA). Results There was no significant difference in age, BMI, and follow-up time between the two groups. The MoCA score was(19.19±3.23) in memantine group, (18.47±3.03) in control group, P=0.651;(21.06±2.62)in memantine group,(19.19±2.87) in control group,P=0.038 at 2 weeks;(23.50±2.00) in memantine group,(21.30±2.16) in control group,P=0.002 at 4 weeks;At the last follow-up, memantine group was(24.69±2.09), control group was (23.22±2.08), P=0.031. Conclusion Memantine could effectively improve neurocognitive function in patients with ischemic stroke.

YANG Shichang, HE Jinggui, ZHOU Suyue, LI Xuemei. The retrospective study of the improvement of memantine hydrochloride on neurocognitive function in patients with ischemic stroke[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(5): 457-460. doi: 10.3969/j.issn.1006-0111.2018.05.017
Citation: YANG Shichang, HE Jinggui, ZHOU Suyue, LI Xuemei. The retrospective study of the improvement of memantine hydrochloride on neurocognitive function in patients with ischemic stroke[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(5): 457-460. doi: 10.3969/j.issn.1006-0111.2018.05.017
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