WANG Jian, QIU Yan, LI Keran, ZHU Wenjun, DONG Yafen, LIU Helong. Protective effect of total sesquiterpene lactone from Achillea sibirca on rheumatoid arthritis rats[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 529-532. doi: 10.3969/j.issn.1006-0111.2018.06.011
| Citation:
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WANG Jian, QIU Yan, LI Keran, ZHU Wenjun, DONG Yafen, LIU Helong. Protective effect of total sesquiterpene lactone from Achillea sibirca on rheumatoid arthritis rats[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 529-532. doi: 10.3969/j.issn.1006-0111.2018.06.011
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Protective effect of total sesquiterpene lactone from Achillea sibirca on rheumatoid arthritis rats
- 1.
Department of Pharmacy, People's Hospital of Pudong New Area, Shanghai 201200, China
- 2.
Nanjing No.3 High school, Nanjing 210001, China
- Received Date: 2018-03-30
- Rev Recd Date:
2018-05-11
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Abstract
Objective To investigate the anti-inflammatory effect and mechanism of total sesquiterpene lactone from Achillea sibirca on rheumatoid arthritis rats. Methods An animal model of rheumatoid arthritis was established by the intradermal injection of 0.1 ml Freund's complete adjuvant into the rat right hind limb. Different doses of Achillea sibirca sesquiterpene lactone and tripterygium glycosides were administered for 21 days. The degree of toe swelling,arthritis index and the serum levels of interleukin(IL)-6,IL-1β and tumor necrosis factor α(TNF-α)in all groups were determined. Results Compared with model group,the toe swelling degree in middle and high dose Achillea sibirca sesquiterpene lactone group was significantly inhibited(P<0.05,P<0.01)at day 14, 21 and 28. The arthritis index in the same groups was decreased at day 14, 21 and 28 with statistically significant difference(P<0.05,P<0.01). The total Achillea sibirca sesquiterpene lactone also reduced the serum levels of IL-6,IL-1β and TNF-α(P<0.05,P<0.01). The low, middle and high dose group effectively reduced joint inflammation in a dose-dependent manner. Conclusion Total sesquiterpene lactone from Achillea sibirca exhibited good therapeutic effect on rheumatoid arthritis rats and its mechanism may relate to the down-regulation of IL-6,IL-1β and TNF-α.
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