Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

XU Ling, ZHAO Yan, MAO Ling, ZHANG Xihong. Constipation alleviation and the efficacy improvement of levodopa and benserazide in Parkinson patients with early intestinal flora intervention[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 547-550. doi: 10.3969/j.issn.1006-0111.2018.06.015
Citation: XU Ling, ZHAO Yan, MAO Ling, ZHANG Xihong. Constipation alleviation and the efficacy improvement of levodopa and benserazide in Parkinson patients with early intestinal flora intervention[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 547-550. doi: 10.3969/j.issn.1006-0111.2018.06.015

Constipation alleviation and the efficacy improvement of levodopa and benserazide in Parkinson patients with early intestinal flora intervention

doi: 10.3969/j.issn.1006-0111.2018.06.015
  • Received Date: 2018-05-08
  • Rev Recd Date: 2018-09-19
  • Objective To investigate the effect of early intestinal flora intervention on the symptoms and the efficacy of Levodopa and Benserazide in Parkinson's disease (PD), provide a reference for clinical treatment. Methods 114 patients diagnosed as PD for the first time in our department of neurology from January 2015 to October 2017 were randomly divided into intervention group (n=57) and control group (n=57). Both groups received Levodopa and Benserazide, A triple live bacterial preparation was given to the intervention group only to regulate the intestinal flora. Patient-Assessment of Constipation Quality of Life (PAC-QOL) was used to assess the constipation symptoms and patient's satisfaction. The Unified Parkinson's Disease Rating Scale (UPDRS Ⅲ) was used to evaluate the motor symptoms and psychological status for the patients in both groups before and after treatments. Results 1 The PAC-QOL and BSFS scores in intervention group were improved significantly compared to those before treatment (P<0.05); 2 After the treatments, the UPDRS Ⅲ scores in both groups were improved significantly (P<0.05). The UPDRS Ⅲ score in the intervention group was significantly lower than that in the control group at 4 weeks (P<0.05). 3 Compared with the control group, the HAD-A, HAD-D and PSQI Score were decreased in the intervention group. (P<0.05). Conclusion Early intestinal flora intervention effectively alleviated constipation symptom and improved therapeutic effects of Levodopa and Benserazide preparation. However, the long-term effect remains to be studied.
  • [1] BRAAK H, DE VOS R A I, BOHL J, et al. Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology[J]. Neurosci Lett, 2006, 396(1):67-72.
    [2] 中华医学会神经病学分会运动障碍及帕金森病学组.帕金森病的诊断[J].中华神经科杂志,2006,(6):408-409.
    [3] BERG D, POSTUMA RB, ADLER CH, et al. MDS research criteria for prodromal Parkinson's disease[J]. Mov Disord, 2015, 30(12):1600-1611.
    [4] ZHANG TM, YU SY, GUO P, et al. Nonmotor symptoms in patients with Parkinson disease:A cross-sectional observational study[J]. Medicine (Baltimore), 2016, 95(50):e5400.
    [5] ABBOTT RD, PETROVITCH H, WHITE LR, et al. Frequency of bowel movements and the future risk of Parkinson's disease[J]. Neurology, 2001, 57(3):456-462.
    [6] PETROVITCH H, ABBOTT RD, ROSS GW, et al. Bowel movement frequency in late-life and substantia nigra neuron density at death[J]. Mov Disord, 2009, 24(3):371-376.
    [7] KESHAVARZIAN A, GREEN SJ, ENGEN PA, et al. Colonic bacterial composition in Parkinson's disease[J]. Mov Disord, 2015, 30(10):1351-1360.
    [8] FANG X. Potential role of gut microbiota and tissue barriers in Parkinson's disease and amyotrophic lateral sclerosis[J]. Int J Neurosci, 2016, 126(9):771-776.
    [9] NIELSEN HH, QIU J, FRⅡS S, et al. Treatment for Helicobacter pylori infection and risk of Parkinson's disease in Denmark[J]. Eur J Neurol, 2012, 19(6):864-869.
    [10] DEVOS D, LEBOUVIER T, LARDEUX B, et al. Colonic inflammation in Parkinson's disease[J]. Neurobiol Dis, 2013, 50:42-48.
    [11] FASAN A, BOVE F, GABRIELLI MA, et al. The role of small intestinal bacterial overgrowth in Parkinson's disease[J].Mov Disord,2013,28(9):1241-1249.
    [12] HOLMQVIST S, CHUTNA O, BOUSSET L, et al. Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats[J]. Acta Neuropathol, 2014, 128(6):805-820.
    [13] 王文建,郑跃杰.肠道菌群与中枢神经系统相互作用及相关疾病[J].中国微生态学杂志,2016,28(2):240-245.
    [14] ANIL ANANTHASWAMY.Faecal transplant eases symptoms of Parkinson's disease[J].New Scientist,209:8-9.
    [15] BARICHELLA M, PACCHETTI C, BOLLIRI C, et al. Probiotics and prebiotic fiber for constipation associated with Parkinson disease:an RCT[J]. Neurology, 2016, 87(12):1274-1280.
  • 加载中
  • Cited by

    Periodical cited type(9)

    1. 郝世杰,王锦锋,张心仪,邹建鹏. 八段锦调节肠道菌群对帕金森病抑郁和便秘症状的治疗思路探讨. 中医康复. 2024(06): 20-24 .
    2. 高小童,杨丽静,张鑫杰,马明明. 从脾胃探讨肠道菌群与帕金森病便秘相关性的研究进展. 山东中医药大学学报. 2023(01): 100-105 .
    3. 李亭,郭姗姗,李倩,卢敬钗,刘洋,张丹. 粪菌移植在帕金森病治疗中的作用研究进展. 河北医药. 2021(02): 280-284+289 .
    4. 李永红,郑禄林,黄昶荃. 益生菌对阿尔兹海默病认知功能的影响. 西部医学. 2021(11): 1637-1641 .
    5. 张印,徐显林,杨柠溪,官雪清,彭云慧. 叙事医学健康教育联合益生菌干预对炎症性肠病性关节炎患者睡眠影响. 社区医学杂志. 2020(02): 117-120 .
    6. 王顺,付艺,刘佳惠,白妍. 调神畅情针法对帕金森病伴便秘型大鼠肠道菌群AWCD值、Shannon指数的影响. 中国中医药科技. 2020(04): 568-571 .
    7. 曾奇,刘智斌,王渊,刁秀芸,郭萌. 帕金森病便秘研究进展. 辽宁中医药大学学报. 2020(08): 40-44 .
    8. 王开军. 补肾滋阴润肠方联合乳果糖治疗帕金森病便秘随机平行对照研究. 实用中医内科杂志. 2019(01): 26-29 .
    9. 宋志坚. 帕金森病便秘症状的中西医治疗研究进展. 世界最新医学信息文摘. 2019(66): 86-87 .

    Other cited types(5)

通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(4068) PDF downloads(274) Cited by(14)

Related
Proportional views

Constipation alleviation and the efficacy improvement of levodopa and benserazide in Parkinson patients with early intestinal flora intervention

doi: 10.3969/j.issn.1006-0111.2018.06.015

Abstract: Objective To investigate the effect of early intestinal flora intervention on the symptoms and the efficacy of Levodopa and Benserazide in Parkinson's disease (PD), provide a reference for clinical treatment. Methods 114 patients diagnosed as PD for the first time in our department of neurology from January 2015 to October 2017 were randomly divided into intervention group (n=57) and control group (n=57). Both groups received Levodopa and Benserazide, A triple live bacterial preparation was given to the intervention group only to regulate the intestinal flora. Patient-Assessment of Constipation Quality of Life (PAC-QOL) was used to assess the constipation symptoms and patient's satisfaction. The Unified Parkinson's Disease Rating Scale (UPDRS Ⅲ) was used to evaluate the motor symptoms and psychological status for the patients in both groups before and after treatments. Results 1 The PAC-QOL and BSFS scores in intervention group were improved significantly compared to those before treatment (P<0.05); 2 After the treatments, the UPDRS Ⅲ scores in both groups were improved significantly (P<0.05). The UPDRS Ⅲ score in the intervention group was significantly lower than that in the control group at 4 weeks (P<0.05). 3 Compared with the control group, the HAD-A, HAD-D and PSQI Score were decreased in the intervention group. (P<0.05). Conclusion Early intestinal flora intervention effectively alleviated constipation symptom and improved therapeutic effects of Levodopa and Benserazide preparation. However, the long-term effect remains to be studied.

XU Ling, ZHAO Yan, MAO Ling, ZHANG Xihong. Constipation alleviation and the efficacy improvement of levodopa and benserazide in Parkinson patients with early intestinal flora intervention[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 547-550. doi: 10.3969/j.issn.1006-0111.2018.06.015
Citation: XU Ling, ZHAO Yan, MAO Ling, ZHANG Xihong. Constipation alleviation and the efficacy improvement of levodopa and benserazide in Parkinson patients with early intestinal flora intervention[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 547-550. doi: 10.3969/j.issn.1006-0111.2018.06.015
Reference (15)

Catalog

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return