Constipation alleviation and the efficacy improvement of levodopa and benserazide in Parkinson patients with early intestinal flora intervention

XU Ling; ZHAO Yan; MAO Ling; ZHANG Xihong

doi:10.3969/j.issn.1006-0111.2018.06.015

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Objective To investigate the effect of early intestinal flora intervention on the symptoms and the efficacy of Levodopa and Benserazide in Parkinson's disease (PD), provide a reference for clinical treatment. Methods 114 patients diagnosed as PD for the first time in our department of neurology from January 2015 to October 2017 were randomly divided into intervention group (n=57) and control group (n=57). Both groups received Levodopa and Benserazide, A triple live bacterial preparation was given to the intervention group only to regulate the intestinal flora. Patient-Assessment of Constipation Quality of Life (PAC-QOL) was used to assess the constipation symptoms and patient's satisfaction. The Unified Parkinson's Disease Rating Scale (UPDRS Ⅲ) was used to evaluate the motor symptoms and psychological status for the patients in both groups before and after treatments. Results 1 The PAC-QOL and BSFS scores in intervention group were improved significantly compared to those before treatment (P<0.05); 2 After the treatments, the UPDRS Ⅲ scores in both groups were improved significantly (P<0.05). The UPDRS Ⅲ score in the intervention group was significantly lower than that in the control group at 4 weeks (P<0.05). 3 Compared with the control group, the HAD-A, HAD-D and PSQI Score were decreased in the intervention group. (P<0.05). Conclusion Early intestinal flora intervention effectively alleviated constipation symptom and improved therapeutic effects of Levodopa and Benserazide preparation. However, the long-term effect remains to be studied.

Constipation alleviation and the efficacy improvement of levodopa and benserazide in Parkinson patients with early intestinal flora intervention

Department of Clinical Pharmacy, Liuhe Branch of Nanjing Drum Tower Hospital, Nanjing 211500, China;

Department of Neurology, Liuhe Branch of Nanjing Drum Tower Hospital, Nanjing 211500, China

Received Date: 2018-05-08

Rev Recd Date: 2018-09-19

Key words:

Abstract: Objective To investigate the effect of early intestinal flora intervention on the symptoms and the efficacy of Levodopa and Benserazide in Parkinson's disease (PD), provide a reference for clinical treatment. Methods 114 patients diagnosed as PD for the first time in our department of neurology from January 2015 to October 2017 were randomly divided into intervention group (n=57) and control group (n=57). Both groups received Levodopa and Benserazide, A triple live bacterial preparation was given to the intervention group only to regulate the intestinal flora. Patient-Assessment of Constipation Quality of Life (PAC-QOL) was used to assess the constipation symptoms and patient's satisfaction. The Unified Parkinson's Disease Rating Scale (UPDRS Ⅲ) was used to evaluate the motor symptoms and psychological status for the patients in both groups before and after treatments. Results 1 The PAC-QOL and BSFS scores in intervention group were improved significantly compared to those before treatment (P<0.05); 2 After the treatments, the UPDRS Ⅲ scores in both groups were improved significantly (P<0.05). The UPDRS Ⅲ score in the intervention group was significantly lower than that in the control group at 4 weeks (P<0.05). 3 Compared with the control group, the HAD-A, HAD-D and PSQI Score were decreased in the intervention group. (P<0.05). Conclusion Early intestinal flora intervention effectively alleviated constipation symptom and improved therapeutic effects of Levodopa and Benserazide preparation. However, the long-term effect remains to be studied.

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Reference (15)

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Constipation alleviation and the efficacy improvement of levodopa and benserazide in Parkinson patients with early intestinal flora intervention

doi: 10.3969/j.issn.1006-0111.2018.06.015

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