Optimization of assay method for loganin in Gandi capsules

WEI Xin; XU Renjie; TANG Ying; YAO Huan; XU Ajing; ZHANG Jian

doi:10.3969/j.issn.1006-0111.2018.06.016

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Volume 36 Issue 6

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2018 > 36(6): 551-553

WEI Xin, XU Renjie, TANG Ying, YAO Huan, XU Ajing, ZHANG Jian. Optimization of assay method for loganin in Gandi capsules[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 551-553. doi: 10.3969/j.issn.1006-0111.2018.06.016

Citation:

WEI Xin, XU Renjie, TANG Ying, YAO Huan, XU Ajing, ZHANG Jian. Optimization of assay method for loganin in Gandi capsules[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 551-553. doi: 10.3969/j.issn.1006-0111.2018.06.016

Optimization of assay method for loganin in Gandi capsules

doi: 10.3969/j.issn.1006-0111.2018.06.016

1.
Department of Pharmacy, Xinhua Hospital Affiliated to School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China
2.
Shanghai Fangxin Pharmaceutical Co., Ltd., Shanghai 200120, China

Received Date: 2018-06-01
Rev Recd Date: 2018-09-10

Abstract

Objective To establish a HPLC method for the assay of loganin in Gandi capsules. Methods The Waters Symmtry column C₁₈ (4.6 mm×150 mm, 5 μm) was used with acetonitrile-water (13:87) as mobile phase. The flow rate was 1.0 ml/min and the detection wavelength at 240 nm. Results The calibration curves were linear within the range of 0.030 1-3.01 μg (r=0.999 9) for loganin. The average recovery and relative standard deviation of loganin were 99.62% and 0.86%. Conclusion This method is simple, practicable, accurate and fast. It can be used to assay loganin in Gandi capsules.
- Gandi capsule,
- loganin,
- assay,
- HPLC

References

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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