Advances in pharmacological effects of Traditional Chinese Medicine hops

LIU Jingxue; JIANG Yu; XIE Hehui; HUANG Jin

doi:10.3969/j.issn.1006-0111.2019.01.002

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2019 > 37(1): 5-8,13

LIU Jingxue, JIANG Yu, XIE Hehui, HUANG Jin. Advances in pharmacological effects of Traditional Chinese Medicine hops[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 5-8,13. doi: 10.3969/j.issn.1006-0111.2019.01.002

Citation:

LIU Jingxue, JIANG Yu, XIE Hehui, HUANG Jin. Advances in pharmacological effects of Traditional Chinese Medicine hops[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 5-8,13. doi: 10.3969/j.issn.1006-0111.2019.01.002

Advances in pharmacological effects of Traditional Chinese Medicine hops

doi: 10.3969/j.issn.1006-0111.2019.01.002

1.
Department of Pharmacy, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medcine, Shanghai 200437, China
2.
Department of Pharmacy, Changzheng Hospital Affiliated to Naval Medical University, Shanghai 200003, China
3.
School of Public Health, Shanghai Jiaotong University, Shanghai 200025, China

Received Date: 2018-09-18
Rev Recd Date: 2018-11-21

Abstract

The Hop plant (Humulus lupulus L., Cannabinaceae) is a dioeciou twining perennial.The relevant papers at home and abroad in recent years were reviewed and a summary analysis and induction were conducted to research the progress of hops and provide a basis for further development and application of the medicinal materials.Pharmacological effects of hops were reviewed, which found that hops have a good research prospect and deserve further promotion and development.
- Humulus lupulus,
- pharmacologoical action,
- mechanism of action

References

[1]	中国科学院.中国植物志[M].北京:科学出版社,2013.
[2]	张霞,徐基平,刘海英,等.啤酒花的地理分布与中国的野生啤酒花[J].干旱区资源与环境,2008,22(1):180-183.
[3]	朱丹,牛广财,姜述君,等.酒花的化学成分及药理作用[J].药学专论,2008,17(21):1-2.
[4]	闫晶晶,刘淑敏,郭泽青,等.啤酒花浸膏中α-酸异构化反应影响因素研究[J].食品研究与开发,2016,37(10):28-29.
[5]	施杰.啤酒花中酸类物质的研究进展[J].中国新技术新产品,2011,11(12):5-6.
[6]	张维库,王守宝,李平,等.啤酒花的黄酮类成分[J].中国中药杂志,2013,38(10):1539-1541.
[7]	曹艳,冯作山,王娟,等.啤酒花多酚对去卵巢大鼠脂质代谢的影响[J].食品科技,2015,40(3):221-223.
[8]	林柳悦,蒋益萍,张巧艳,等.啤酒花化学成分和药理活性研究进展[J].中国中药杂志,2017,42(10):1830-1834.
[9]	李宪臻,王伟,堵国成,等.啤酒花抗性机制的研究进展[J].微生物学杂志,2015(5):1-5.
[10]	高智明.啤酒花的抑菌作用及应用拓展[J].食品工业科技,2012,33(23):428-430.
[11]	BOGDANOVA K,RODEROVA M,KOLAR M,et al.Antibiofilm activity of bioactive hop compounds humulone,lupulone and xanthohumol toward susceptible and resistant staphylococci[J].Res Microbiol,2018,169(3):127-134.
[12]	BOGDANOVA K,KOLAR M,LANGOVA K,et al.Inhibitory effect of hop fractions against Gram-positive multi-resistant bacteria[J].Biomed Papers,2018,162:1-7.
[13]	顾晓凤.天然产物黄腐醇研究概况[J].亚太传统医药,2015,11(10):66.
[14]	李玉晶,刘玉梅.啤酒花活性成分与抗氧化活性的相关性研究[J].食品科学,2018,2(28):1-7.
[15]	郭苗,杨小兰.酒花多酚对高脂血症小鼠的降脂与抗氧化作用[J].食品科学,2015,36(3):183-186.
[16]	ANO Y,DOHATA A,TANIGUCHI Y,et al.Iso-α-acids,bitter components of beer,prevent inflammation and cognitive decline induced in a mouse model of Alzheimer's disease[J].J Biol Chem,2017,9(292):3720.
[17]	路欣,杨小兰.啤酒花多酚提取物体内外抗氧化活性研究[J].食品科学,2015,36(1):13-17.
[18]	HUANG X F,WANG J,CHEN X,et al.The prenylflavonoid xanthohumol reduces Alzheimer-like changes and modulates multiple pathogenic molecular pathways in the Neuro2a/App_swe cell model of AD[J].Front Pharmacol,2018,9:199.
[19]	JIANG C H,SUN T L,XIANG D X,et al.Anticancer activity and mechanism of xanthohumol:A prenylated flavonoid from Hops (Humulus lupulus L.)[J].Front Pharmacol,2018,9(530):1-11.
[20]	SELIGER J M,MISURI L,MASER E,et al.The hop-derived compounds xanthohumol,isoxanthohumol and 8-prenylnaringenin are tight-bindinding inhibitors of human aldo-keto reductases 1B1 and 1B10[J].J Enzyme Inhib Med Chem,2018,33(1):607-614.
[21]	SUMIYOSHI M,KIMURA Y.Hop (Humulus lupulus L.) extract inhibits obesity in mice fed a high-fat diet over the long term[J].Br J Nutr,2013,109(1):162-172.
[22]	OBARA K,MIZUTANI M,HITOMI Y,et al.Isohumulones,the bitter component of beer,improve hyperglycemia and decrease body fat in Japanese subjects with prediabetes[J].Clin Nutr,2009,28(3):278-284.
[23]	ZHOU D,WANG C G,LI X,et al.Dietary functional flavonoids as natural hepatoprotective agents against acute liver injury from hop (Humulus lupulus L.)[J].J Func Foods,2018,45:471-479.
[24]	HEGE M,JUNG F,SELLMANN C,et al.An iso-α-acid-rich extract from hops (Humulus lupulus) attenuates acute alcohol-induced liver steatosis in mice[J].Nutrition,2018,45:68-75.
[25]	FERNANDEZ-GARCIA C,RANCAN L,PAREDES S D,et al.Xanthohumol exerts protective effects in liver alterations associated with aging[J].Eur J Nutr,2018,3:1-10.
[26]	崔熠可,陈静华,闫冀,等.啤酒花中的植物雌激素成分8-PN的生物活性及定量分析的研究进展[J].南昌大学学报(医学版),2016,56(5):97-99.
[27]	LUO D,KANG L,MA Y,et al.Effects and mechanisms of 8-prenylnaringenin on osteoblast MC3T3-E1 and osteoclast-like cells RAW264.7[J].Food Sci Nutr,2014,2(4):341-350.
[28]	KEILER A M,HELLE J,BADER M I,et al.A standardized Humulus lupulus (L.) ethanol extract partially prevents ovariectomy-induced bone loss in rat without induction of adverse effects in the uterus[J].Phytomedicine,2017,34:50-58.
[29]	LOU S,ZHENG Y M,LIU S L,et al.Inhibition of hepatitis C virus replication in vitro by xanthohumol,a natural product present in Hops[J].Planta Med,2014,80(2-3):171-176.
[30]	LIU F M,YIN H,DONG J J,et al.Experimental and simulation identification of xanthohumol as an inhibitor and substrate of ABCB1[J].Appl Sci,2018,8(5):681.

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Advances in pharmacological effects of Traditional Chinese Medicine hops

1. Department of Pharmacy, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medcine, Shanghai 200437, China

2. Department of Pharmacy, Changzheng Hospital Affiliated to Naval Medical University, Shanghai 200003, China

3. School of Public Health, Shanghai Jiaotong University, Shanghai 200025, China

Received Date: 2018-09-18

Rev Recd Date: 2018-11-21

Key words:

Abstract: The Hop plant (Humulus lupulus L., Cannabinaceae) is a dioeciou twining perennial.The relevant papers at home and abroad in recent years were reviewed and a summary analysis and induction were conducted to research the progress of hops and provide a basis for further development and application of the medicinal materials.Pharmacological effects of hops were reviewed, which found that hops have a good research prospect and deserve further promotion and development.

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Reference (30)

[1]	中国科学院.中国植物志[M].北京:科学出版社,2013.
[2]	张霞,徐基平,刘海英,等.啤酒花的地理分布与中国的野生啤酒花[J].干旱区资源与环境,2008,22(1):180-183.
[3]	朱丹,牛广财,姜述君,等.酒花的化学成分及药理作用[J].药学专论,2008,17(21):1-2.
[4]	闫晶晶,刘淑敏,郭泽青,等.啤酒花浸膏中α-酸异构化反应影响因素研究[J].食品研究与开发,2016,37(10):28-29.
[5]	施杰.啤酒花中酸类物质的研究进展[J].中国新技术新产品,2011,11(12):5-6.
[6]	张维库,王守宝,李平,等.啤酒花的黄酮类成分[J].中国中药杂志,2013,38(10):1539-1541.
[7]	曹艳,冯作山,王娟,等.啤酒花多酚对去卵巢大鼠脂质代谢的影响[J].食品科技,2015,40(3):221-223.
[8]	林柳悦,蒋益萍,张巧艳,等.啤酒花化学成分和药理活性研究进展[J].中国中药杂志,2017,42(10):1830-1834.
[9]	李宪臻,王伟,堵国成,等.啤酒花抗性机制的研究进展[J].微生物学杂志,2015(5):1-5.
[10]	高智明.啤酒花的抑菌作用及应用拓展[J].食品工业科技,2012,33(23):428-430.
[11]	BOGDANOVA K,RODEROVA M,KOLAR M,et al.Antibiofilm activity of bioactive hop compounds humulone,lupulone and xanthohumol toward susceptible and resistant staphylococci[J].Res Microbiol,2018,169(3):127-134.
[12]	BOGDANOVA K,KOLAR M,LANGOVA K,et al.Inhibitory effect of hop fractions against Gram-positive multi-resistant bacteria[J].Biomed Papers,2018,162:1-7.
[13]	顾晓凤.天然产物黄腐醇研究概况[J].亚太传统医药,2015,11(10):66.
[14]	李玉晶,刘玉梅.啤酒花活性成分与抗氧化活性的相关性研究[J].食品科学,2018,2(28):1-7.
[15]	郭苗,杨小兰.酒花多酚对高脂血症小鼠的降脂与抗氧化作用[J].食品科学,2015,36(3):183-186.
[16]	ANO Y,DOHATA A,TANIGUCHI Y,et al.Iso-α-acids,bitter components of beer,prevent inflammation and cognitive decline induced in a mouse model of Alzheimer's disease[J].J Biol Chem,2017,9(292):3720.
[17]	路欣,杨小兰.啤酒花多酚提取物体内外抗氧化活性研究[J].食品科学,2015,36(1):13-17.
[18]	HUANG X F,WANG J,CHEN X,et al.The prenylflavonoid xanthohumol reduces Alzheimer-like changes and modulates multiple pathogenic molecular pathways in the Neuro2a/App_swe cell model of AD[J].Front Pharmacol,2018,9:199.
[19]	JIANG C H,SUN T L,XIANG D X,et al.Anticancer activity and mechanism of xanthohumol:A prenylated flavonoid from Hops (Humulus lupulus L.)[J].Front Pharmacol,2018,9(530):1-11.
[20]	SELIGER J M,MISURI L,MASER E,et al.The hop-derived compounds xanthohumol,isoxanthohumol and 8-prenylnaringenin are tight-bindinding inhibitors of human aldo-keto reductases 1B1 and 1B10[J].J Enzyme Inhib Med Chem,2018,33(1):607-614.
[21]	SUMIYOSHI M,KIMURA Y.Hop (Humulus lupulus L.) extract inhibits obesity in mice fed a high-fat diet over the long term[J].Br J Nutr,2013,109(1):162-172.
[22]	OBARA K,MIZUTANI M,HITOMI Y,et al.Isohumulones,the bitter component of beer,improve hyperglycemia and decrease body fat in Japanese subjects with prediabetes[J].Clin Nutr,2009,28(3):278-284.
[23]	ZHOU D,WANG C G,LI X,et al.Dietary functional flavonoids as natural hepatoprotective agents against acute liver injury from hop (Humulus lupulus L.)[J].J Func Foods,2018,45:471-479.
[24]	HEGE M,JUNG F,SELLMANN C,et al.An iso-α-acid-rich extract from hops (Humulus lupulus) attenuates acute alcohol-induced liver steatosis in mice[J].Nutrition,2018,45:68-75.
[25]	FERNANDEZ-GARCIA C,RANCAN L,PAREDES S D,et al.Xanthohumol exerts protective effects in liver alterations associated with aging[J].Eur J Nutr,2018,3:1-10.
[26]	崔熠可,陈静华,闫冀,等.啤酒花中的植物雌激素成分8-PN的生物活性及定量分析的研究进展[J].南昌大学学报(医学版),2016,56(5):97-99.
[27]	LUO D,KANG L,MA Y,et al.Effects and mechanisms of 8-prenylnaringenin on osteoblast MC3T3-E1 and osteoclast-like cells RAW264.7[J].Food Sci Nutr,2014,2(4):341-350.
[28]	KEILER A M,HELLE J,BADER M I,et al.A standardized Humulus lupulus (L.) ethanol extract partially prevents ovariectomy-induced bone loss in rat without induction of adverse effects in the uterus[J].Phytomedicine,2017,34:50-58.
[29]	LOU S,ZHENG Y M,LIU S L,et al.Inhibition of hepatitis C virus replication in vitro by xanthohumol,a natural product present in Hops[J].Planta Med,2014,80(2-3):171-176.
[30]	LIU F M,YIN H,DONG J J,et al.Experimental and simulation identification of xanthohumol as an inhibitor and substrate of ABCB1[J].Appl Sci,2018,8(5):681.

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Advances in pharmacological effects of Traditional Chinese Medicine hops

doi: 10.3969/j.issn.1006-0111.2019.01.002

Abstract

References

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通讯作者: 陈斌, bchen63@163.com

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