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LIU Jing, XU Yi, XU Lingling, WU Tiejun, HUANG Jin. Prokineticin 2 mediates peripheral and central sensitization of somatic pain[J]. Journal of Pharmaceutical Practice and Service, 2021, 39(5): 395-398. doi: 10.12206/j.issn.1006-0111.202103006
Citation: ZHU Yuting, Wang Jinhui, LI Maoxing, LI Xiaolin, TAO Wendi, LIU Yantong. Ameliorate effect and mechanism of verbascoside on memory impairment in hypoxic mice[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 23-26. doi: 10.3969/j.issn.1006-0111.2019.01.006

Ameliorate effect and mechanism of verbascoside on memory impairment in hypoxic mice

doi: 10.3969/j.issn.1006-0111.2019.01.006
  • Received Date: 2018-05-14
  • Rev Recd Date: 2018-07-07
  • Objective To investigate the effects and mechanism of verbascoside on hypoxia-induced memory impairment. Methods The eight-arm maze was used to train mice's spatial memory ability. After successful training, mice were randomly divided into five groups:a normoxic control group (distilled water, 0.1 ml/10 g), hypoxic model group (distilled water, 0.1 ml/10 g), the verbascoside low dose group (50 mg/kg), medium dose group(150 mg/kg), and high dose group(300 mg/kg) were administered orally once a day for a total of 7 days. After administration on the fourth day, except for the normoxic control group was placed in the animal room (1 500m), the remaining four groups were placed in a large-scale hypobaric chamber to simulate the hypoxic environment of the plateau (7 500 m, 3 days). Eight-armed maze test (4 000 m) was used and the plasma and brain tissues were dissected out and measured for reactive oxygen species (ROS) in the brain, malondialdehyde (MDA), reduced glutathione (GSH) and total superoxide dismutase (T-SOD) activity in plasma and brain. Results Compared with the normoxic control group, the indexes of the eight-armed maze, ROS and MDA in the brain, MDA in the plasma of the hypoxia model group were significantly increased, and the GSH and T-SOD enzyme activities in the brain and plasma were notably decreased. Compared with the hypoxic model group, the indexes of the eight-armed maze, ROS and MDA in the brain, MDA in the plasma in the various groups of verbascoside were reduced more or less, the GSH and T-SOD enzyme activities in the brain and plasma slightly were increased. Conclusion Verbascoside could ameliorate the hypoxic memory impairment at high altitude, which might be related to the stabilization of the body's antioxidant enzyme system balance and reduce oxidative stress.
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    [3] CARDINALI A, PATI S, MINERVINI F, et al. Verbascoside, isoverbascoside, and their derivativesrecovered from olive mill wastewater as possible food antioxidants[J].J Agric Food Chem,2012, 60(7):1822-1829.
    [4] OYOUROU J N, COMBRINCK S, REGNIER T,et al. Purification, stability and antifungal activity of verbascoside from Lippia javanica and Lantana camara leaf extracts[J]. Ind Crop Prod,2013, 43:820-826.
    [5] SPERANZA L, FRANCESCHELLI S,PESCE M,et al. Antiinflammatory effects in THP-1 cells treated with verbascoside[J]. Phytother Res,2010, 24(9):1398-1404.
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    [7] ESPOSITO E, DAL TOSO R, PRESSI G,et al. Protective effect of verbascoside in activated C6 glioma cells:possible molecular mechanisms[J]. Naunyn Schmiedebergs Arch Pharmacol,2010,381(1):93-105.
    [8] ZHOU B,LI M,CAO X, et al. Phenylethanoid glycosides of Pedicularis muscicola maxim ameliorate high altitude-induced memory impairment[J]. Physiol Behav,2016,157:39-46.
    [9] 李茂星, 周保柱, 刘延彤,等. 藓生马先蒿苯乙醇苷对高原记忆损伤的改善作用及机制研究[J]. 中国药学杂志, 2016, 51(9):703-707.
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    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 20.8 %其他: 20.8 %China: 0.7 %China: 0.7 %Korea Republic of: 0.2 %Korea Republic of: 0.2 %United States: 0.2 %United States: 0.2 %[]: 0.2 %[]: 0.2 %上海: 3.7 %上海: 3.7 %临汾: 0.3 %临汾: 0.3 %北京: 15.9 %北京: 15.9 %南京: 0.2 %南京: 0.2 %大连: 1.0 %大连: 1.0 %天津: 0.2 %天津: 0.2 %广州: 0.7 %广州: 0.7 %张家口: 0.3 %张家口: 0.3 %成都: 0.7 %成都: 0.7 %扬州: 0.3 %扬州: 0.3 %杭州: 1.0 %杭州: 1.0 %武汉: 0.2 %武汉: 0.2 %温州: 0.2 %温州: 0.2 %盐城: 0.2 %盐城: 0.2 %芒廷维尤: 23.4 %芒廷维尤: 23.4 %衡水: 0.2 %衡水: 0.2 %西宁: 25.1 %西宁: 25.1 %西安: 0.2 %西安: 0.2 %赤峰: 0.5 %赤峰: 0.5 %运城: 0.8 %运城: 0.8 %郑州: 0.3 %郑州: 0.3 %重庆: 0.2 %重庆: 0.2 %金华: 0.2 %金华: 0.2 %长治: 0.3 %长治: 0.3 %驻马店: 0.3 %驻马店: 0.3 %黄冈: 1.0 %黄冈: 1.0 %黄冈市麻城: 0.2 %黄冈市麻城: 0.2 %黄石: 0.2 %黄石: 0.2 %龙岩: 0.2 %龙岩: 0.2 %其他ChinaKorea Republic ofUnited States[]上海临汾北京南京大连天津广州张家口成都扬州杭州武汉温州盐城芒廷维尤衡水西宁西安赤峰运城郑州重庆金华长治驻马店黄冈黄冈市麻城黄石龙岩Highcharts.com
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Ameliorate effect and mechanism of verbascoside on memory impairment in hypoxic mice

doi: 10.3969/j.issn.1006-0111.2019.01.006

Abstract: Objective To investigate the effects and mechanism of verbascoside on hypoxia-induced memory impairment. Methods The eight-arm maze was used to train mice's spatial memory ability. After successful training, mice were randomly divided into five groups:a normoxic control group (distilled water, 0.1 ml/10 g), hypoxic model group (distilled water, 0.1 ml/10 g), the verbascoside low dose group (50 mg/kg), medium dose group(150 mg/kg), and high dose group(300 mg/kg) were administered orally once a day for a total of 7 days. After administration on the fourth day, except for the normoxic control group was placed in the animal room (1 500m), the remaining four groups were placed in a large-scale hypobaric chamber to simulate the hypoxic environment of the plateau (7 500 m, 3 days). Eight-armed maze test (4 000 m) was used and the plasma and brain tissues were dissected out and measured for reactive oxygen species (ROS) in the brain, malondialdehyde (MDA), reduced glutathione (GSH) and total superoxide dismutase (T-SOD) activity in plasma and brain. Results Compared with the normoxic control group, the indexes of the eight-armed maze, ROS and MDA in the brain, MDA in the plasma of the hypoxia model group were significantly increased, and the GSH and T-SOD enzyme activities in the brain and plasma were notably decreased. Compared with the hypoxic model group, the indexes of the eight-armed maze, ROS and MDA in the brain, MDA in the plasma in the various groups of verbascoside were reduced more or less, the GSH and T-SOD enzyme activities in the brain and plasma slightly were increased. Conclusion Verbascoside could ameliorate the hypoxic memory impairment at high altitude, which might be related to the stabilization of the body's antioxidant enzyme system balance and reduce oxidative stress.

LIU Jing, XU Yi, XU Lingling, WU Tiejun, HUANG Jin. Prokineticin 2 mediates peripheral and central sensitization of somatic pain[J]. Journal of Pharmaceutical Practice and Service, 2021, 39(5): 395-398. doi: 10.12206/j.issn.1006-0111.202103006
Citation: ZHU Yuting, Wang Jinhui, LI Maoxing, LI Xiaolin, TAO Wendi, LIU Yantong. Ameliorate effect and mechanism of verbascoside on memory impairment in hypoxic mice[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 23-26. doi: 10.3969/j.issn.1006-0111.2019.01.006
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