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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2019  >  37(4): 304-308

MAN Huan, ZHANG Feng, HUANG Doudou, XIONG Xiaojuan, ZHAN Qin, LIAO Lina, LI Tiejun, CHEN Wansheng. Protective effect of Shengxian decoction and each single herb component against adriamycin-induced cardiomyocyte injury[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 304-308. doi: 10.3969/j.issn.1006-0111.2019.04.004
Citation: MAN Huan, ZHANG Feng, HUANG Doudou, XIONG Xiaojuan, ZHAN Qin, LIAO Lina, LI Tiejun, CHEN Wansheng. Protective effect of Shengxian decoction and each single herb component against adriamycin-induced cardiomyocyte injury[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 304-308. doi: 10.3969/j.issn.1006-0111.2019.04.004
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Protective effect of Shengxian decoction and each single herb component against adriamycin-induced cardiomyocyte injury

doi: 10.3969/j.issn.1006-0111.2019.04.004
  • 1.

    Department of Medicine, Changzheng Hospital, Naval Medical University, Shanghai 200003, China;College of Chemical and Biological Engineering, Yichun University, Yichun 336000, China

  • 2.

    Department of Medicine, Changzheng Hospital, Naval Medical University, Shanghai 200003, China

  • 3.

    College of Chemical and Biological Engineering, Yichun University, Yichun 336000, China

  • 4.

    Department of Pharmacology, College of Pharmacy, Naval Medical University, Shanghai 200433, China

  • Received Date: 2018-09-05
  • Rev Recd Date: 2019-02-26
  • Objective To study the protective effect of Shengxian decoction (SXT) and its each single herb component against doxorubicin induced cardiomyocyte injury. Methods Myocardial cells isolated from the neonatal rats with hypoxia/reoxygenation injury of cardiomyocytes were divided into eight groups,control group (Con group),doxorubicin-induced injury group (M group),and treatment groups with Shengxian decoction and its each single herb decoction (SXT,A-E groups) following doxorubicin-induced injury.The indicators tested included cell viability,cell ROS,Ca2+ and LDH levels. Results Compared with the control group,doxorubicin induced obvious myocardial injury in model group.Compared with the model group,all tested drug groups increased the cell viability,reduced the levels of cell Ca2+ and LDH.Besides,SXT and the single herb decoction reduced the concentration of ROS except the decoction of Platycodon grandiflorum and Cimicifuage Rhizoma.The experimental results suggested that the application of SXT in the early episode could reduce the cardiac toxicity of adriamycin to a certain extent. Conclusion SXT and its each single herb decoction showed protective effect against doxorubicin-induced cardiomyocyte injury.
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Protective effect of Shengxian decoction and each single herb component against adriamycin-induced cardiomyocyte injury

doi: 10.3969/j.issn.1006-0111.2019.04.004
  • 1. Department of Medicine, Changzheng Hospital, Naval Medical University, Shanghai 200003, China;College of Chemical and Biological Engineering, Yichun University, Yichun 336000, China
  • 2. Department of Medicine, Changzheng Hospital, Naval Medical University, Shanghai 200003, China
  • 3. College of Chemical and Biological Engineering, Yichun University, Yichun 336000, China
  • 4. Department of Pharmacology, College of Pharmacy, Naval Medical University, Shanghai 200433, China
  • Received Date: 2018-09-05
  • Rev Recd Date: 2019-02-26

Abstract: Objective To study the protective effect of Shengxian decoction (SXT) and its each single herb component against doxorubicin induced cardiomyocyte injury. Methods Myocardial cells isolated from the neonatal rats with hypoxia/reoxygenation injury of cardiomyocytes were divided into eight groups,control group (Con group),doxorubicin-induced injury group (M group),and treatment groups with Shengxian decoction and its each single herb decoction (SXT,A-E groups) following doxorubicin-induced injury.The indicators tested included cell viability,cell ROS,Ca2+ and LDH levels. Results Compared with the control group,doxorubicin induced obvious myocardial injury in model group.Compared with the model group,all tested drug groups increased the cell viability,reduced the levels of cell Ca2+ and LDH.Besides,SXT and the single herb decoction reduced the concentration of ROS except the decoction of Platycodon grandiflorum and Cimicifuage Rhizoma.The experimental results suggested that the application of SXT in the early episode could reduce the cardiac toxicity of adriamycin to a certain extent. Conclusion SXT and its each single herb decoction showed protective effect against doxorubicin-induced cardiomyocyte injury.

MAN Huan, ZHANG Feng, HUANG Doudou, XIONG Xiaojuan, ZHAN Qin, LIAO Lina, LI Tiejun, CHEN Wansheng. Protective effect of Shengxian decoction and each single herb component against adriamycin-induced cardiomyocyte injury[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 304-308. doi: 10.3969/j.issn.1006-0111.2019.04.004
Citation: MAN Huan, ZHANG Feng, HUANG Doudou, XIONG Xiaojuan, ZHAN Qin, LIAO Lina, LI Tiejun, CHEN Wansheng. Protective effect of Shengxian decoction and each single herb component against adriamycin-induced cardiomyocyte injury[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 304-308. doi: 10.3969/j.issn.1006-0111.2019.04.004
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