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Volume 37 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2019  >  37(4): 375-379

RUAN Jun, YIN Heng, KOU Guoxian, LIU Mingxin, YANG Ruixi. A Meta-analysis on magnesium isoglycyrrhizinate in treatment of antituberculosis drug-induced liver injury[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 375-379. doi: 10.3969/j.issn.1006-0111.2019.04.018
Citation: RUAN Jun, YIN Heng, KOU Guoxian, LIU Mingxin, YANG Ruixi. A Meta-analysis on magnesium isoglycyrrhizinate in treatment of antituberculosis drug-induced liver injury[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 375-379. doi: 10.3969/j.issn.1006-0111.2019.04.018
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A Meta-analysis on magnesium isoglycyrrhizinate in treatment of antituberculosis drug-induced liver injury

doi: 10.3969/j.issn.1006-0111.2019.04.018
  • 1.

    Sichuan Mianyang Central Hospital, Department of infectious, Mianyang 621000, China

  • 2.

    Sichuan Mianyang Central Hospital, Department of nephrology, Mianyang 621000, China

  • Received Date: 2019-01-30
  • Rev Recd Date: 2019-05-14
  • Objective To evaluate the therapeutic effects of magnesium isoglycyrrhizinate in patients with antituberculosis drug-induced liver injury. Methods The literatures related to randomized controlled trials (RCT) of magnesium isoglycyrrhizinate treatment in patients with antituberculosis drug-induced liver injury were retrieved from CNKI,VIP,WanFang database,PubMed,EMbase and Cochrane Library.The collected literatures were published before April 2019.Based on the inclusive and exclusive criteria,the literatures were screened,and data were extracted by two researchers independently.Meanwhile the quality of the included studies was assessed.Meta-analysis was conducted by RevMan 5.2 software. Results 823 patients with antituberculosis drug-induced liver injury in ten RCT were enrolled.The meta-analysis demonstrated,a) compared with control group,the early-stage administration of magnesium isoglycyrrhizinate can effectively treat liver injury caused by antituberculosis drugs with statistical significance,and b) magnesium isoglycyrrhizinate can significantly reduce the alanine aminotransferase level and improve the total bilirubin level during the treatment. Conclusion Magnesium isoglycyrrhizinate administration is an effective treatment for liver injury caused by antituberculosis drugs although more high-quality researches are needed for further verification.
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    [10] 邓敏,宣华,余晓,等.异甘草酸镁联合谷胱甘肽治疗抗结核药物所致中度以上肝损害疗效观察[J].浙江实用医学,2013,18(3):177-178.
    [11] 郭新枝,陈裕,程俊伟,等.异甘草酸镁注射液治疗抗结核药物所致急性肝损伤的临床研究[J].微生物与感染,2013,8(3):157-162.
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    [13] 陈永芳,程俊伟,陈裕,等.异甘草酸镁注射液治疗抗结核药物所致急性肝损伤的疗效分析[J].北京医学,2014,36(3):223-225.
    [14] 熊延军,李东方,孙红,等.异甘草酸镁治疗抗结核药物性肝损害的效果分析[J].中国当代医药,2014,21(5):68-69,72.
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A Meta-analysis on magnesium isoglycyrrhizinate in treatment of antituberculosis drug-induced liver injury

doi: 10.3969/j.issn.1006-0111.2019.04.018
  • 1. Sichuan Mianyang Central Hospital, Department of infectious, Mianyang 621000, China
  • 2. Sichuan Mianyang Central Hospital, Department of nephrology, Mianyang 621000, China
  • Received Date: 2019-01-30
  • Rev Recd Date: 2019-05-14

Abstract: Objective To evaluate the therapeutic effects of magnesium isoglycyrrhizinate in patients with antituberculosis drug-induced liver injury. Methods The literatures related to randomized controlled trials (RCT) of magnesium isoglycyrrhizinate treatment in patients with antituberculosis drug-induced liver injury were retrieved from CNKI,VIP,WanFang database,PubMed,EMbase and Cochrane Library.The collected literatures were published before April 2019.Based on the inclusive and exclusive criteria,the literatures were screened,and data were extracted by two researchers independently.Meanwhile the quality of the included studies was assessed.Meta-analysis was conducted by RevMan 5.2 software. Results 823 patients with antituberculosis drug-induced liver injury in ten RCT were enrolled.The meta-analysis demonstrated,a) compared with control group,the early-stage administration of magnesium isoglycyrrhizinate can effectively treat liver injury caused by antituberculosis drugs with statistical significance,and b) magnesium isoglycyrrhizinate can significantly reduce the alanine aminotransferase level and improve the total bilirubin level during the treatment. Conclusion Magnesium isoglycyrrhizinate administration is an effective treatment for liver injury caused by antituberculosis drugs although more high-quality researches are needed for further verification.

RUAN Jun, YIN Heng, KOU Guoxian, LIU Mingxin, YANG Ruixi. A Meta-analysis on magnesium isoglycyrrhizinate in treatment of antituberculosis drug-induced liver injury[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 375-379. doi: 10.3969/j.issn.1006-0111.2019.04.018
Citation: RUAN Jun, YIN Heng, KOU Guoxian, LIU Mingxin, YANG Ruixi. A Meta-analysis on magnesium isoglycyrrhizinate in treatment of antituberculosis drug-induced liver injury[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 375-379. doi: 10.3969/j.issn.1006-0111.2019.04.018
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