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Volume 13 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 1995  >  (3): 136-139

Li Sa, Li Wanhai, Tao Xuebin, Chen Dongming, Chen Jie. Protective effects of sodium diethyldithiocarbamate on ischemia-reperfusion-induced brain injury in Mongolian gerbil[J]. Journal of Pharmaceutical Practice and Service, 1995, (3): 136-139.
Citation: Li Sa, Li Wanhai, Tao Xuebin, Chen Dongming, Chen Jie. Protective effects of sodium diethyldithiocarbamate on ischemia-reperfusion-induced brain injury in Mongolian gerbil[J]. Journal of Pharmaceutical Practice and Service, 1995, (3): 136-139.
shu

Protective effects of sodium diethyldithiocarbamate on ischemia-reperfusion-induced brain injury in Mongolian gerbil

  • 1.

    Department of Natural and Synthetic Drug Research, College of Pharmacy, Second Militray Medical University Shanghai 200433

  • 2.

    Department of Natural and Synthetic Drug Research, College of Pharmacy, Second Militray Medical University Shanghai 200433

  • Brain injury in Mongolian gerbil(Meriones unguiculatus) was induced by occluding bilateral common carotid arteries followed by reperfusion. Levels of ATP, ADP and HX in gerbil brain measured by HPLC method were decreased and increased significantly respectively after 60 min cerebral ischemia. The level of oxygen free radicals(OFR) measured by electron spin resonance(ESR)were increased significantly only at 5-min reperfusion. DTC, iv 50 mg·kg-115 min before occlusion, increased level of ATP and ADP in brain,reduced edema of neuron and tissue of brain and decreased the level of OFR in 5-min reperfusion group and the mortality of gerbil to 50% as dexame thasone did in the reperfusion group. The results suggested that DTC had protective effects on ischemia-reperfusion induced gerbil brain injury. The OFR in gerbil brain may be formated mainly by the route of xanthine oxidase.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Protective effects of sodium diethyldithiocarbamate on ischemia-reperfusion-induced brain injury in Mongolian gerbil

  • 1. Department of Natural and Synthetic Drug Research, College of Pharmacy, Second Militray Medical University Shanghai 200433
  • 2. Department of Natural and Synthetic Drug Research, College of Pharmacy, Second Militray Medical University Shanghai 200433

Abstract: Brain injury in Mongolian gerbil(Meriones unguiculatus) was induced by occluding bilateral common carotid arteries followed by reperfusion. Levels of ATP, ADP and HX in gerbil brain measured by HPLC method were decreased and increased significantly respectively after 60 min cerebral ischemia. The level of oxygen free radicals(OFR) measured by electron spin resonance(ESR)were increased significantly only at 5-min reperfusion. DTC, iv 50 mg·kg-115 min before occlusion, increased level of ATP and ADP in brain,reduced edema of neuron and tissue of brain and decreased the level of OFR in 5-min reperfusion group and the mortality of gerbil to 50% as dexame thasone did in the reperfusion group. The results suggested that DTC had protective effects on ischemia-reperfusion induced gerbil brain injury. The OFR in gerbil brain may be formated mainly by the route of xanthine oxidase.

Li Sa, Li Wanhai, Tao Xuebin, Chen Dongming, Chen Jie. Protective effects of sodium diethyldithiocarbamate on ischemia-reperfusion-induced brain injury in Mongolian gerbil[J]. Journal of Pharmaceutical Practice and Service, 1995, (3): 136-139.
Citation: Li Sa, Li Wanhai, Tao Xuebin, Chen Dongming, Chen Jie. Protective effects of sodium diethyldithiocarbamate on ischemia-reperfusion-induced brain injury in Mongolian gerbil[J]. Journal of Pharmaceutical Practice and Service, 1995, (3): 136-139.
shu

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