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1995 Vol. 13, No. 3

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1995, (3): 131-134.
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1995, (3): 135-135.
Abstract(1927) PDF (937KB)(300)
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1995, (3): 135-135.
Abstract(1880) PDF (937KB)(589)
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Protective effects of sodium diethyldithiocarbamate on ischemia-reperfusion-induced brain injury in Mongolian gerbil
Li Sa, Li Wanhai, Tao Xuebin, Chen Dongming, Chen Jie
1995, (3): 136-139.
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Brain injury in Mongolian gerbil(Meriones unguiculatus) was induced by occluding bilateral common carotid arteries followed by reperfusion. Levels of ATP, ADP and HX in gerbil brain measured by HPLC method were decreased and increased significantly respectively after 60 min cerebral ischemia. The level of oxygen free radicals(OFR) measured by electron spin resonance(ESR)were increased significantly only at 5-min reperfusion. DTC, iv 50 mg·kg-115 min before occlusion, increased level of ATP and ADP in brain,reduced edema of neuron and tissue of brain and decreased the level of OFR in 5-min reperfusion group and the mortality of gerbil to 50% as dexame thasone did in the reperfusion group. The results suggested that DTC had protective effects on ischemia-reperfusion induced gerbil brain injury. The OFR in gerbil brain may be formated mainly by the route of xanthine oxidase.
1995, (3): 139-141.
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1995, (3): 141-144,186.
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Pharmacology and clinical effect of the tosufloxacin
Li Mei
1995, (3): 145-149.
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This article reports activities of the Tosufloxacin in vitro and in vivo, toxicity, pharmacokinetics, clinical effects. Tosufloxacin has a broad spectrum against Gram-postive and-negative bacteria. It has potent antibacterial activities against Gram bacteria was Superior to Ciprofloxacin and Ofloxacin. It was well absorbed after oral administration. Clinic had excellent effect with various infections of patients and side was low.
1995, (3): 149-152.
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1995, (3): 152-154.
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1995, (3): 154-154.
Abstract(1928) PDF (920KB)(433)
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1995, (3): 155-157.
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1995, (3): 157-158.
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Study on stability of Suanzaoren pellet
Zhao Xinghong, Feng Lei, Xue Dunyuan
1995, (3): 159-160.
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The stability of SuanZaoRen pellet was studied with the method of constant temperature acceleration test according to the principle of chemial dynamics. It's content was determined and t0.925 was predictively determined to be 2.96a.
Studies on the dissolution and bioavailability of the rectal capsule of acetaminophene
Sheng Jie, Zheng Zhian, Zhou Jiaxiu, Jiang Hongying, Yan Yan, Ge Qi
1995, (3): 161-164.
Abstract:
The rectal capsule of acetaminophene was prepared, it can be formed several sizes by children's weight so as to administrate in personal. Tmax, Cmax and AUC of the capsule and the suppository commercial were 1.87, 1.67h; 54.86, 46.69(μg/ml); 198.94, 188.94 (μg·h/ml) in rabbits respectively, the results showed that the suppository of acetaminophene can be substitued by the rectal capsule, it was a new dosage form in rectal administration, it's dissolution in vitro was determined by the method of rotating-cylinder with millipore memberane(RCMM) established by ourself. There are a significant correlation between the cumulative dissolution rates in vitro and the absorption rates in vivo, and the both meets zero-order kinetics, the results showed that RCMM could simulated the dissolution of rectal capsule in rectal, it provided a new method of determing dissolution of soluble suppositories, RCMM can simulated the conditions of poor liquid, pH≈7, temperature higher than body temperature but cann't simulated the larger absorption area and the pressure of rectal acting on preparations in rectal, it has several advantages such as simple operating, fixed diffusion area, regulating millipore memberane and non-ignoring the differances of preparations.
Studies on the preparation and stability test of ocustilla ftibamzoni
Wu Huizhen
1995, (3): 164-166.
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This paper reported a improved recipe and prescription technological process of Ftibamzonum Eye Drops(Ocustilla Ftibamzoni). The examinational results of 8 lots of products showed that the quality is stable and it stores well in 2 years at room temperature.
Compatible stability of injection dexamethasone sodium phosphate and injection vitamin B6
Sun Chengchun, Chen Dongmei, Wang Jingxiang
1995, (3): 166-167,160.
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Compatible stability of injection Dexamethasone Sodium Phosphate and injection Vitamin B6 in 5% glucose injection were observed. The results showed that there were no significant changes in outward, pH and Rf in 6h after they had been mixed. Ultraviolet spectrophotometry was used to detect the content of Dexamethasone Sodium Phosphate. The results showed there were no significant changes. It has proved that the two drugs were compatible.
1995, (3): 168-170.
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1995, (3): 170-170.
Abstract(2669) PDF (819KB)(595)
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1995, (3): 171-172.
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1995, (3): 172-173.
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Simultaneous determination of two components in compound furacilin nasal drops by the convolution curve method
Song Hongjie, Wu Yutian, Jin Wenxiang, Wu Xiaofang
1995, (3): 174-176.
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The paper reported the determination of furacilin(Ⅰ) and ephedrine hydrochloride (Ⅱ)in compound furacilin nasal drops by the convolution curve methods without prior separation. The average recovery and the relative standard deviation were 99.87%,0.65%for(Ⅰ) and 100.04%,0.52% for(Ⅱ).
1995, (3): 177-178.
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Ultraviolet spectrophotometry in the determination of content of paeonol-β-cyclodextrin encapsuled
Gao Jie, Zhang Chun, Lin Houwen
1995, (3): 179-181.
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A ultraviolet spectrophotometric rnethod for quantitative determination of paeonol-β-cyclodextrin encapsuled was established in the paper. Petroleum benzine was used as the solvent. The detective wavelength was 316nm. The method was linear within the concentration range of 4~20μg/ml,r=0.9999. Absorbtivity (E1cm1%) was 396.
UV-Spectrophotometric determination of paracetamol in its effervescent tablet
Wang Jin, Yang Libin, Han Jiarong, Li Zhongyi, Yu Zhanrong
1995, (3): 181-183.
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A UV-Spectrophotometric method was successfully used at 257±1nm for determination of paracetamol in its effervescent tablet. The linear relationship between concentration and absorbance was well. The correlation coefficient was 0.99998, the average recovery 99.94%, and the coefficient of variation was 0.20%. The results show that method is simple, rapid and accurate.
The studies on the organic acid constituents from Liaoxi propolis
Chi Jiaping, Chen Haisheng, Xue Bingwen, Weng Xiaoxing
1995, (3): 184-186.
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Five compounds(Ⅰ-Ⅴ) were isolated from Liaoxi propolis. Their chemical structures were established as multi-sulfur S8(Ⅰ),3,4-dimethoxylcinnamic acid(Ⅱ), isoferulic acid(Ⅲ), Caffeic acid(Ⅳ), and benzoic acid(Ⅴ) by spectra. Ⅰ and Ⅴ were found from the propolis for the first time.
1995, (3): 187-188.
Abstract(1733) PDF (779KB)(417)
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1995, (3): 188-189.
Abstract(2066) PDF (810KB)(754)
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1995, (3): 190-190.
Abstract(1904) PDF (164KB)(450)
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1995, (3): 190-191.
Abstract(2116) PDF (810KB)(1248)
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1995, (3): 191-192.
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1995, (3): 192-192.
Abstract(1620) PDF (690KB)(466)
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