Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

Sheng Jie, Zheng Zhian, Zhou Jiaxiu, Jiang Hongying, Yan Yan, Ge Qi. Studies on the dissolution and bioavailability of the rectal capsule of acetaminophene[J]. Journal of Pharmaceutical Practice and Service, 1995, (3): 161-164.
Citation: Sheng Jie, Zheng Zhian, Zhou Jiaxiu, Jiang Hongying, Yan Yan, Ge Qi. Studies on the dissolution and bioavailability of the rectal capsule of acetaminophene[J]. Journal of Pharmaceutical Practice and Service, 1995, (3): 161-164.

Studies on the dissolution and bioavailability of the rectal capsule of acetaminophene

  • The rectal capsule of acetaminophene was prepared, it can be formed several sizes by children's weight so as to administrate in personal. Tmax, Cmax and AUC of the capsule and the suppository commercial were 1.87, 1.67h; 54.86, 46.69(μg/ml); 198.94, 188.94 (μg·h/ml) in rabbits respectively, the results showed that the suppository of acetaminophene can be substitued by the rectal capsule, it was a new dosage form in rectal administration, it's dissolution in vitro was determined by the method of rotating-cylinder with millipore memberane(RCMM) established by ourself. There are a significant correlation between the cumulative dissolution rates in vitro and the absorption rates in vivo, and the both meets zero-order kinetics, the results showed that RCMM could simulated the dissolution of rectal capsule in rectal, it provided a new method of determing dissolution of soluble suppositories, RCMM can simulated the conditions of poor liquid, pH≈7, temperature higher than body temperature but cann't simulated the larger absorption area and the pressure of rectal acting on preparations in rectal, it has several advantages such as simple operating, fixed diffusion area, regulating millipore memberane and non-ignoring the differances of preparations.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(2707) PDF downloads(514) Cited by()

Related
Proportional views

Studies on the dissolution and bioavailability of the rectal capsule of acetaminophene

Abstract: The rectal capsule of acetaminophene was prepared, it can be formed several sizes by children's weight so as to administrate in personal. Tmax, Cmax and AUC of the capsule and the suppository commercial were 1.87, 1.67h; 54.86, 46.69(μg/ml); 198.94, 188.94 (μg·h/ml) in rabbits respectively, the results showed that the suppository of acetaminophene can be substitued by the rectal capsule, it was a new dosage form in rectal administration, it's dissolution in vitro was determined by the method of rotating-cylinder with millipore memberane(RCMM) established by ourself. There are a significant correlation between the cumulative dissolution rates in vitro and the absorption rates in vivo, and the both meets zero-order kinetics, the results showed that RCMM could simulated the dissolution of rectal capsule in rectal, it provided a new method of determing dissolution of soluble suppositories, RCMM can simulated the conditions of poor liquid, pH≈7, temperature higher than body temperature but cann't simulated the larger absorption area and the pressure of rectal acting on preparations in rectal, it has several advantages such as simple operating, fixed diffusion area, regulating millipore memberane and non-ignoring the differances of preparations.

Sheng Jie, Zheng Zhian, Zhou Jiaxiu, Jiang Hongying, Yan Yan, Ge Qi. Studies on the dissolution and bioavailability of the rectal capsule of acetaminophene[J]. Journal of Pharmaceutical Practice and Service, 1995, (3): 161-164.
Citation: Sheng Jie, Zheng Zhian, Zhou Jiaxiu, Jiang Hongying, Yan Yan, Ge Qi. Studies on the dissolution and bioavailability of the rectal capsule of acetaminophene[J]. Journal of Pharmaceutical Practice and Service, 1995, (3): 161-164.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return