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Zhang Qinglin, Wang Aiping. Reproductive toxicity studies of paclitaxel to rats prior to and in the early stages of pregrancy[J]. Journal of Pharmaceutical Practice and Service, 1996, (4): 199-201.
Citation: Zhang Qinglin, Wang Aiping. Reproductive toxicity studies of paclitaxel to rats prior to and in the early stages of pregrancy[J]. Journal of Pharmaceutical Practice and Service, 1996, (4): 199-201.

Reproductive toxicity studies of paclitaxel to rats prior to and in the early stages of pregrancy

  • Paclitaxel,an antineoplastic agent,was administered intravenously to rats daily at dose levels of 0(saline and vehicle),0.1,0.3 and 1.0 mg/kg for 63 days prior to mating and during the wating period in males,and for 14 days prior to mating and during the mating period as well as day 0 to 7 of gestation in females. The results manifest that 1.0mg/kg Paclitaxel caused suppression of the body weight gains accompanied by the decreased food consumption in either male or female rats. Adrenal and ovarian weight were decreased in 1.0mg/kg dams at term. The fertility indices in both sexes of 1.0mg/kg were lower than the saline-treated group. However,the copulation indices in both sexes in 1.0 mg/kg rats were comparable to those of the saline-treated group.Decreases in the number of corpora lutea, implantations and live futuses or increases in the number fo empty implantation sits and total embryofetal deaths were observed in 1.0mg/kg dams. However, the fetal weights, crown-rump distances and tail lengths in live fetuses were not affected by paclitaxel treatment.
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Reproductive toxicity studies of paclitaxel to rats prior to and in the early stages of pregrancy

Abstract: Paclitaxel,an antineoplastic agent,was administered intravenously to rats daily at dose levels of 0(saline and vehicle),0.1,0.3 and 1.0 mg/kg for 63 days prior to mating and during the wating period in males,and for 14 days prior to mating and during the mating period as well as day 0 to 7 of gestation in females. The results manifest that 1.0mg/kg Paclitaxel caused suppression of the body weight gains accompanied by the decreased food consumption in either male or female rats. Adrenal and ovarian weight were decreased in 1.0mg/kg dams at term. The fertility indices in both sexes of 1.0mg/kg were lower than the saline-treated group. However,the copulation indices in both sexes in 1.0 mg/kg rats were comparable to those of the saline-treated group.Decreases in the number of corpora lutea, implantations and live futuses or increases in the number fo empty implantation sits and total embryofetal deaths were observed in 1.0mg/kg dams. However, the fetal weights, crown-rump distances and tail lengths in live fetuses were not affected by paclitaxel treatment.

Zhang Qinglin, Wang Aiping. Reproductive toxicity studies of paclitaxel to rats prior to and in the early stages of pregrancy[J]. Journal of Pharmaceutical Practice and Service, 1996, (4): 199-201.
Citation: Zhang Qinglin, Wang Aiping. Reproductive toxicity studies of paclitaxel to rats prior to and in the early stages of pregrancy[J]. Journal of Pharmaceutical Practice and Service, 1996, (4): 199-201.

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